Relationship between Blood and Induced Sputum Eosinophils, Bronchial Hyperresponsiveness and Reversibility of Airway Obstruction in Mild-to-Moderate Chronic Obstructive Pulmonary Disease

Proboszcz, Małgorzata; Mycroft, Katarzyna; Paplińska-Goryca, Magdalena; Górska, Katarzyna; Nejman-Gryz, Patrycja; Jankowski, Piotr; Zak, Natalia; Krenke, Rafał

doi:10.1080/15412555.2019.1675150

Cited by 18 publications

(18 citation statements)

References 32 publications

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“…However, it was found that peripheral eosinophil counts did not accurately predict sputum eosinophil counts, especially in patients with mild-to-moderate COPD [23]. In steroid-naïve patients with mild-to-moderate COPD, no relationship between the peripheral eosinophil count and the sputum eosinophil percentage was found, highlighting the importance of assessing the level of eosinophils in the airways [6]. Our study focused on the relationship between local eosinophilic airway in ammation and lung function.…”

Section: Discussionmentioning

confidence: 89%

“…COPD patients with high levels of blood eosinophils have been found to be more sensitive to treatment with ICS, and there was an increase in the number of exacerbations in these patients when ICS therapy was discontinued [26]. Across studies, the incidence of high blood eosinophil levels varies signi cantly, ranging from 14-37% of COPD patients, while high levels of sputum eosinophils were detected in 30%~40% of COPD patients, suggesting that sputum eosinophils may an effective and more stable predictor of the response to ICS therapy in COPD patients [6,27]. It is important for clinical trials targeting eosinophilic in ammation in COPD to consider the assessment of sputum eosinophils.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal in ammatory responses in the lungs are usually caused by noxious particles or gases, leading to the progressive destruction of the structure and function of the lungs [5]. In ammatory cells, such as neutrophils and eosinophils accumulate in airways, inducing the production and activation of a variety of in ammatory cytokines and proteases that participate in the chronic in ammation that is characteristic of COPD [5][6][7]. Previous studies have shown that tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and leukotriene B4 (LTB4) are crucial cytokines involved in the airway in ammatory response [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the dysregulation of microRNAs (miRNAs), such as microRNA-155 (miR-155) and microRNA-21 (miR-21), was shown to be involved in the in ammatory response or brosis in pulmonary diseases [14]. Systemic in ammation markers can be assessed in the peripheral blood in COPD patients; however, this method does not seem to be a su ciently accurate method of re ecting the in ammatory processes within the airways [6,15]. Thus, a reliable measurement of local airway in ammation in COPD should be based on samples obtained from the location of sustained in ammation.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity

He¹,

Deng²,

Jia³

et al. 2020

Preprint

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Background: The progression of an abnormal inflammatory response plays a crucial role in the functional decline that occurs in COPD patients[1].Compared to serum biomarkers, inflammatory biomarkers in induced sputum would be a more reliable reflection of the inflammatory processes in the airways. Based on this, we explored the association of inflammatory biomarkers in induced sputum with lung function in COPD patients.Methods: 102 patients with COPD were recruited and underwent spirometry. According to the percentage of the predicted forced expiratory volume in 1 second value (FEV1%pred), participants with COPD were divided into a mild and moderate group (FEV1%pred≥ 50%, n=57) and a severe and extremely severe group (FEV1%pred<50%, n=45). Then we analyzed a series of inflammatory biomarkers in induced sputum and determined their association with lung function in COPD patients.Results: We found an increased levels of eosinophils percentage, MMP9 mRNA, LTB4R mRNA, and decreased levels of CC16 mRNA and miR-155 in the induced sputum of patients with severe and extremely severe COPD. In our analysis, sputum cell CC16 mRNA expression, but not CC16 secretion in the supernatant of the sputum, was closely and independently correlated with lung function decline in patients with COPD. Conclusion: The levels of numerous inflammatory biomarkers in induced sputum were associated with lung function decline in COPD，and the relative CC16 mRNA expression level with a cutoff of 1.09 could be a predictive biomarker of the severity of COPD.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity

He¹,

Deng²,

Jia³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In stable mild-to-moderate COPD, no such correlation was observed, while in moderate-to-severe disease a weak correlation was found, and peripheral eosinophils could not predict sputum eosinophilia. 24 , 27 , 29 , 30 Despite these rather poor correlations in stable COPD, blood eosinophil counts have been proposed as a marker to guide ICS treatment. 1 The eosinophilic pattern in COPD patients results either from co-existing asthma or poorly understood mechanisms that may lead to airway eosinophilia in COPD patients without any asthmatic features.…”

Section: Discussionmentioning

confidence: 99%

Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD

Celejewska‐Wójcik¹,

Kania²,

Górka³

et al. 2021

COPD

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Purpose: Lipid mediators, particularly eicosanoids, are associated with airway inflammation, especially with the eosinophilic influx. This study aimed to measure lipid mediators and cells in induced sputum, that could possibly reflect the inflammatory process in the bronchial tree of COPD subjects. Patients and Methods: Eighty patients diagnosed with COPD and 37 healthy controls participated in the study. Induced sputum samples were ascertained for differential cell count and induced sputum supernatant concentrations of selected eicosanoids by the means of gas chromatography/mass spectrometry and high-performance liquid chromatography/tandem mass spectrometry. Results: Increased sputum eosinophilia was associated with higher concentrations of selected proinflammatory eicosanoids. In COPD subjects prostaglandin D 2 and 11-dehydro-thromboxane B 2 correlated negatively with airway obstruction measured by FEV 1 and FEV 1 /FVC values. COPD subjects with disease exacerbations during past 12 months had significantly higher concentrations of prostaglandin D 2 , 12-oxo-eicosatetraenoic acid and 5oxo-eicosatetraenoic acid. Conclusion:Stable COPD is often associated with eosinophil influx in the lower airways and elevated concentrations of eicosanoids that is reflected by some disease characteristics.

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Benefits and Risks of Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease Classified by Blood Eosinophil Counts

Saito¹,

Yoshida²,

Kojima³

et al. 2020

Lung

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Relationship between Blood and Induced Sputum Eosinophils, Bronchial Hyperresponsiveness and Reversibility of Airway Obstruction in Mild-to-Moderate Chronic Obstructive Pulmonary Disease

Cited by 18 publications

References 32 publications

Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity

Inflammatory Biomarkers in induced Sputum Predict Chronic Obstructive Pulmonary Disease (COPD) Severity

Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD

Benefits and Risks of Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease Classified by Blood Eosinophil Counts

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