Reduced Plasma Dehydroepiandrosterone Concentrations in Alzheimer's Disease

Sunderland, Trey; Merril, C.R.; Harrington, Michael G.; Lawlor, B.A.; Molchan, SusanE.; Martínez, Rick A.; Murphy, DennisL

doi:10.1016/s0140-6736(89)90700-9

Cited by 128 publications

(57 citation statements)

References 8 publications

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“…Indeed, the serum concentration of DHEA-S in Alzheimer's disease (AD) has been reported to be markedly reduced as compared with controls [5,6]. A decreased concentration of DHEA may fail to protect partly degenerated or at-risk brain cells [5].…”

Section: Dehydroepiandrosteronementioning

confidence: 99%

“…DHEA-S has also been proposed as a possible marker for AD since a marked reduction in the plasma concentration of DHEA-S in patients with AD compared with normal controls was first reported by Sunderland et al [5]. Five subsequent reports [8][9][10][11][12] have not supported these findings, while one report by Nasman et al [6] studying 45 AD patients, the largest sample size so far, has demonstrated a lower concentration of serum DHEA-S not only in patients with AD but also in patients with multi-infarct dementia (MID).…”

Section: Statisticsmentioning

confidence: 99%

See 1 more Smart Citation

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

et al. 1996

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Section: Dehydroepiandrosteronementioning

confidence: 99%

Section: Statisticsmentioning

confidence: 99%

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

et al. 1996

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“…Furthermore, reduced circulating DHEA sulfate and pregnenolone sulfate levels have been linked with decreased cognitive function in humans. Studies have also reported reduced circulating DHEA sulfate levels in patients with Alzheimer's disease and multi-infarct dementia [65,66]. These findings, together with the detection of SULT1A1, SULT1E1, SULT2A1, SULT2B1 and STS in the fetal and adult brain, suggests that sulfonation and deconjugation of neurosteroids contributes to neurodevelopment and maintenance of brain function.…”

Section: Physiological Roles Of Sulfonated Steroidsmentioning

confidence: 85%

The Biological Roles of Steroid Sulfonation

Dawson¹

2012

Steroids - From Physiology to Clinical Medicine

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“…Several other clinical studies have reported lower serum concentrations of DHEAS in patients with AD [14,[118][119][120], a reduction paralleled by decreases in the brain and cerebral spinal fluid [121,122]. For instance, Weill-Engerer and colleagues [108] reported that not only are brain levels of DHEAS significantly lower in AD, but also the lower levels are inversely correlated with the presence of phosphorylated tau and β-amyloid.…”

Section: Dhea and Admentioning

confidence: 97%

Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease

Quinn¹,

Robinson²,

Walker³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal growth and differentiation, and neuroprotection. Highlighting the potential health significance of DHEA and DHEAS in humans, serum concentrations decrease steadily with age, with lowest concentrations present at the time many diseases of aging and neurodegeneration become apparent. This temporal association has led to the suggestion that pathology associated with cognitive decline, age-related neurological disorders such as Alzheimer's disease, dementia, amyotrophic lateral sclerosis (ALS), and adult onset schizophrenia may, in part at least, be attributed to decreased secretion of DHEA. Animal studies suggest neuroprotective functions for DHEA and DHEAS through reduction of glutamate-induced excitotoxicity. Reduced myelin loss and reactive gliosis after spinal cord injury by DHEA treatment also suggest a role for DHEA in the treatment of white matter pathologies such as multiple sclerosis. In this chapter, we discuss the physiological roles of DHEA and DHEAS in the central nervous system (CNS), their potential as neuroprotective hormones with reference to documented effects on excitotoxicity and oxidative stress, and their anti-glucocorticoid actions during chronic stress. The potential for metabolic derivatives of DHEA, such as estrogens and testosterone on brain function, and their contribution to neurodevelopment and neurodegenerative conditions are also discussed.

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Reduced Plasma Dehydroepiandrosterone Concentrations in Alzheimer's Disease

Cited by 128 publications

References 8 publications

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

The Biological Roles of Steroid Sulfonation

Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease

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