Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise

Friedl, Walter; Mair, Johannes; Thomas, S.; Pichler, Max; Puschendorf, Bernd

doi:10.1016/s0009-8981(98)00217-4

Cited by 37 publications

(25 citation statements)

References 12 publications

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“…Another possible explanation was the measurement of resting BNP levels in this study since BNP levels are reported to increase with exercise. 22,23) In conclusion, in patients with dyspnea and diastolic dysfunction but having preserved left ventricular systolic function, BNP levels can provide some indication of the severity of heart failure and cardiac functional capacity determined by CPET. We believe that measuring BNP levels, which is simple and noninvasive, can be easily and rapidly determined in emergency departments to guide therapy, follow the response to therapy, and predict the exercise capacity of the patients.…”

Section: Discussionmentioning

confidence: 97%

Brain Natriuretic Peptide Levels and Cardiac Functional Capacity in Patients With Dyspnea and Isolated Diastolic Dysfunction

et al. 2007

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SUMMARYDiastolic heart failure affects approximately 40%-50% of patients presenting with signs and symptoms of heart failure. The aim of this study was to investigate the relationship between brain natriuretic peptide (BNP) levels and functional capacity in patients admitted with dyspnea and diagnosed with isolated diastolic dysfunction.Fifty-four patients (mean age, 57.4 ± 8.5 years) with class-2 dyspnea with isolated diastolic dysfunction were enrolled. Serum levels of BNP were measured, and peak oxygen consumption (peak VO 2 ), anaerobic threshold (AT), and metabolic equivalent (MET) values were determined with a cardiopulmonary exercise test (CPET).There was a negative correlation between BNP levels and exercise duration (P < 0.05, r = -0.304), AT (P < 0.05, r = -0.380), and number of MET (P < 0.05, r = -0.322) determined by CPET. When patients were divided into 2 groups according to BNP levels; BNP ≤ 50 pg/mL (n = 40) versus BNP > 50 pg/mL (n = 14) and analyzed, those with BNP levels > 50 pg/mL had lower peak VO 2 (P = 0.05) and anaerobic threshold (P = 0.01) compared with patients with BNP ≤ 50 pg/mL.The results suggest that BNP levels provide an indication about the functional capacity determined by CPET in patients admitted with dyspnea and isolated diastolic dysfunction. (Int Heart J 2007; 48: 97-106) Key words: Diastolic dysfunction, Brain natriuretic peptide, Cardiopulmonary exercise test HEART failure (HF) is an important cause of mortality and morbidity worldwide.1) Its prevalence increases as the age of the population increases. Approximately 40%-50% of HF patients have diastolic HF with preserved left ventricular systolic function. 2)Dyspnea is one of the most common symptoms of patients admitted to emergency, cardiology, and pulmonary facilities. It is sometimes difficult for a physiFrom the

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Section: Discussionmentioning

confidence: 97%

Brain Natriuretic Peptide Levels and Cardiac Functional Capacity in Patients With Dyspnea and Isolated Diastolic Dysfunction

et al. 2007

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“…These include the vasoconstrictor and antinatriuretic systems, such as the sympathetic nervous system and the renin-angiotensin-aldosterone axis, as well as the upregulation of the natriuretic peptides, as delineated by the high synthesis and release of ANP and BNP (Moe et al 1993). Indeed, many studies have demonstrated that plasma levels of these peptides rise significantly in clinical and experimental CHF (Asano et al 1999;Friedl et al 1999).…”

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confidence: 99%

“…BNP is considered to be a more reliable prognostic marker than ANP in patients with CHF (Friedl et al 1999), and BNP levels found in the atrium are proportionally related to the severity of the disease (Mukoyama et al 1991;Langenickel et al 2000). Doyama et al (1998) observed that BNP levels rise in response to increased atrial pressure and that atrial expression of BNP mRNA is correlated with that of ANP, assuming that these two genes may share some common regulatory mechanism, of which atrial pressure was suggested to be of major importance.…”

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confidence: 99%

Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

Bialik

Abassi²,

Hammel

et al. 2001

J Histochem Cytochem.

