Recherches sur l'ozonation du cholestérol

Abstract

Les auteurs qui se sont occupés de l'ozonation du cholestérol étant parvenus à des résultats très divergents quant au nombre de molécules d'ozone fixèes pour la formation d'un ozonide, nous avons repris l'étude de problème en nous servant d'une méthode d'ozonation quantitative, avec représentation graphique des proportion d'ozone consommeés aux différentes étapes successives de l'ozonation.

The Reactions Of Ozone With Organic Compounds

“…The tendency to form such systems would be much greater than the tendency to form b: x = 4 COOCHa an ozonide of a cyclohexene derivative, which would have seven-and eightmembered rings (e.g., XXIIb). Cyclohexene, 1 -methylcyclohexene, 1,2-dimethylcyclohexene, cycloheptene, cyclooctene, and cholesterol yield largely polymeric ozonides and/or peroxides (72,73,204,207,209). The yields of monoozonides from unsaturated five-membered ring systems in which there is only one or no substituent on the atoms of the double bond are much lower than the yields of monoozonides from the corresponding systems with substituents on both atoms of the double bond (204,207).…”

“…Sodium or potassium iodide (37,38,208,211), zinc or magnesium and water or acetic acid (233, 296, 307, 322, 520, 564), and catalytic reduction (36,297,530,537,597) appear to be used most frequently. Others are sodium bisulfite (135, 467), sulfur dioxide (595), stannous chloride (517), Raney nickel (72,189), and formaldehyde (517). Sodium bisulfite is useful in cases where one of the reduction products is an aldehyde and it is necessary to separate it from another product (467).…”

Synthese und Abbau von 1‐(5‐Nitro‐2‐thiazolyl)‐2‐imidazolidinon und Derivaten

“…Die an den Kohlenstoffatomen des Thiazol-oder Imidazol-Ringes durch Alkyloder Aryl-Gruppen substituierten Derivate des l-(5-Nitro-2-thiazolyl)-2-imidazolidinons (Tabelle 2) unter Verwendung von Chloracyl-isocyanat anstelle des (2-Chlorathyl)-isocyanates das (5-Nitro-2-thiazolyl)-hydantoin (22) synthetisieren. …”

Stereospezifische Synthese und Isomerisierung der 10‐Chlor‐decahydroisochinoline. Decahydroisochinoline. IV. Teil

“…Das atherunlosliche Triathylamin-hydrochlorid wurde abfiltriert und die Atherlosung eingedampft. Zuriick blieben 413 mg (96%) 3/3-Acetoxy-d6-cholesten (9a) [22] (Cholesterylacetat), welches nach Umkristallisation aus AtherlAthanol bei 113-114" schmolz (Lit. [ZZ] : 114O).…”