Remote ischemic conditioning temporarily improves antioxidant defense

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

“…TBARS levels were significantly higher in I/R group when compared to Per and Per+HSS, Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats Brito MVH et al suggesting that they were capable to maintain an antioxidant defense higher than the I/R. This maintenance of antioxidant defense, promote destruction of oxygen free radicals, reducing lipid peroxidation mediated by these reactive species originated in renal parenchyma 23 .…”

Perconditioning combined with postconditioning on kidney ischemia and reperfusion

“…Based on fact that perconditioning is performed in a distant tissue, is a non-invasive procedure and do not increase the surgical time, thus does not require direct access to the artery and could be easily applied during the surgery or endovascular surgery [15][16][17][18][19] ; this ischemic conditioning must be test in human IR syndromes 20,31 . However, new studies aim to understanding the mechanism are need 32 .…”

“…We tested three cycles of 5 min of reperfusion followed by 5 min ischemia, interval referred to previous literature 18,22,32 . Whether, the ischemic per and postconditioning plays its role in an 'on-off' style or a 'dose-dependent' one 22 …”

Kidney ischemia and reperfunsion syndrome: effect of lidocaine and local postconditioning

“…Further studies are required before the clinical use of lidocaine, especially using other analysis parameters such as oxidative stress and cell viability, not tested in this initial work 26 . Furthermore, there is controversy in the literature on whether the ischemic postconditioning is influenced by the number of cycles or by the conditioning time 27 .…”