Raised Antibody Titres to Measles and Rubella Viruses in Chronic Active Hepatitis

Viral antibodies and autoantibodies in chronic liver disease

“…In a previous communication (Triger, Kurtz, MacCallum, and Wright, 1972) we have noted h,g'ly significant increases in high titre antibodies to measles and rubella viruses in patients with chronic active hepatitis. This report extends the earlier observations on antibodies to viral antigens and also examines the correlation with immunofluorescent autoantibodies in patients with chronic liver disease.…”

Studies of an outbreak of acute hepatitis A: II. Antibody changes to cytomegalovirus and herpesvirus

“…If temporary liver damage by acute hepatitis A infection stimulates Kupffer cells and liver macrophages, and this causes antibody rises to childhood viruses, CMV would likely be involved. Although the antibody titers to two other primarily childhood viruses, measles and rubella, were reported to be increased in chronic active hepatitis (Triger, Kurtz, MacCallum, and Wright, 1972) no examination for CMV antibody was made in that study; nor are we aware of acute and convalescent sera from acute hepatitis A cases being examined for antibody changes to such a variety of viral antigens as in the present study.…”

“…It appears, therefore, that the stimulation of the already existing CMV and herpesvirus antibody titers in the affected children occurred a few weeks before the hepatitis symptoms appeared and that these levels were either at their peak or already beginning to fall when our acute samples were drawn. Such an occurrence could account for the titer decreases seen in t h s outbreak of acute hepatitis A in confrast to the titer increases reported in chronic hepatitis (Triger, Kurtz, MacCallum, and Wright, 1972). diagnosed in the last few years and often involves the liver (Hanshaw et al, 1965).…”

Measles virus‐specific IgM antibodies in sera from patients with chronic active hepatitis

“…The occurrence of very high antibody titres against rubella and measles virus in sera from patients with chronic active hepatitis (CAH) not caused by hepatitis B virus was originally described by Closs et a1 [ 1971,19731 and later confirmed by others [Triger et al, 1972;Laitinen and Vesikari, 19721. We have previously studied the specificity of the antibodies to measles virus antigens and shown that the major antibodies in sera from patients with CAH are directed against the virus nucleoprotein and the haemagglutinin [Christie and Haukenes, 1979;Christie et al, 19821.…”