Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women

Abdullahi, Hala; Osman, Abdelgadir H.; Rayis, Duria A.; Gasim, Gasim I.; Imam, Abdulmutalab M

doi:10.1186/1746-1596-9-29

Cited by 38 publications

(51 citation statements)

References 25 publications

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“…In contrast to the literature, we did not observe any increase in Hct and any decrease in PLT, especially in severe form of preeclampsia, despite we expected to see (14,43). Conflicting results may be mainly due to the small number of subjects in severe and mild preeclampsia groups.…”

Section: Discussioncontrasting

confidence: 55%

Erythrocyte Indices in Patients with Preeclampsia

Avcıoğlu¹,

Sezer²,

Altınkaya³

et al. 2015

meandros

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Objective: The purpose of study was to investigate erythrocyte indices in patients with preeclampsia. Materials and Methods:The study population consisted of 102 patients with preeclampsia (49 mild, 53 severe preeclampsia) and 98 control pregnant patients. For the entire study population, red blood cell indices, including baseline mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and red blood cell (RBC) were measured by using an automatic blood counter. Results: In the preeclampsia group, the median RDW was 15% (13.8-16.57), whereas in the control group it was 13.9% (13-15.6) (p<0.01). On the other hand, the mean MCV value was 80.42±7.86 (fL) in preeclampsia group and 83.88±2.31 (fL) in control group (p=0.003). Besides, the mean MCHC value was 33.66±1.71 (g/dL) in preeclampsia group and 33.09±1.48 (g/dL) in control group (p=0.012). However MCH and RBC values were not statistically different between the groups. (p>0.05) Moreover, subgroup analysis revealed that RDW levels were significantly increased in preeclampsia subjects than in mild preeclampsia patients (15.4% (13.9-17.45) vs 14.3% (13.7-15.7), p=0.031), MCV levels were decreased (78.81±7.91 (fL) vs 82.16± 7.43 (fL), p=0.03), RBC values were increased (4.16 (3.79-4.85)x(10 12 /L) vs 3.82 (3.45-4.34)x(10 12 /L), (p=0.006)) in patients with severe preeclampsia when compared to the patients with mild preeclampsia. In the receiver operator characteristic (ROC) analysis of subjects with and without preeclampsia, RDW and MCV showed high predictive values (p<0.01). Besides, in ROC analysis of preeclampsia patients with different severities, RDW and RBC showed the ideal predictive values (p=0.006, p=0.031, respectively). Conclusion: Our study results revealed that among the red blood cell indices, only increased RDW values were associated with both the presence and the severity of preeclampsia.Amaç: Bu çalışmanın amacı preeklampsi tanısı konmuş hastalarda eritrosit indekslerini araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 102 preeklampsi (49 hafif ve 53 şiddetli preeklampsi olmak üzere) ve 98 kontrol hastası dahil edilmiştir. Tüm çalışma grubunda eritrosit indeksleri olan ortalama korpuskular hacim (MCV), ortalama korpuskular hemoglobin (MCH), ortalama korpuskular hemoglobin konsantrasyonu (MCHC), eritrosit sayımı ve eritrosit dağılım genişliği değerleri otomatik kan sayım cihazı ile ölçüldü.Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

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Section: Discussioncontrasting

confidence: 55%

Erythrocyte Indices in Patients with Preeclampsia

Avcıoğlu¹,

Sezer²,

Altınkaya³

et al. 2015

meandros

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“…In Sudan, several aspects of preeclampsia were investigated (19–23); however, there were no published data on thyroid function/antibodies in preeclamptic patients. This study aimed to investigate thyroid function (TSH, free T3, and free T4)/antibodies (anti-TPO and anti-TG) in patients with preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

et al. 2015

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Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan. A case–control study was conducted at Medani Hospital, Sudan, to investigate thyroid function/antibodies in preeclampsia. The sociodemographic, medical history was gathered using questionnaires. Thyroid hormones [thyroid-stimulating hormone (TSH), free tri-iodothyronine (T3), and free thyroxine (T4)] and anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies were measured using ELISA. The three groups [controls, mild, and severe preeclampsia (SP) (55 women in each arm)] were matched in age and parity. While median (interquartile range) of TSH was significantly lower, both free T3 and free T4 levels were significantly higher in women with preeclampsia than in the healthy controls. There was no significant difference in the TSH levels in women with MP and SP. In comparison with women with MP, women with SP had significantly higher levels of free T3 and significantly lower levels of free T4. While anti-TPO antibodies were significantly higher, anti-TG antibodies were significantly lower in women with preeclampsia. Likewise, anti-TPO antibodies were significantly higher and anti-TG antibodies were significantly lower in women with SP than in women with MP. In linear regression, preeclampsia was significantly associated with TSH (−0.675 IU/ml, P = 0.009), free T3 (0.977 pg/ml, P < 0.001), and free T4 (0.186 ng/dl, P < 0.001) levels. In contrast to anti-TG antibodies and TSH, Sudanese patients with preeclampsia had higher levels of T3 and T4 hormones and anti-TPO antibodies irrespective of parity, gestational age, and hemoglobin levels.

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“…On the contrary, Abdullahi et al including 65 cases and controls matched in their basic characteristics found no difference in the mean (SD) RDW-CV between women with preeclampsia and controls (14.5% ± 1.8 vs. 14.4% ± 1.4, P = 0.710). In this study, there was also no difference in the mean RDW between women with mild and severe preeclampsia (14.7% ± 1.9 vs. 13.9% ± 1.4, P = 0.144) and, in logistic regression, there was no association between RDW and preeclampsia (OR = 0.9, 95% CI = 0.7 - 1.1, P = 0.952) ( 21 ). Overall, these findings suggest that RDW may be increased in preeclampsia, especially in severe cases, but such an increase remains to be better quantified, and evaluated in terms of clinical applicability, given the fragmented data reported on the sensitivity, specificity and other diagnostic accuracy parameters of RDW in the studies published so far.…”

Section: Discussionmentioning

confidence: 58%

Red blood cell distribution width in pregnancy: a systematic review

et al. 2018

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Anisocytosis has been associated with the severity and prognosis of several acute and chronic diseases, as well as physiological conditions such as pregnancy. Anisocytosis is quantified by the red blood cell distribution width (RDW), expressed as the ratio, multiplied by 100, between the standard deviation (SD) of red blood cell volumes and the mean corpuscular volume, or as the SD of erythrocyte volumes (RDW-SD). The aim of the present review was to report the state of the art on the physiological values and the putative diagnostic and prognostic roles of RDW in complicated pregnancy. Literature research for articles published in the last ten years was conducted in Pubmed, Web of Science, ClinicalTrials.gov, and Scopus databases. Abstracts were independently screened by two investigators. If relevant, full articles were retrieved. References, in these articles, citing relevant reviews or original studies were also accessed to identify additional eligible studies. Any disagreement between the reviewers was resolved by a third investigator. A total of 28 studies were included in the review. These studies reported changes in RDW values during physiological pregnancy, and associations between the RDW and several pregnancy complications including anaemia, preeclampsia, gestational diabetes, and recurrent miscarriage. This review provides background information for establishing physiological and pathological RDW values in pregnancy for diagnostic and prognostic use in clinical practice.

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Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women

Cited by 38 publications

References 25 publications

Erythrocyte Indices in Patients with Preeclampsia

Erythrocyte Indices in Patients with Preeclampsia

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

Red blood cell distribution width in pregnancy: a systematic review

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