Relationship between bone mineral density and dietary intake of β-carotene, vitamin C, zinc and vegetables in postmenopausal Korean women: a cross-sectional study

Kim, Da Eun; Cho, Soo Hyun; Park, Hyoung Moo; Chang, Yu Kyung

doi:10.1177/0300060516662402

Cited by 45 publications

(48 citation statements)

References 33 publications

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“…Previous studies on the relationship between β-carotene intake and fracture risk reported controversial results. Several population-based studies demonstrated protective effect of β-carotene on bone [ 52 , 53 ]. However, Wolf et al [ 54 ] and Melhus et al [ 55 ] have shown a negative influence of β-carotene on bone.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

Zhang

Moore

et al. 2017

IJERPH

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This meta-analysis evaluated the influence of dietary intake and blood level of vitamin A (total vitamin A, retinol or β-carotene) on total and hip fracture risk. Cohort studies published before July 2017 were selected through English-language literature searches in several databases. Relative risk (RR) with corresponding 95% confidence interval (CI) was used to evaluate the risk. Heterogeneity was checked by Chi-square and I2 test. Sensitivity analysis and publication bias were also performed. For the association between retinol intake and total fracture risk, we performed subgroup analysis by sex, region, case ascertainment, education level, age at menopause and vitamin D intake. R software was used to complete all statistical analyses. A total of 319,077 participants over the age of 20 years were included. Higher dietary intake of retinol and total vitamin A may slightly decrease total fracture risk (RR with 95% CI: 0.95 (0.91, 1.00) and 0.94 (0.88, 0.99), respectively), and increase hip fracture risk (RR with 95% CI: 1.40 (1.02, 1.91) and 1.29 (1.06, 1.57), respectively). Lower blood level of retinol may slightly increase total fracture risk (RR with 95% CI: 1.11 (0.94, 1.30)) and hip fracture risk (RR with 95% CI: 1.27 (1.05, 1.53)). In addition, higher β-carotene intake was weakly associated with the increased risk of total fracture (RR with 95% CI: 1.07 (0.97, 1.17)). Our data suggest that vitamin A intake and level may differentially influence the risks of total and hip fractures. Clinical trials are warranted to confirm these results and assess the clinical applicability.

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Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

Zhang

Moore

et al. 2017

IJERPH

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“…Out of twentyfour studies that were included in the systematic review, we excluded twenty studies because of the following reasons: those that reported results as beta regression (20) Cohort coefficient (24,25,(27)(28)(29)31,38,42,50,51,54,58,59,61) ; those that reported BMD's means and standard deviations in categories of vitamin C intake (55) or users vitamin C supplement v. non-users (52) ; those that reported relative risks (RR) and 95 % CI in tertiles of vitamin C intake (57) ; and those that measured BMD at calcaneus (56) , total forearm, trabecular forearm, cortical forearm (53) and whole body (30) . Finally, four studies (23,26,34,60) that examined the correlation between dietary vitamin C intake and BMD at femoral neck (four effect sizes obtained from four studies) and lumbar spine (three effect sizes obtained from three studies) were included in the meta-analysis. Studies that reported correlation coefficient between dietary vitamin C intake and BMD included 3529 individuals in total.…”

Section: Findings Of the Meta-analysismentioning

confidence: 99%

Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies

2018

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We aimed to systematically review available data on the association between vitamin C intake and bone mineral density (BMD), as well as risk of fractures and osteoporosis, and to summarise this information through a meta-analysis. Previous studies on vitamin C intake in relation to BMD and risk of fracture and osteoporosis were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases before February 2017, using MeSH and text words. To pool data, either a fixed-effects model or a random-effects model was used, and for assessing heterogeneity, Cochran's Q and I 2 tests were used. Subgroup analysis was applied to define possible sources of heterogeneity. Greater dietary vitamin C intake was positively associated with BMD at femoral neck (pooled r 0·18; 0·06, 0·30) and lumbar spine (pooled r 0·14; 95 % CI 0·06, 0·22); however, significant between-study heterogeneity was found at femoral neck: I 2=87·6 %, P heterogeneity<0·001. In addition, we found a non-significant association between dietary vitamin C intake and the risk of hip fracture (overall relative risk=0·74; 95 % CI 0·51, 1·08). Significant between-study heterogeneity was found (I 2=79·1 %, P heterogeneity<0·001), and subgroup analysis indicated that study design, sex and age were the main sources of heterogeneity. Greater dietary vitamin C intake was associated with a 33 % lower risk of osteoporosis (overall relative risk=0·67; 95 % CI 0·47, 0·94). Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosis, as well as higher BMD, at femoral neck and lumbar spine.

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“…Previous human studies on the association between carotenoid intake and bone health have been performed in Western countries, including America [ 21 ], Australia [ 27 ], and Japan [ 28 ]. To the best of our knowledge, only one study has examined the association between dietary carotenoid intake and bone health in Korea [ 29 ]. That study reported a positive association between β-carotene intake and BMD in Korean postmenopausal women aged 50–75 years [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, only one study has examined the association between dietary carotenoid intake and bone health in Korea [ 29 ]. That study reported a positive association between β-carotene intake and BMD in Korean postmenopausal women aged 50–75 years [ 29 ]. However, that study was conducted with a small sample size ( n = 189) and a convenience sampling method.…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Carotenoid Intake and Bone Mineral Density in Korean Adults Aged 30–75 Years Using Data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (2008–2011)

Regu

Kim

et al. 2017

Nutrients

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Age-related bone loss is a major public health problem. This cross-sectional study examined the association between the dietary intake of carotenoids and bone mineral density (BMD). Data from 8022 subjects (3763 males and 4259 females) aged 30–75 years included in the Korean National Health and Nutrition Examination Survey (2008–2011) were analyzed. BMD was measured by dual-energy X-ray absorptiometry. Intake of carotenoids was estimated using 24-h dietary recall. In multiple linear analysis, after adjusting for covariates, lutein + zeaxanthin and β-cryptoxanthin intake was positively associated with total hip BMD in males and premenopausal women respectively, while β-carotene intake was positively correlated with femoral neck, total hip, and whole-body BMD in postmenopausal women. Postmenopausal women in the highest quintile of daily β-carotene intake, showed a lower risk of osteopenia at the lumbar spine (odds ratio (OR): 0.35, 95% CI: 0.16–0.79, P for trend = 0.009) than those in the lowest quintile, after adjusting for covariates. Daily β-cryptoxanthin intake was significantly associated with a lower risk of osteopenia at the total hip (OR per 1 mg/day increase: 0.76; 95% CI: 0.59–0.97), and lumbar spine (OR per 1 mg/day increase: 0.79; 95% CI: 0.70–0.89) in postmenopausal women. These results suggest that the dietary intake of β-carotene and β-cryptoxanthin may have a positive effect on bone health.

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Relationship between bone mineral density and dietary intake of β-carotene, vitamin C, zinc and vegetables in postmenopausal Korean women: a cross-sectional study

Cited by 45 publications

References 33 publications

The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies

Association between Dietary Carotenoid Intake and Bone Mineral Density in Korean Adults Aged 30–75 Years Using Data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (2008–2011)

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