Radiotherapy alone in carcinoma of the intact uterine cervix according to G. H. Fletcher guidelines: A french cooperative study of 1383 cases

Continuous or Split-Course Combined External and Intracavitary Radiotherapy of Locally Advanced Carcinoma of the Uterine Cervix

“…This is indicated by the lack of improvement in late moderate rectosigmoid and urinary bladder morbidity after the SCRT strategy. The estimates of local tumour control were in agreement with those reported in the literature (23,26,(29)(30)(31). However, the 5-year actuarial estimates of crude survival and no evidence of disease were only comparable with those reported in a few studies (31,32), whereas several other authors found higher rates (19,23,26,29,30,33).…”

Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix

“…Most investigators correlated tumor size and stage with the 5-year survival (5)(6)(7)(8)(9)(10)(11)(12). Bulky tumor was defined as Ͼ6 cm (32,55).…”

“…The combination of external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT) is considered the standard of care, except in younger patients with early-stage disease. Many large series have reported 5-year disease-free survival (DFS) rates of 80 -90% for Stage I, 55-70% for Stage II, 30 -50% for Stage III, and 10 -15% for Stage IV disease (5)(6)(7)(8)(9)(10)(11)(12). Conventional ICBT with tandem and ovoids or ovoids alone may not deliver an adequate dose in cases of extensive and bulky tumors, obliterated fornices, lower vaginal involvement, and carcinoma of the cervical stump (13,14).…”

Radiotherapy Combined with Transcatheter Arterial Infusion Chemotherapy for Locally Advanced Cervical Cancer

“…The cure rate for locally advanced cervical cancer treated with irradiation alone, however, is not satisfactory. The 5-year survival rates for stages III and IVA treated with RT alone were reported as 33% -53% and 0%-29%, respectively (3)(4)(5)(6). Various kinds of new modalities including irradiation combined with neoadjuvant chemotherapy (7), hyperthermia (8), misonidazole (9), and so on, have therefore been undertaken for locally advanced cervical cancer, but the results thus far have not been encouraging.…”