Relationship between insulin resistance and end-organ damage in white coat hypertension

Tunçkale, Aydın; Aran, Sinan N.; Karpuz, Hakan; Dırıcan, Ahmet

doi:10.1016/j.amjhyper.2004.07.002

Cited by 9 publications

(10 citation statements)

References 37 publications

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“…Thus, we agree to previous studies that they indicate a possible relationship between end-organ damage and insulin resistance in patients with white coat hypertension exists [16, 17]. The association between white-coat hypertension and metabolic disturbances of insulin-resistance syndrome may help explain the high prevalence of cardiovascular disease often associated with white coat hypertension [18–20].…”

Section: Discussionsupporting

confidence: 92%

Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Marchi-Alves

Cárnio

2009

Cardiology Research and Practice

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We evaluated a relationship between nitric oxide plasma correlation and insulin resistance in white coat hypertensive patients. Patients were screened for white coat hypertension using an ambulatory blood pressure monitoring. The homeostasis model assessment insulin resistance index (HOMA-IR) was used to assess insulin resistance, and plasma nitrate concentrations were determined by chemiluminescence. The HOMA-IR was significantly higher in hypertensive (3.84 ± 0.62) when compared to white coat (2.11 ± 0.36) and normotensive (1.40 ± 0.21). We found no correlation between HOMA-IR and plasma nitrate levels in all three groups. We suggest that the more important issue for these patients is to focus on the metabolic abnormalities where lifestyle interventions such as weight control and exercise have proven effective.

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Section: Discussionsupporting

confidence: 92%

Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Marchi-Alves

Cárnio

2009

Cardiology Research and Practice

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“…20 Interestingly, in a recent study patients with WCH and LVH were more insulin-resistant than those without LVH. 29 Other potential biologic mediators of LV hypertrophy in subjects with MetS may be certain peptide hormones, such as angiotensin II and leptin, which are secreted by white adipose tissue. 20 Our findings also suggest that the clustering of features of MetS, frequently described in WCHs, may be at least in part responsible for the cardiac abnormalities, and probably for the increased cardiovascular risk displayed in some, but not all, series regarding subjects with WCH [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] .…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in subjects with white-coat hypertension: impact on left ventricular structure and function

et al. 2007

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Some reports have suggested that white-coat hypertension (WCH) is associated with some features of the metabolic syndrome (MetS). These metabolic disturbances, instead of WCH per se, may potentially explain the greater extent of end-organ damage sometimes observed in WCH subjects (WCHs) when compared to normotensive individuals (NTs). The aim of the present cross-sectional study was to compare left ventricular (LV) structure and function in three groups of subjects: WCHs with MetS, WCHs without MetS and NTs. A total of 145 WCHs, 35% of whom had MetS, were enrolled. As controls, 35 NTs were also studied. In all subjects, routine blood chemistry, echocardiographic examination and 24-h ambulatory blood pressure monitoring were performed. When compared with WCHs without MetS, those with MetS showed higher LV mass indexed by height elevated by a power of 2.7 (LVMH 2.7 ) (49.6714.8 vs 38.979.8 g/m 2.7 ; Po0.0001). The same parameter was greater in WCHs without MetS than in NTs (3278 g/m 2.7 ; P ¼ 0.004). Moreover, the E-wave deceleration time was longer in WCHs with MetS than in those without it (236.2766.4 vs 200.5730.8 ms; Po0.0001). The relationship of MetS with LVMH 2.7 was confirmed in multivariate regression models. Our results seem to suggest that MetS may have a deleterious influence on LV structure and function in WCH. However, WCH, being associated with an increased LV mass, also in subjects without MetS, may not be considered as an innocuous phenomenon.

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“…The formula HOMA-IR = fasting glucose (mmol/L) * fasting insulin (mU/L) / 22.5 has been applied for calculation purposes [13].…”

Section: Methodsmentioning

confidence: 99%

“…The BMI has been calculated by the weight (kg) / height² (m) formula [13]. Overweight has been determined as BMI ≥25-29.9 kg/m 2 and obesity as BMI ≥ 30 kg/m 2 [11].…”

Section: Subjectsmentioning

confidence: 99%

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

Özkaya¹,

Bavunoğlu²,

Tunçkale³

2014

AJPHR

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Study Design:Obesity prevalence is incresing in Turkish population whose lipoprotein profile is characterised by low levels of HDL cholesterol. Our study aims to determine how obesity changes lipid profiles in Turkish women. Materials and Methods: We evaluated 2501 overweight and obese adult women. After systemic physical examination and some antropometric studies, blood samples have been analysed for lipid parameters.

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Relationship between insulin resistance and end-organ damage in white coat hypertension

Abstract: A possible relationship between end-organ damage and insulin resistance in patients with WCH exists.

Cited by 9 publications

References 37 publications

Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?

Metabolic syndrome in subjects with white-coat hypertension: impact on left ventricular structure and function

Body Mass Index and Waist Circumference Affect Lipid Parameters Negatively in Turkish Women

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