Recent Advances in Momordica charantia: Functional Components and Biological Activities

Jia, Shijie; Shen, Mingyue; Zhang, Fan; Xie, Mingyong

doi:10.3390/ijms18122555

Cited by 297 publications

(219 citation statements)

References 172 publications

(191 reference statements)

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“…to list a few. 31 In the present study, the mechanism of CuO NRs synthesis can be hypothesized and explained by using the phenolic content of fruit extract of M. charantia as they are known to have the high reducing ability. 32,33 It is well documented that the gallic acid is present as one of the key phenolic components in M. charantia fruit extract which might facilitate the reduction of Cu(OH) 2 to nano-sized CuO.…”

Section: Results and Discussion Green Synthesis Of Cuo Nrs And Uv-vismentioning

confidence: 99%

Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from Momordica charantia

Qamar¹,

Rehman²,

Chauhan³

et al. 2020

IJN

109

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Background: In the emerging field of nanotechnology, copper oxide (CuO) nanomaterials are considered to be one of the most important transition metal oxides owing to its fascinating properties. Its synthesis from green chemistry principles is gaining importance as next-generation antibiotics due to its simplicity, eco-friendliness, and cost-effectiveness. In the present study, CuO nanorods (CuO NRs) were synthesized from the aqueous fruit extract of Momordica charantia and characterized using different analytical techniques. Further, the biomedical therapeutic potential was evaluated against multi-drug resistant microbial strains. Materials and Methods: To synthesize CuO NRs, 0.1M of CuSO 4 .5H 2 O solution was added to aqueous extract of Momordica charantia in a 1:3 (v/v) ratio (pH=11) and heated at 50°C followed by washing and drying. The synthesized CuO NRs were subjected to characterization using different analytical techniques such as UV visible spectroscopy, zeta sizer equipped with zeta potential, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) equipped with energydispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). Further, the application as a biomedical therapeutic potential was evaluated in vitro using well diffusion method against eleven multidrug-resistant clinical bacterial strains, a fungus-Trichophyton rubrum and in ovo against the R 2 B virus using haemagglutination (HA) test. Results: Characterization was preliminarily done by the spectral study that confirms the absorbance band at 245nm. FTIR analysis at 628 cm −1 peak identified copper oxide vibration. SEM analysis revealed agglomerated particle clusters. However, with TEM clear nanorods of average diameter of 61.48 ± 2 nm were observed. EDAX confirmed CuO formation while XRD showed a typical monoclinic structure with 6 nm crystallite size. Biological screening of CuO NRs showed significant results against both in vitro and in ovo methods. Significant inhibitory activity (p<0.0001) was noted against most of the resistant human pathogenic strains including both Gram-positive and Gram-negative bacteria. The highest efficacy was observed against Bacillus cereus with a 31.66 mm zone of inhibition. Besides, the therapeutic potential of CuO NRs against Corynebacterium xerosis, Streptococcus viridians and R 2 B strain of Newcastle disease is reported for the first time.Conclusion: Based on the present results, it could be expected that green synthesized CuO NRs would find potential applications in the field of nanomedicine.

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Section: Results and Discussion Green Synthesis Of Cuo Nrs And Uv-vismentioning

confidence: 99%

Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from Momordica charantia

Qamar¹,

Rehman²,

Chauhan³

et al. 2020

IJN

109

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“…and Trichosanthes kirilowii Maximowicz (Jia, Shen, Zhang, & Xie, 2017;Kaushik, Aeri, & Mir, 2015;Ma et al, 2014). CuB has a wide range of pharmacological effects such as anti-inflammatory, antiviral, anticancer, and other activities (Garg, Kaul, & Wadhwa, 2018;Chen, Chiu, Nie, Cordell, & Qiu, 2005;Jayaprakasam, Seeram, & Nair, 2003).…”

mentioning

confidence: 99%

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells

Liang

Zhang

Yuan

et al. 2018

Phytotherapy Research

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Changes in cellular biomechanical properties affect cell migration and invasion. The natural compound Cucurbitacin B (CuB) has potent anticancer activity; however, the mechanism underlying its inhibitory effect on breast cancer metastasis needs further study. Here, we showed that low‐dose CuB inhibited adhesion and altered the viscoelasticity of breast cancer cells, thereby, reducing cell deformability. In vitro and in vivo experiments proved that CuB effectively inhibited the migration and invasion of breast cancer cells. Further studies have found that CuB downregulated the expression of F‐actin/vimentin/FAK/vinculin in breast cancer cells, altering the distribution and reorganization of cytoskeletal proteins in the cells. CuB inhibited signaling by the Rho family GTPases RAC1/CDC42/RhoA downstream of integrin. These findings indicate that CuB has been proven to mediate the reorganization and distribution of cytoskeletal proteins of breast cancer cells through RAC1/CDC42/RhoA signaling, which improves the mechanical properties of cell adhesion and deformation and consequently inhibits cell migration and invasion.

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“…The placebo ingredients included Momordica charantia L. in order to mimic the bitter taste of the TM. This plant is not inactive, having shown anti‐inflammatory effects, so this may have affected the result for the placebo group. In the study with the highest FEV 1 % scores at baseline, there were no significant changes within either group or between groups at EoT.…”

Section: Resultsmentioning

confidence: 99%

Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

Clyne

Yang

et al. 2019

Int J Clin Pract

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Background Traditional medicines (TMs) adjunctive to conventional medications are widely used for asthma in east‐Asia and have gained popularity in western countries. Objective To assess the efficacy and safety of TMs for asthma in children and adults based on placebo‐controlled trials in order to inform physicians and assist them in discussions with patients. Methods Seventeen electronic databases were searched. Participants had acute or chronic asthma. Interventions included orally administered traditional medicines used in east‐Asia. Outcomes included lung function, symptoms, quality of life, exacerbations, medication use and safety. RevMan 5.3 (random effect model) was used for meta‐analysis. Baseline values were assessed for balance and asthma severity. Within‐group changes were calculated to assess minimal clinically important difference (MCID). Results Eighteen studies (2080 participants) were included. All combined TMs with conventional medicines. The single study of acute asthma (n = 300) showed an improvement. For chronic asthma, severity at baseline ranged from very mild to severe. When asthma was mild, significant differences in lung function (FEV1%, PEF/R) were not detectable. When participants had moderate and/or severe asthma at baseline improvements were more evident. For measures of lung function, improvements within the TM groups tended to be greater when the asthma was more severe. Some studies showed MCIDs. No serious adverse events or interactions were reported but safety data were incomplete. Conclusions The application of certain traditional herbal medicines used in east‐Asia as adjuncts to conventional medications improved outcomes in acute and chronic asthma, but most evidence was based on single trials. Therefore, no single TM could be recommended. Effect sizes varied according to asthma severity at baseline. Future studies should consider baseline severity when enrolling participants.

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Recent Advances in Momordica charantia: Functional Components and Biological Activities

Cited by 297 publications

References 172 publications

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells

Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

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