2021
DOI: 10.3390/antiox10121862
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Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina

Abstract: The eye is continuously under oxidative stress due to high metabolic activity and reactive oxygen species generated by daily light exposure. The redox-sensitive protein DJ-1 has proven to be essential in order to protect retina and retinal pigment epithelium (RPE) from oxidative-stress-induced degeneration. Here, we analyzed the specific role of Müller cell DJ-1 in the adult zebrafish retina by re-establishing Müller-cell-specific DJ-1 expression in a DJ-1 knockout retina. Loss of DJ-1 resulted in an age-depen… Show more

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Cited by 6 publications
(4 citation statements)
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“…Dysregulation of ER stress response affect mitochondrial dynamics [ 59 ]. Interestingly, knockout of the ER transmembrane protein Wfs1 results in a number of similar dysfunctions as we observe in the DJ-1 KO including retina thinning, loss of retinal ganglion cells, growth retardation, increased anxiety and movement defects [ 60 , 61 , 62 ]. Wfs1 acts upstream and DJ-1 downstream of PINK/Parkin [ 59 , 63 ], thus their signaling pathways converge and may be reflected in their deficiency-induced phenotypes.…”
Section: Resultsmentioning
confidence: 60%
“…Dysregulation of ER stress response affect mitochondrial dynamics [ 59 ]. Interestingly, knockout of the ER transmembrane protein Wfs1 results in a number of similar dysfunctions as we observe in the DJ-1 KO including retina thinning, loss of retinal ganglion cells, growth retardation, increased anxiety and movement defects [ 60 , 61 , 62 ]. Wfs1 acts upstream and DJ-1 downstream of PINK/Parkin [ 59 , 63 ], thus their signaling pathways converge and may be reflected in their deficiency-induced phenotypes.…”
Section: Resultsmentioning
confidence: 60%
“…Programs that utilize peak alignment algorithms, ascertain measurements for a given peptide in runs where the peptide is not identified at the MS/MS level by leveraging information from other runs, and the development of novel intensity determination and normalization procedures (Cox et al, 2014; May et al, 2008) collectively raised the confidence of researchers in label‐free quantifications based on MS peak area measurements. The availability of the method in commercial (e.g., Progenesis LC‐MS and QI, Proteome Discoverer and Mascot), and in open‐source (MaxQant, https://www.maxquant.org; Tyanova et al, 2016) software packages also has contributed to the widespread application of the technique to retina proteomics (Cehofski et al, 2015; Eastlake et al, 2018; Gharbi et al, 2021; Grotegut et al, 2020; Hauck et al, 2010; B. Liu et al, 2020; Ly et al, 2014; Perumal et al, 2020; Ruzafa et al, 2018; Suo et al, 2022; Tu et al, 2015; Zhu et al, 2017—just to mention a few of these studies).…”
Section: Ms‐based Proteomics To Catalog and Measure Protein Expressio...mentioning
confidence: 99%
“…The availability of the method in commercial (e.g., Progenesis LC-MS and QI, Proteome Discoverer and Mascot), and in open-source (MaxQant, https://www. maxquant.org; Tyanova et al, 2016) software packages also has contributed to the widespread application of the technique to retina proteomics (Cehofski et al, 2015;Eastlake et al, 2018;Gharbi et al, 2021;Grotegut et al, 2020;Hauck et al, 2010;B. Liu et al, 2020;Ly et al, 2014;Perumal et al, 2020;Ruzafa et al, 2018;Suo et al, 2022;Tu et al, 2015;Zhu et al, 2017-just to mention a few of these studies).…”
Section: Ms-based Proteomics To Catalog and Measure Protein Expressio...mentioning
confidence: 99%
“…Novel pathogenic mechanisms and therapeutic approaches for eye disorders were described here, holding hope for the development of new treatments for optic neuropathies, based on intravitreal injections of pegylated granulocyte colony-stimulating factor (G-CSF) [ 14 ], and for AMD patients carrying Y402H polymorphism in the factor H protein (FH), based on the mTOR inhibition [ 15 ]. Moreover, it was demonstrated here that the redox-sensitive protein DJ-1 is required to protect the retina and retinal pigment epithelium (RPE) from oxidative-stress-induced degeneration [ 16 ]. This Special Issue also gathered studies focused on the identification of new biomarkers for AD preclinical diagnosis [ 17 ], of new treatments based on the administration of hydroxocobalamin (Hb, vitamin B 12 analog) to prevent cytoplasmic aggregation of TDP-43 observed in many neurodegenerative diseases [ 18 ], of a new mechanism linking astrocyte-derived oxidative stress to motor-neuron damage in ALS [ 19 ], and on the role of the alpha–ketoglutarate dehydrogenase complex (KGDHC), a rate-limiting enzyme in the tricarboxylic acid cycle, whose activity is strikingly reduced in AD [ 16 ], in the bioenergetics and reactive oxygen species (ROS) homeostasis of brain mitochondria [ 20 ].…”
mentioning
confidence: 99%