Reduction of parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges

Schrag, Anette; Schelosky, Ludwig; Scholz, Udo; Poewe, Werner

doi:10.1002/1531-8257(199903)14:2<252::aid-mds1009>3.0.co;2-n

Cited by 66 publications

(34 citation statements)

References 22 publications

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“…Most patients tend to present with an action tremor more pronounced on the side of the body that is more affected by the other signs of parkinsonism 14 . Also, action tremor may respond to the same interventions used to treat its rest correlate 15 , suggesting a similar underlying pathological basis. On the other hand, tremor analysis of cases of action tremor in PD showed that some cases present findings similar to exacerbated physiological tremor 14,15 .…”

Section: Discussionmentioning

confidence: 99%

Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

Cichaczewski

Munhoz²,

Maia

et al. 2014

Arq. Neuro-Psiquiatr.

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Tremor in essential tremor (ET) and Parkinson's disease (PD) usually present specific electrophysiologic profiles, however amplitude and frequency may have wide variations. Objective: To present the electrophysiologic findings in PD and ET. Method: Patients were assessed at rest, with posture and action. Seventeen patients with ET and 62 with PD were included. PD cases were clustered into three groups: predominant rest tremor; tremor with similar intensity at rest, posture and during kinetic task; and predominant kinetic tremor. Results: Patients with PD presented tremors with average frequency of 5.29±1.18 Hz at rest, 5.79±1.39 Hz with posture and 6.48±1.34 Hz with the kinetic task. Tremor in ET presented with an average frequency of 5.97±1.1 Hz at rest, 6.18±1 Hz with posture and 6.53±1.2 Hz with kinetic task. Seven (41.2%) also showed rest tremor. Conclusion: The tremor analysis alone using the methodology described here, is not sufficient to differentiate tremor in ET and PD.

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Section: Discussionmentioning

confidence: 99%

Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

Cichaczewski

Munhoz²,

Maia

et al. 2014

Arq. Neuro-Psiquiatr.

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“…An understanding of the intrinsic mechanisms that are involved in spike generation and patterning is central to determining the origin of the pause response detected during unit recordings from TANs in vivo. Furthermore, the possibility that oscillatory activity observed in parkinsonian states might arise from alterations of the intrinsic membrane properties has potential clinical relevance because of the known efficacy of cholinergic antagonists in the treatment of Parkinson's disease (Hingtgen and Siemers, 1998;Schrag et al, 1999).…”

Section: Abstract: Tans; Tonic Firing; Rhythmic Bursting; Spike Sequmentioning

confidence: 99%

Intrinsic Membrane Properties Underlying Spontaneous Tonic Firing in Neostriatal Cholinergic Interneurons

2000

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Neostriatal cholinergic interneurons produce spontaneous tonic firing in the absence of synaptic input. Perforated patch recording and whole-cell recording combined with calcium imaging were used in vitro to identify the intrinsic membrane properties underlying endogenous excitability. Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I h ), which together ensured that there was no zero current point in the subthreshold voltage range. Blockade of sodium channels or I h established a stable subthreshold resting membrane potential. A tetrodotoxinsensitive region of negative slope conductance was observed between approximately Ϫ60 mV and threshold (approximately Ϫ50 mV) and the h-current was activated at all subthreshold voltages.Calcium imaging experiments revealed that there was minimal calcium influx at subthreshold membrane potentials but that action potentials produced elevations of calcium in both the soma and dendrites. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels. Blockade of bigconductance channels caused spike broadening. Application of apamin, which blocks small-conductance channels, abolished the slow spike afterhyperpolarization (AHP) and caused a transition to burst firing.In the absence of synaptic input, a range of tonic firing patterns are observed, suggesting that the characteristic spike sequences described for tonically active cholinergic neurons (TANs) recorded in vivo are intrinsic in origin. The pivotal role of the AHP in regulating spike patterning indicates that burst firing of TANs in vivo could arise from direct or indirect modulation of the AHP without requiring phasic synaptic input.

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“…Motion sensor technology has previously been leveraged for capturing and quantifying PD motor symptoms (Costa et al, 2010; Giuffrida et al, 2009; Heldman et al, 2011; Manson et al, 2000; Patel et al, 2009; Rigas et al, 2009; Schrag et al, 1999; Weiss et al, 2010). However, home monitoring applications require high patient compliance, a critical element for validation of home testing results and achieving acceptance in the clinical community.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of home-based automated Parkinson's disease motor assessment

Mera

Heldman

Espay

et al. 2012

Journal of Neuroscience Methods

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Reduction of parkinsonian signs in patients with Parkinson's disease by dopaminergic versus anticholinergic single-dose challenges

Cited by 66 publications

References 22 publications

Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

Intrinsic Membrane Properties Underlying Spontaneous Tonic Firing in Neostriatal Cholinergic Interneurons

Feasibility of home-based automated Parkinson's disease motor assessment

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