Recommendations for the treatment of osteomyelitis

Lima, Ana Lúcia Munhoz; Oliveira, Priscila Rosalba Domingos de; Carvalho, Vladimir Cordeiro de; Cimerman, Sérgio; Savio, Eduardo

doi:10.1016/j.bjid.2013.12.005

Cited by 117 publications

(96 citation statements)

References 59 publications

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“…This type of infection is associated with a high morbidity and occurs when a complicated bone fracture is exposed to bacteria . Traditional treatment modalities for osteomyelitis involve systemic administration of antibiotics for several weeks to months, which is often associated with toxicity, antibiotic resistance, and recurrence of infections . In addition, bone infections are frequently caused by more than one type of bacteria, which requires the delivery of different types of antibiotics from a single carrier to avoid ineffective treatment and antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

Song

Odekerken

Löwik

et al. 2015

Macromolecular Bioscience

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In this study, we investigated the fundamental relationship between the physicochemical characteristics of antibiotics and the kinetics of their release from gelatin nanospheres. We observed that antibiotics of high molecular weight (colistin and vancomycin) were released in a sustained manner from oppositely charged gelatin carriers for more than 14 d, as opposed to antibiotics of low molecular weight (gentamicin and moxifloxacin) which were released in a burst-like manner. The release kinetics of positively charged colistin strongly correlated with the rate of the enzymatic degradation of gelatin. To elucidate the differences among release kinetics of antibiotics, we explored the mechanism of interactions between antibiotics and gelatin nanospheres by monitoring the kinetics of release of antibiotics as a function of pH, ionic strength, and detergent concentrations. These studies revealed that the interactions between antibiotics and gelatin nanospheres were mainly dominated by (i) strong electrostatic forces for colistin; (ii) strong hydrophobic and electrostatic forces for vancomycin; (iii) weak electrostatic and hydrophobic forces for gentamicin; and (iv) weak hydrophobic forces for moxifloxacin. These results confirm that release of antibiotics from gelatin nanospheres strongly depends on the physicochemical characteristics of the antibiotics.

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Section: Introductionmentioning

confidence: 99%

Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

Song

Odekerken

Löwik

et al. 2015

Macromolecular Bioscience

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“…Culture of biopsy from the involved bone is the main diagnostic technique for ruling out osteomyelitis 10, 11, and blood cultures are generally only essential in hematogenous osteomyelitis. Some authors have proposed the gathering of at least three bone samples to increase the positivity rate 12. In the published cases of osteomyelitis by H. parainfluenzae, diagnosis was by blood culture in only one case, being based on aspiration biopsy or intraoperative tissue/bone sample in others.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery is necessary in almost all cases, especially when an abscess is present 12. Drainage and debridement are performed after confirmation of the diagnosis and are the keys to successful treatment.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Osteomyelitis Caused by Haemophilus Parainfluenzae

Cobo

Jiménez

Rodríguez‐Grangér

et al. 2017

J. Bone Joint Infect.

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Haemophilus parainfluenzae is a rare cause of bone and joint infections. We report a case of calcaneal osteomyelitis due to this microorganism with a review of all published. A 23-year-old woman presented with a 1-month history of pain and inflammation in the calcaneus area. Osteomyelitis was suspected at this location based on computed tomography images. Culture of six bone biopsies and surrounding tissue resulted in the isolation of H. parainfluenzae. Surgical drainage and debridement was performed, and antibiotic treatment was prescribed, resolving the infection.

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“…Na osteomielite aguda, ocorre um processo inflamatório não circunscrito de rápido curso evolutivo, sendo o paciente portador de febre, leucocitose, linfoadenopatia, dor e tumefação 12 e sem qualquer significância radiográfica 15,16 . Já a osteomielite crônica pode ser primária, surgindo como infecção de menores proporções clínicas além de atenuação dos sinais flogísticos principais como dor branda, presença de seqüestro ósseo 17 . A forma secundária ocorre a partir de uma osteomielite aguda que não foi tratada ou recebeu inadequada terapêutica 18 .…”

Section: Introductionunclassified

Osteomielite crônica mandibular: relato de caso

Masocatto¹,

Oliveira²,

Mendonça³

2017

Arch Health Invest

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ResumoAs osteomielites dos maxilares são bastante comuns nos países em desenvolvimento, sendo que em alguns casos o diagnóstico, assim como a terapêutica, são por vezes comprometidos em virtude da variedade microbiana associada a essas condições clínicas além de terapêuticas incorretas. Assim, foi objetivo dos autores discutir os principais aspectos de diagnóstico sejam eles clínicos e imaginológicos assim como as terapêuticas associadas por meio de um caso clínico de paciente de 42 anos de idade do gênero masculino queixando-se de dor em região mandibular esquerda e presença de secreção purulenta que persistia há mais de um mês. Ao exame clínico extrabucal pôde-se constatar a presença de três fístulas em região de ângulo mandibular esquerdo. A ortopantomografia evidenciou lesões líticas e espessamento cortical com aspecto de "roído por traça" associada a áreas compatíveis com seqüestros ósseos. Baseado nas características anteriores, o diagnóstico foi de osteomielite crônica mandibular. A terapia incluiu combinação de antibioticoterapia e procedimentos cirúrgicos como a sequestrectomia, debridamento, decorticação com resultados satisfatórios. Assim, o tratamento cirúrgico local adquire uma grande importância no resultado da terapia, associado com o uso de antimicrobianos como coadjuvantes, fundamental importância no êxito da terapêutica, sem deixar de notar a importância de um tratamento precoce para o sucesso da mesma. Descritores: Osteomielite; Bactérias; Diagnóstico; Maxila; Mandíbula. AbstractOsteomyelitis of the jaws are quite common in developing countries, and in some cases the diagnosis and therapy are sometimes compromised because of the variety microbial associated with these clinical conditions associated with therapeutic incorrect. Thus, it was the objective of the authors discuss the main aspects of diagnosis whether clinical and imaging as well as therapeutic linked through a clinical case of a 42 year-old male complaining of pain in left mandibular region and the presence of secretion pus that has persisted for over 1 month. On examination Clinical headgear could be verified the presence of 3 fistulas in left mandibular angle region. The panoramic radiography showed osteolytic lesions and cortical thickening with the appearance of "motheaten" associated with areas compatible with bone sequestration. Based on previous features, the diagnosis was chronic osteomyelitis of the mandible. Therapy included combination of antibiotics and procedures of sequestrectomy surgical, debridement, decortication with satisfactory results. Thus, treatment surgical site becomes more important in result of therapy, associated with the use of antimicrobials as adjuncts, fundamental importance to the success of therapy without noticing the importance of early treatment for successful therapy. Descriptors: Osteomyelitis; Bacteria; Diagnosis; Maxilla; Mandible. ResumenLa osteomielitis de los maxilares son muy comunes en países en desarrollo, y en algunos casos, el diagnóstico y la terapia a veces se ve comprometida debid...

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Recommendations for the treatment of osteomyelitis

Cited by 117 publications

References 59 publications

Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

A Rare Case of Osteomyelitis Caused by Haemophilus Parainfluenzae

Osteomielite crônica mandibular: relato de caso

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