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S U M M A R YThe natriuretic peptides are believed to play an important role in the pathophysiology of congestive heart failure (CHF). We utilized a quantitative cytomorphometric method, using double immunocytochemical labeling, to assess the characteristics of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in atrial granules in an experimental model of rats with CHF induced by aortocaval fistula. Rats with CHF were further divided into decompensated (sodium-retaining) and compensated (sodium-excreting) subgroups and compared with a sham-operated control group. A total of 947 granules in myocytes in the right atrium were analyzed, using electron microscopy and a computerized analysis system. Decompensated CHF was associated with alterations in the modal nature of granule content packing, as depicted by moving bin analysis, and in the granule density of both peptides. In control rats, the mean density of gold particles attached to both peptides was 347.0 Ϯ 103.6 and 306.3 Ϯ 89.9 gold particles/ m 2 for ANP and BNP, respectively. Similar mean density was revealed in the compensated rats (390.6 Ϯ 81.0 and 351.3 Ϯ 62.1 gold particles/ m 2 for ANP and BNP, respectively). However, in rats with decompensated CHF, a significant decrease in the mean density of gold particles was observed (141.6 Ϯ 67.3 and 158.0 Ϯ 71.2 gold particles/ m 2 for ANP and BNP, respectively; p Ͻ 0.05 compared with compensated rats, for both ANP and BNP). The ANP:BNP ratio did not differ between groups. These findings indicate that the development of decompensated CHF in rats with aortocaval fistula is associated with a marked decrease in the density of both peptides in atrial granules, as well as in alterations in the quantal nature of granule formation. The data further suggest that both peptides, ANP and BNP, may be regulated in the atrium by a common secretory mechanism in CHF.

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“…This suggests that central NTproBNP (ng/mL) may also take part in the neuro-modulatory system that controls emotional behavior and the stress hormone cascade [16]. While there are data in the medical literature on NTproBNP (ng/mL) responses to acute physical stress [17][18][19][20][21][22][23], few data are available on systemic NTproBNP (ng/mL) responses to acute psychological and physiological stress. Moreover, it has been proposed that the cardiac endocrine response may be regulated differently by several types of stressors [24][25].…”

Section: Introductionmentioning

confidence: 99%

The effect of the Wingate Anaerobic Test on NTproBNP, lactate and blood pressure in wrestlers and untrained young healthy males

Saghiv¹,

Cummings²,

Kusser³

et al. 2017

J Integr Cardiol

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Purpose: To investigate the influence of the WAnT on blood pressure, lactate, and NTproBNP in trained Wrestlers and untrained young males.Methods: 20 males (n=20), ages 18-25 underwent the WAnT. The study included 2 groups. Group 1 included 10 untrained individuals, and group 2 included 10 wrestlers. NTproBNP (ng/mL), lactate (mmol/ L), and blood pressure (mmHg) were measured at rest, immediate-post, two minutes post, and ten minutes post. The mechanical outputs (W) calculated for each subject. NTproBNP was analyzed utilizing ELIZA.Results: The wrestler's resting NTproBNP levels were higher (35.5 ± 7.59 vs. 35.15 ± 4.82 accordingly), with non-significant differences between the groups. Immediate Post NTproBNP was higher for wrestlers (40.25 ± 14.08 vs. 37.33 ± 9.94) with a positive and strong correlation between PP and IP NTproBNP (r = 0.85). While the untrained had a substantially higher post 10 NTproBNP (45.07 ± 11.75 vs. 32 ± 5.57), both group's NTproBNP was elevated post 10 minutes with a significant difference from post 2 minutes values (p=0.035). PP was significantly higher for the wrestlers (1031.6 ± 188.65 vs. 960.91 ± 189.01). No significant differences were found between groups for RPP and RMP. Conclusions:NTproBNP values were within the ranges reported in the literature. The WAnT did not put any of the subjects at risk due to cardiac stress. The recovery dynamics regarding NTproBNP were different between groups. Wrestlers recovered rapidly with a slight elevation 10 minutes post-test, while the untrained recovered slowly with a significant elevation of NTproBNP 10 minutes post-test.

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Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise

Cited by 37 publications

References 12 publications

Brain Natriuretic Peptide Levels and Cardiac Functional Capacity in Patients With Dyspnea and Isolated Diastolic Dysfunction

Brain Natriuretic Peptide Levels and Cardiac Functional Capacity in Patients With Dyspnea and Isolated Diastolic Dysfunction

Evaluation of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Atrial Granules of Rats with Experimental Congestive Heart Failure

The effect of the Wingate Anaerobic Test on NTproBNP, lactate and blood pressure in wrestlers and untrained young healthy males

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