Relationship Between Glycoprotein IIIa Platelet Receptor Gene Polymorphism and Coronary Artery Disease

Abstract

Glycoprotein IIb/IIIa (GP IIb/IIIa) is a key receptor for platelet aggregation and adhesion. We investigated whether a single-nucleotide polymorphism of GP IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele) is associated with the extent of coronary artery disease (CAD) in a consecutive cohort of 1518 patients undergoing coronary angiography. Significant CAD was defined as at least a stenosis >50% and severe CAD as left main disease and/or trivessel disease. Additionally, carotid intima-media thickness (cIMT) was evaluated in 339 patients. The PlA(2) allele was observed in 458 (30.2%) patients and associated with hypercholesterolemia (P = .03). No difference was observed in the prevalence of CAD (72.6% vs 70.1%, P = .29; adjusted odds ratio, OR [95% confidence interval, CI] = 0.85 [0.67-1.08], P = .19) and severe CAD (27.5% vs 26.5%, adjusted OR [95% CI] = 0.93 [0.72-1.19], P = .55). Furthermore, Leu33Pro polymorphism did not affect cIMT and the prevalence of carotid plaques. Therefore, this polymorphism cannot be regarded as a risk factor for coronary or carotid atherosclerosis.

Genetic risk factors of atherothrombosis

“…68 In the Atherosclerosis Risk in Communities (ARIC) Study, Kucharska-Newton et al 69 observed that subjects with the Leu33Pro polymorphism have greater density of P-selectin in platelet surface, which would hence predispose to increased risk of atherosclerotic plaque rupture. However, Verdoia et al 70 excluded that this polymorphism is a risk factor for coronary or carotid atherosclerosis in a consecutive cohort of 1518 patients undergoing coronary angiography. The same group previously showed that the PLA(1)/PLA(2) polymorphism has no influence on response to GPIIb-IIIa inhibitors in patients undergoing coronary angioplasty.…”

The Inconclusive Results of the Studies on Glycoprotein IIIa Platelet Receptor Gene Polymorphism and Coronary Artery Disease

“…We read with great interest the article entitled “Relationship between glycoprotein IIIa platelet receptor gene polymorphism and coronary artery disease” by Verdoia et al 1 The authors 1 investigated whether a single-nucleotide polymorphism of IIIa subunit (Leu 33 platelet antigen 1 and 2 [PlA 1 /PlA 2 ]) is associated with the extent of coronary artery disease (CAD) and carotid atherosclerosis. The main finding of this study 1 is that the PlA 2 allele was not associated with the prevalence and extent of CAD and carotid atherosclerosis.…”

FGB, TNFα, IL-1β, LPL, ITGB3, and TGFB1 genes polymorphism in patients with recurrent myocardial infarction

“…Полиморфизм гена LPL в большинстве исследований не показал значимого влияния на частоту развития и особенности течения коронарного атеросклероза [8], однако предполагается его связь с неблагоприятным течением при целом ряде сопутствующих факторов. Полиморфизм PlA2 гена ITGB3 в большом количестве исследований ассоциируется с частотой развития острых состояний, в том числе у более молодых пациентов, однако практически не имеет значения для развития хронических состояний [9]. Наличие полиморфизма на участке гена IL1β −511C/T ассоциируется с частотой и степенью развития атеросклеротических стенозов различных локализаций, при этом данные о его влиянии на частоту развития ИМ довольно противоречивы [10].…”