Relation between Serum Intact Parathyroid Hormone Level and Hematocrit in Chronic Kidney Disease Patients

Adhikary, Laxman P.; Pokhrel, Anusheela; Yadava, Sanjay; Khadka, Dipendra; Thakur, R

doi:10.3126/kumj.v13i3.16811

Cited by 8 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this context, Goel et al (27) reported that the level of intact PTH in 174 CKD patients on hemodialysis was 440.9 ± 397.8 pg/ml. Adhikary et al (28) also reported that intact PTH level in 80 CKD participants having an indication of hemodialysis was 458.12 ± 101.27 pg/ml. In addition, Gallieni et al (16) found a significant elevation (p<0.001) in serum PTH levels in stage 5 CKD patients at the end of their study when compared with baseline values.…”

Section: Discussionmentioning

confidence: 94%

Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients

Radeef

2020

Baghdad Sci.J

View full text Add to dashboard Cite

This study designed to examine association between-174G/C polymorphism of interleukin-6 gene and phosphate, calcium, vitamin D3, and parathyroid hormone levels in Iraqi patient with chronic kidney disease on maintenance hemodialysis. Seventy chronic renal failure patients (patients group) and 20 healthy subjects (control group) were genotyped for interleukin-6 polymorphism and genotyping was performed by conventional polymerase chain reaction-restriction fragment length polymorphism. No significant differences in phosphate levels were observed in patients and control with different interleukin-6 genotypes. Control had non-significant differences in calcium levels, while patients with GG and CG genotypes displayed significant elevation with time. Conversely, control and patients with GG and CC genotypes had significant elevation in vitamin D3 levels with time. Regarding parathyroid hormone, control had non-significant differences, while patients with GG and CC genotypes displayed significant elevation with time. Patients with GG genotype displayed significant changes in calcium, vitamin D3 and parathyroid hormone levels with time.

show abstract

Section: Discussionmentioning

confidence: 94%

Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients

Radeef

2020

Baghdad Sci.J

View full text Add to dashboard Cite

show abstract

“…8 In the study of Adhikary et al, which included chronic renal patients aged between (29:70) years, it indicated an inverse relationship between normal hematocrit and parathyroid levels, which is the same results revealed by our current research. 9 More recently, Azeem et al evaluated 110 Patients undergoing maintenance hemodialysis with PTH levels greater than 300 ng/L. The authors concluded that patients with hyperparathyroidism frequently develops anemia.…”

Section: Discussionmentioning

confidence: 99%

Relationship between anemia and biochemical parameters of mineral bone disorders in chronic kidney disease patients

Sayed

Ismail²,

Saad³

et al. 2022

Al-Azhar International Medical Journal

View full text Add to dashboard Cite

Background: Anemia, electrolyte disturbances and mineral bone disorders are common outcomes of chronic kidney disease (CKD). Aim of the work: To asses' relationship between anemia and mineral bone disorder (MBD) parameters in stages 3-5 CKD on conservative treatment patients. Patients and Methods:The current study included a sample of ( 160) cases, all of whom had chronic kidney disease All subjects were submitted to full history, clinical examination, and laboratory testing which included complete blood count, Calcium, Phosphorus and Parathyroid hormone (PTH). Quantitative determination of total 25-OH Vitamin D was measured in all patients. Estimated glomerular filtration rate (eGFR) was being calculated. Result:The study revealed a statistically significant association between Hb and eGFR, and also showed a statistically significant negative relationship (p value = 0.001) (r = -0.38) between Hb and serum creatinine. It also revealed a semi-inverse relationship between serum parathormone (iPTH) and hemoglobin level in blood between CKD. Whenever there is an increase in the serum iPTH reflects the decrease in the level of hemoglobin in the blood of the study sample of patients with chronic kidney disease. One of the important statistical results indicated by the study is that blood phosphate is linked to low hemoglobin in kidney patients. Our study agreed with studies that show that vitamin D deficiency is closely related to low hemoglobin level in CKD patients.The lower the calcium level, the lower the hemoglobin level. We found that increased blood calcium is associated with a higher hemoglobin level. Conclusion:Our study showed the significant association between CKD-BMD and anemia. It also showed that increased serum phosphate, parathyroid activity, severe deficiency in vitamin D and a high incidence of anemia among patients with chronic kidney disease.

show abstract

“…A anemia é um achado comum nos pacientes renais crônicos, surgindo precocemente no curso da DRC 17 . Assim como neste estudo, encontrou-se uma relação inversa entre os valores de hematócrito e de PTH, sugerindo esta situação como uma possível explicação para os casos de anemia mesmo em tratamento com eritropoietina recombinante (EPO) 18 .…”

Section: Discussionunclassified

[Id 47385] Perfil Clínico E Bioquímico De Pacientes Em Hemodiálise Com Hiperparatireoidismo Secundário

Silva

Rodrigues²,

Dias

et al. 2020

RBCS

View full text Add to dashboard Cite

Objetivo: Avaliar o perfil clínico e bioquímico de pacientes com e sem HPTS. Metodologia: Estudo transversal e analítico realizado com 93 pacientes com DRC em HD. Os pacientes foram alocados em dois grupos: sem HPTS (Paratormônio: < 300pg/mL) e com HPTS (Paratormônio: ≥ 300pg/mL). Foram verificados os dados socioeconômicos por meio de questionário semiestruturado. Os dados bioquímicos e antropométricos foram obtidos por meio do prontuário de cada paciente. Também foram coletadas informações quanto ao tempo de HD, tabagismo, diabetes mellitus, hipertensão arterial sistêmica, cardiopatias, atividade física e a razão triglicerídeo/HDL-Colesterol. Resultados: O gênero feminino apresentou-se prevalente no grupo com HPTS (59,09%, p=0,017). Nos pacientes que não apresentavam HPTS foi detectado maior presença de diabetes mellitus (77,27%, p=0,021). Os pacientes com HPTS diferiram dos pacientes sem HPTS para o hematócrito (p=0,0457), creatinina (p=0,0303) e a fosfatase alcalina (p=0,0011). Conclusão: Encontramos diferença ao comparar os grupos quanto aos níveis de hematócrito, creatinina, fósforo e fosfatase alcalina, resultados que podem implicar no estado clínico de indivíduos com HPTS. Essas análises poderão direcionar condutas e estratégias específicas para o acompanhamento da doença e proposta adequada de tratamento, buscando a melhora do quadro clínico e qualidade de vida. DESCRITORES: Hiperparatireoidismo Secundário. Insuficiência Renal Crônica. Diálise Renal.

show abstract

Relation between Serum Intact Parathyroid Hormone Level and Hematocrit in Chronic Kidney Disease Patients

Cited by 8 publications

References 20 publications

Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients

Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients

Relationship between anemia and biochemical parameters of mineral bone disorders in chronic kidney disease patients

[Id 47385] Perfil Clínico E Bioquímico De Pacientes Em Hemodiálise Com Hiperparatireoidismo Secundário

Contact Info

Product

Resources

About