Regional arm-brain mean transit time in the diagnostic evaluation of patients with cerebral vascular disease.

Bartolini, A.

doi:10.1161/01.str.12.2.241

Cited by 17 publications

(5 citation statements)

References 17 publications

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“…Prolonged circulation times with increasing age would be expected from the well-known decrease in cerebral blood flow in older individuals [7]. AHT again compares well to earlier studies: Bartolini [31]reports mean values of 19.07 ± 3.4 s for the interval between injection of a radionuclide into a brachial vein and its detection by brain scintigraphy. Taking AHT and CCT together, the corresponding value in our study is 20.5 s.…”

Section: Discussionsupporting

confidence: 80%

Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Hoffmann

Weih²,

Schreiber³

et al. 2000

Cerebrovasc Dis

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We present a new, non-invasive ultrasound method for the measurement of cerebral circulation time. After injection of a galactose-based echo-contrast agent (Levovist) into an antecubital vein, cerebral circulation time is measured as the interval between the beginning of a stable signal enhancement of at least 5 dB in the internal carotid artery and in the ipsilateral internal jugular vein. Both vessels are insonated simultaneously at the mandibular angle using a single 2-MHz range-gated transducer. For this study, 25 healthy volunteers ranging in age from 23 to 55 years (30.1 ± 7.5 years; mean ± SD) were examined. Cerebral circulation time was 5.6 ± 1.7 s without significant side-to-side or sex-related differences. Measurement of circulation times offers a new possibility for the employment of echo-contrast agents in functional ultrasound.

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Section: Discussionsupporting

confidence: 80%

Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Hoffmann

Weih²,

Schreiber³

et al. 2000

Cerebrovasc Dis

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“…[ 16 ] The X-ray imaging equipment can be used to measure hemodynamic function [ 17 ] and cerebral circulation time (CCT) [ 18 – 22 ], besides visualizing the morphology [ 23 – 24 ]. DSA and intravenous radionuclide angiography with non-diffusible tracers [ 17 , 25 ] improved brain scan detection of CCT in normal and pathological conditions. In our study, we obtained velocity estimation from 2D sequence with modern DSA equipment and calculated CCT [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Cerebral Circulation Time is Prolonged and Not Correlated with EDSS in Multiple Sclerosis Patients: A Study Using Digital Subtracted Angiography

et al. 2015

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Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27s) and control group (mean = 2.8s; sd = 0.51s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.

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“…For several decades, it has been acknowledged that perfusion changes observed during SPECT seizures are closely related to the underlying electrophysiological changes observed during semiologically matched EEG seizures. [5][6][7][8]10,11,14 Based on the assumption that the nuclear tracer requires 15 to 20 seconds of transit time after intravenous injection to reach the brain, 15 the peak tracer uptake interval was defined as a time period of several seconds starting 15 seconds after the patient's individual SPECT injection. 14 Therefore, the ictal hyperperfusion pattern might reflect an average of the distribution of blood flow around peak time rather than just a snapshot at the moment the blood flow reaches the corresponding brain regions.…”

Section: Discussionmentioning

confidence: 99%

Regional Ictal Hyperperfusion in the Contralateral Occipital Area May Be a Poor Prognostic Marker of Anterior Temporal Lobectomy: A SISCOM Analysis of MTLE Cases

Hwang¹,

Lee²,

Jo³

et al. 2021

NDT

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Background and Objective: Subtraction of ictal SPECT coregistered to MRI (SISCOM) provides complementary information for detecting the ictal onset zone, especially in patients with MRI-negative focal epilepsy, and provides additional useful information for predicting long-term postresection outcomes. This study sought to investigate the relationship between surgical failure and increased cerebral blood flow (CBF) pattern using SPECT in patients with mesial temporal lobe epilepsy with unilateral hippocampal sclerosis (MTLE-HS). Methods: Among 42 subjects who underwent anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) for MTLE-HS, 29 (69.0%) were seizure-free (SF group). Hyperperfusion was compared in 14 ipsilateral and contralateral brain regions in SISCOM images between the two groups. Results: The pattern of ictal hyperperfusion in temporal regions did not vary significantly between the SF and non-seizure-free (NSF) groups. However, CBF increases in the contralateral occipital area was more frequent in the NSF group than in the SF group. Furthermore, ictal hyperperfusion of the ipsilateral occipital and contralateral parietal areas tended to be more frequent in the NSF group. Conclusion:The results indicate that poor ATL-AH surgical outcome is associated with a tendency of ictal hyperperfusion of the contralateral occipital cortex based on SISCOM analysis. The pattern of early ictal CBF changes implicating the propagation from temporal to occipital cortices can be considered a marker of poor surgical outcomes of ATL-AH in MTLE-HS patients.

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Regional arm-brain mean transit time in the diagnostic evaluation of patients with cerebral vascular disease.

Cited by 17 publications

References 17 publications

Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Measurement of Cerebral Circulation Time by Contrast-Enhanced Doppler Sonography

Cerebral Circulation Time is Prolonged and Not Correlated with EDSS in Multiple Sclerosis Patients: A Study Using Digital Subtracted Angiography

Regional Ictal Hyperperfusion in the Contralateral Occipital Area May Be a Poor Prognostic Marker of Anterior Temporal Lobectomy: A SISCOM Analysis of MTLE Cases

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