Regeneration of gingival tissue using in situ tissue engineering with collagen scaffold

Hatayama, Takahide; Nakada, Akira; Nakamura, Hiroki; Mariko, Wakatsuki; Tsujimoto, Gentarou; Nakamura, Tatsuo

doi:10.1016/j.oooo.2017.05.471

Cited by 14 publications

(18 citation statements)

References 29 publications

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“…In the context of GR healing, the type of recession greatly influences the effect of Col in the healing process. Hence, 100% of the articles analysed in this study support the statement that Col can be used for gingival healing [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. However, 13% of the researchers emphasise that Col has less potential for GR healing compared with SCTG [ 14 , 18 ].…”

Section: Discussionsupporting

confidence: 71%

“…The thickness level for subjects treated with Col-based scaffold exhibits positive outcomes compared with the control group (no scaffold). Furthermore, rapid gingival tissue formation was observed for Col scaffold at pH 7.4 compared to pH 3.0 [ 13 ]. The result indicates that the optimum pH for Col scaffold greatly influences the rate of healing.…”

Section: Resultsmentioning

confidence: 99%

“…In the context of the functionality of Col scaffold, it has been scientifically proven by Hatayama et al that pH 7.4 is an ideal pH for optimum functionality for periodontal application [ 13 ]. This statement was supported by Ahmadi et al as the group demonstrated that, in acidic conditions, the necrotic effect is seen in the periodontal tissue and flaps of the mucosa, thereby hindering the normal healing mechanism in the oral tissue [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

“…In order to accommodate this problem from worsening, recent advancement in biomaterials is considerable as it has high biocompatible properties to human nature. Many studies have used Col-based scaffolds to study its effects in gingival healing using in vitro models [ 11 , 12 ], in vivo models [ 13 , 14 , 15 , 16 ], and clinical trials [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

2020

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Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.

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Section: Discussionsupporting

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

2020

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“…A spectrum of scaffold materials has been used to carry these stem cells and regenerative molecules including growth factors to the intended site of regeneration. Scaffold guided delivery of regenerative material has allowed a controlled system of tissue regeneration 4 . Tissue Engineering is a field of novel science and technology which brings medicine, engineering, and material science together for the regeneration and repair of lost and damaged tissues and the present poster summarizes the same.…”

mentioning

confidence: 99%