Relationship between the interleukin‐6‐174 gene and mannose‐binding lectin codon 54 gene polymorphisms and condyloma acuminatum

Aydoğan, Kenan; Özakın, Cüneyt; Sarıcaoğlu, Hayriye; Sığırlı, Deniz; Oral, Barbaros

doi:10.1111/jdv.12273

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…The results of the present study showed that TC genotype of the +510 SNP is protective of sores in the genitals. Similarly, Aydogan et al (2014) had found that IL-6 gene at -174 SNP has an impact on genital warts. Most oral lesions among HIV positive patients are caused by opportunistic pathogens such as Candida spp or HSV, which manifest because of weakened immunity.…”

Section: Discussionmentioning

confidence: 98%

Research Article Genetic polymorphism at Interleukin-7 receptor gene at +510 position and its impact on pain and other symptoms among HIV and AIDS patients

Nangammbi¹,

Moloro²,

Samie³

2019

Genet. Mol. Res.

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Genetic polymorphism of cytokine genes has been shown to be associated with susceptibility to diseases. We investigated the frequency of the IL-7 receptor-α +510 CT SNP in relation to pain and other symptoms among HIV and AIDS patients attended at various South African hospitals for treatment. Demographic as well as clinical data was obtained through structured interviews and patient files were consulted. A total of 107 mouth wash samples were obtained from volunteers, and DNA was extracted from these samples using the Qiagen protocol. Genotyping of the IL-7 receptor +510 CT SNP was conducted using sequence specific PCR. The CC and TC genotypes were the most common, while the TT genotype was rare (47.7, 45.8 and 6.5% respectively). The CC genotype was more common among patients who had body pain at the time they went for testing (χ 2 = 4.75; P = 0.029) while the TC genotype was more common among those that did not have pain (χ 2 = 6.86; P = 0.009). The TC genotype was also more common among patients who did not have genital sores (χ 2 = 4.663; P = 0.031). The TT genotype was more common among patients whose infection state had improved as well as among those who had tuberculosis, although the differences were not significant. We concluded that the CC genotype is associated with pain while the TC ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (4): gmr18292 T.C. Nangammbi et al. 2 genotype is protective of pain and genital sores. Further studies will be needed to confirm these hypotheses in larger populations.

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Section: Discussionmentioning

confidence: 98%

Research Article Genetic polymorphism at Interleukin-7 receptor gene at +510 position and its impact on pain and other symptoms among HIV and AIDS patients

Nangammbi¹,

Moloro²,

Samie³

2019

Genet. Mol. Res.

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“…Previous studies have demonstrated that the T helper (Th) type 1/2 cell imbalance plays an important role in the incidence and recurrence of CA [5,6]. However, the mechanisms underlying this imbalance remain uncharacterized.…”

Section: Introductionmentioning

confidence: 99%

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Zeng

2020

J Infect Dev Ctries

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Introduction: An imbalance in type 1 (Th1) and type 2 (Th2) T helper cells is associated with the development and recurrence of condyloma acuminatum (CA); however, the mechanisms underlying this imbalance remain unknown. We investigated soluble fibrinogen-like protein 2 (sFGL2), which is an effector of regulatory T cells (Tregs), to determine its role in the Th1/Th2 imbalance of CA. Methodology: Lesion and blood samples were obtained from 30 CA patients, and these samples were compared with genital skin and blood samples from 20 control subjects. Serum sFGL2, mRNA, and protein levels were estimated using ELISA, quantitative real-time polymerase chain reaction, and western blot, respectively. Immunohistochemical analyses were also conducted. Results: Compared to controls, CA patients had decreased serum sFGL2 levels. However, sFGL2 mRNA and protein levels in the lesions of CA patients were signiﬁcantly increased. Interleukin (IL)-4 and Foxp3 mRNA levels were upregulated, and interferon (IFN)-γ levels were downregulated in CA patients compared to those in controls. Additionally, the sFGL2 mRNA level positively correlated with Foxp3 and IL-4 levels and negatively correlated with IFN-γ and IL-17 levels. Conclusion: sFGL2 contributes to the underlying Th1/Th2 imbalance in CA pathogenesis.

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“… 2 , 3 Previous studies have suggested that other factors including host immunogenetics are important in the pathogenesis of these HPV-related diseases. 4 , 5 Some studies have shown that the polymorphisms of human leukocyte antigen (HLA) genes are related with HPV infection. 6 , 7 HLA-G and HLA-DQB1 polymorphisms may represent risk factors in HPV infected subjects.…”

Section: Introductionmentioning

confidence: 99%

Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population

Wang

Chu

et al. 2019

The Brazilian Journal of Infectious Diseases

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Relationship between the interleukin‐6‐174 gene and mannose‐binding lectin codon 54 gene polymorphisms and condyloma acuminatum

Abstract: These results suggest that the IL-6 G/G and MBL AA gene polymorphisms are potential risk factors and that the IL-6 G/C and MBL AB polymorphisms are a protective factor for occurrence and recurrence of CA.

Cited by 6 publications

References 36 publications

Research Article Genetic polymorphism at Interleukin-7 receptor gene at +510 position and its impact on pain and other symptoms among HIV and AIDS patients

Research Article Genetic polymorphism at Interleukin-7 receptor gene at +510 position and its impact on pain and other symptoms among HIV and AIDS patients

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population

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