Regional monitoring of the urinary tract infections causative agents antibiotic resistance in the child population of the Chernivtsi region

Безрук, В. В.; Безрук, Т. O.; Stegnitska, L. V.; Sokolnyk, S. O.; Maksymyuk, V. V.; Godovanets, О. S.; Kovtun, A. I.; Шеремет, М. І.

doi:10.14739/2310-1210.2017.6.115088

Cited by 4 publications

(2 citation statements)

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“…Аналіз результатів етапів моніторингу і їх порівняння свідчать, що домінуючими уропатогенами серед дитячого населення в регіоні є представники родини Enterobacteriaceae. Серед штамів родини Enterobacteriaceae (за винятком протея) найбільш суттєвою виявилась різниця в чутливості до напівсинтетичних пеніцилінів (ампіцилін, амоксиклав -29,8 % чутливості штамів у хлопчиків проти 31,6 % чутливості у дівчат, р < 0,01) і цефалоспоринів (цефазолін -64,4 % проти 40,1 % відповідно, р < 0,001) [3][4][5].…”

Section: результати та обговоренняunclassified

“…Антибіотикочутливість бактерій роду протей, що є збудниками ІСШ, має певні особливості: у сечі дівчат визначено вірогідно нижчий відсоток резистентних штамів протею порівняно з іншими ентеробактеріями до карбеніциліну (k = 259, р < 0,05); амоксиклаву (k = 131, р < 0,05); офлоксацину (k = 378, р < 0,01); ципрофлоксацину (k = 390, р < 0,01); у хлопців встановлено статистично значущу різницю чутливості між бактеріями роду протей та іншими ентеробактеріями для карбеніциліну (k = 105, р < 0,001); цефоперазону (k = 100, р < 0,001); цефтріаксону (k = 145, р < 0,001); офлоксацину (k = 134, р < 0,05); ципрофлоксацину (k = 145, р < 0,05); пефлоксацину (k = 103, р < 0,05); канаміцину (k = 102, р < 0,01) [3][4][5].…”

Section: результати та обговоренняunclassified

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Monitoring and features of antibiotic resistance during the COVID-19 pandemic

Безрук

Ivanov

Shkrobanets

2023

KIDNEYS

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Background. Urinary tract infection (UTI) is an urgent problem in nephrology. The current state of antibiotic resistance to antimicrobial drugs complicates the empirical choice of antibacterial therapy, and indications for the use of antimicrobial drugs are not always clinically justified. The purpose of the study: to compare the antibiotic resistance of the main groups of UTI pathogens during coronavirus 2019 (COVID-19) pandemic in 2020–2022 with the results of 2014–2016 monitoring among children of the Chernivtsi region. Materials and methods. Urine samples were collected from 657 children (0–17 years old) who received specialized medical care in health care institutions of the Chernivtsi region (2014–2016). During 2020–2022, a clinical and laboratory examination of 180 children (0–17 years old) was conducted. Results. The results of the monitoring proved the wave-like nature of changes in antibiotic resistance to semi-synthetic penicillins and cephalosporins with the maintenance of a sufficient level of sensitivity to these antimicrobial drugs among the main groups of UTI pathogens; the data obtained give reason to suggest a negative trend to increasing resistance to fluoroquinolones, tetracyclines over time (2020–2022 — the period of the COVID-19 pandemic); a multidirectional and time-dependent differences were revealed in sensitivity to aminoglycosides: gentamicin, amikacin and kanamycin in children of Chernivtsi region, as well as a negative trend to increasing the share of carbapenem-resistant strains of uropathogens — 55.8 ± 5.1 % (imipenem — χ2 = 5.432; p = 0.020). Conclusions. The monitoring results indicate the need to comply with standards in the provision of medical care (prescribing antibacterial therapy taking into account the data of regional monitoring on antibiotic resistance to antimicrobial drugs), administration of antimicrobial drugs in health care institutions that provide medical care in outpatient and inpatient settings. High level of antibiotic resistance of UTI uropathogens to carbapenems (2020–2022), used for the treatment of severe bacterial infections, requires their exclusively targeted prescription in everyday pediatric practice.

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Section: результати та обговоренняunclassified

Monitoring and features of antibiotic resistance during the COVID-19 pandemic

Безрук

Ivanov

Shkrobanets

2023

KIDNEYS

View full text Add to dashboard Cite

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Medical management: a model for giving medical aid to children with infectious-inflammatory diseases of the urinary system

et al. 2021

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Increasing requirements of medical aid given to children with infectious-inflammatory diseases of the urinary system stipulate the necessity to improve its quality using evidence-based therapeutic-diagnostic and organization technologies. The aim of the work – to substantiate, develop the improved model of the specialized nephrology care for children with infectious inflammatory diseases of the urinary system at the regional level. The official statistical data have been studied (2006 to 2017); information-analytical and statistical methods have been used. A bacteriological study (2009–2016) of urine samples was carried out for 3089 children (0–17 years old) in the Chernivtsi region. They formed the foundation for substantiation and development of an improved functional-organizational model of the system. In addition to the existing and functionally changed elements contains new elements: regional/inter-regional center of specialized medical aid to children with infectious-inflammatory diseases of the urinary system. Implementation of the elements of the suggested improved model in a part of a rational approach in distribution of functions concerning medical observation of patients at the stages of giving medical aid enabled to make the period of hospitalization of nephrological patients 11,40% shorter and an average period of treatment of patients with infectious-inflammatory diseases of the urinary system 2,93% shorter.

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Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic

et al. 2022

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Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009–2016 with intermediate results from 2020–2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0–17 years old) treated at the health care institutions in the Chernivtsi region (2009–2016). The clinical-laboratory examination of 177 children (0–17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020–2021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01) and imipenem – χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem – χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020–2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.

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Regional monitoring of the urinary tract infections causative agents antibiotic resistance in the child population of the Chernivtsi region

Cited by 4 publications

References 2 publications

Monitoring and features of antibiotic resistance during the COVID-19 pandemic

Monitoring and features of antibiotic resistance during the COVID-19 pandemic

Medical management: a model for giving medical aid to children with infectious-inflammatory diseases of the urinary system

Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic

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