Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study

Pounis, George; Costanzo, Simona; Bonaccio, Marialaura; Castelnuovo, Augusto Di; Curtis, Amalia De; Ruggiero, Emilia; Persichillo, Mariarosaria; Cerletti, Chiara; Donati, Maria Benedetta; Gaetano, Giovanni de; Iacoviello, Licia; Vermylen, Jos; Carrasco, Ignacio De Paula; Giampaoli, Simona; Spagnuolo, Antonio; Assanelli, Deodato; Centritto, Vincenzo; Spagnuolo, Pasquale; Staniscia, Dante; Bonanni, Americo; Lorenzet, Roberto; Mascioli, A.; Olivieri, Marco; Rotilio, Domenico; Gianfagna, Francesco; Giacci, Maurizio; Padulo, Antonella; Petraroia, Dario; Magnacca, Sara; Marracino, Federico; Spinelli, Maria; Silvestri, Christian; Dell’Elba, Giuseppe; Grippi, Claudio; Lucia, Francesca De; Vohnout, Branislav; Verna, Angelita; Lillo, Maura Di; Stefano, Irene Di; Pampuch, Agnieszka; Pannichella, Agostino; Vizzarri, Antonio Rinaldo; Barbato, Daniela; Bracone, Francesca; Giorgio, Carmine; Panebianco, Simona; Chiovitti, Antonello; Caccamo, Sergio; Caruso, Vanesa; Cugino, Daniela; Zito, Francesco; Ferri, Alessandra; Castaldi, Concetta; Mignogna, Marcella; Guszcz, Tomasz; Barisciano, Paola; Buonaccorsi, Lorena; Centritto, Floriana; Cutrone, Antonella; Fanelli, Francesca; Santimone, Iolanda; Sciarretta, Anna; Sorella, Isabella; Plescia, Emanuela; Molinaro, Alessandra; Cavone, C.; Galuppo, Giovanna; D'Angelo, Dolores; Ramacciato, Rosanna

doi:10.1016/j.nut.2017.11.012

Cited by 35 publications

(25 citation statements)

References 28 publications

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“…Cardiovascular diseases (CVDs) are a major contributor to morbidity and mortality in developed countries (Organization, ). Towards the end of the 20th century, a large number of clinical trials and epigenetics studies have strongly correlated the long‐term consumption of a polyphenol‐rich diet with protection against chronic diseases such as cancers and CVDs (Arts & Hollman, ; Mitjavila & Moreno, ; Pounis et al, ). The risk of CVD was reduced by 46% in individuals with a diet rich in polyphenols (Tresserra‐Rimbau et al, ).…”

Section: Introductionmentioning

confidence: 99%

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Man

Xia

Daiber

et al. 2019

British J Pharmacology

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Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long‐term consumption of polyphenol‐rich diet protects against chronic diseases such as cancers and cardiovascular diseases. Current cardiovascular studies have also suggested an important role of gut microbiota and circadian rhythm in the pathogenesis metabolic and cardiovascular diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with circadian clocks. In this article, we summarize recent findings, review the molecular mechanisms and the potential of polyphenols as dietary supplements for regulating gut microbiota and circadian rhythms, and discuss future research directions. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Introductionmentioning

confidence: 99%

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Man

Xia

Daiber

et al. 2019

British J Pharmacology

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“…The EPIC-Spain study also found null relationships between dietary flavonoid or lignan intake and mortality from cancer [29]. In contrast, recent cohort study in Italy showed a lower risk for cancer as well as all-cause and cardiocerebrovascular mortality by polyphenol-rich diet [9]. The association between total polyphenol intake and the risk of cancer mortality remains inconclusive.…”

Section: Discussionmentioning

confidence: 98%

“…More recent epidemiological studies used a holistic polyphenol database such as the Phenol-Explorer database [6]. Several studies have estimated dietary intake of total polyphenol and suggested that polyphenol consumption contributes to a reduction in the risks of chronic diseases such as cardiovascular diseases (CVDs) [7,8] and some cancers [9], in addition to all-cause mortality [10,11]. However, the relationship between dietary total polyphenol intake and mortality has not been studied in a Japanese population or in Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study

Taguchi

Kishimoto

Fukushima³

et al. 2019

Eur J Nutr

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Purpose Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects' total polyphenol intake and their mortality from all causes, cardiovascular disease (CVD), cancer, and other causes of death in a population-based cohort study in Japan. Methods A total of 29,079 residents of Takayama City, Japan were analyzed. Their dietary intake was assessed using a validated semi-quantitative food-frequency questionnaire (FFQ) in 1992. Mortality was ascertained over the subsequent 16 years. The dietary polyphenol intake was calculated by matching the subjects' food consumption data with our original polyphenol content database. Results A total of 5339 deaths occurred during the follow-up. After multivariable adjustment, the highest quartile of total polyphenol intake compared with the lowest quartile was significantly associated with a lower risk of all-cause mortality (HR: 0.93, 95% CI: 0.82-0.99, p trend = 0.003). The subjects in the highest quartile showed significantly lower CVD mortality compared to those in the lowest quartile, and among the types of CVD mortality, a strong inverse association was observed for stroke mortality. Inverse associations were also observed for mortality from other causes, specifically digestive disease. The total polyphenol intake was not significantly associated with the risk of cancer mortality. Conclusions The results of this prospective study indicate that dietary total polyphenol intake in Japanese is inversely associated with all-cause mortality and mortality from cardiovascular and digestive diseases.

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“…Polyphenols are bioactive compounds that can be divided into 4 groups: flavonoids, phenolic acids, stilbenes, and lignans (1). In recent years, many studies have underlined the potential health benefit of dietary polyphenols as anti-inflammatory effects on atherosclerosis, type 2 diabetes, cancer, and mortality (2)(3)(4)(5)(6). Further research is needed since 1 meta-analysis showed mostly nonlinear associations in the prevention of type 2 diabetes (7) and a systematic review detected inconsistent effects of flavonoid consumption towards inflammation depending on polyphenol source and type of high-risk populations (8).…”

Section: Introductionmentioning

confidence: 99%

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

Wisnuwardani

Henauw

Ferrari³

et al. 2020

The Journal of Nutrition

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Background Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents. Objective This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents. Methods In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5–17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor β1 (TGF-β1), TNF-α, IFN-γ, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-α + zIL-6 + zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides. Results The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (β = −0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (β = −0.12, P = 0.017) and flavonoid (β = −0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (β = 0.09 P = 0.049) and stilbene (β = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-γ with lignan intake (β = −0.10, P = 0.034; β = −0.09, P = 0.049; β = −0.11, P = 0.023). Conclusions The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured.

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Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study

Cited by 35 publications

References 28 publications

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

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