Repair of Segmental Defects with Nano-hydroxyapatite/Collagen/PLA Composite                 Combined with Mesenchymal Stem Cells

Zhou, Dongsheng; Zhao, Kun; Li, Yong; Cui, Fuzhai; Lee, I. S.

doi:10.1177/0883911506068554

Cited by 42 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, but an increased osteoblast adhesion was discovered on nano-sized calcium orthophosphate powders with higher Ca/P ratios [189], which points out to some advantages of apatites over other calcium orthophosphates. Furthermore, a histological analysis revealed a superior biocompatibility and osteointegration of bone graft substitutes when nano-sized HA was employed in biocomposites [190][191][192]. However, data are available that nano-sized HA could inhibit growth of osteoblasts in a dose-dependent manner [193].…”

Section: Micron-and Submicron-sized Calcium Orthophosphates Versus Thmentioning

confidence: 99%

See 1 more Smart Citation

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

View full text Add to dashboard Cite

Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

show abstract

Section: Micron-and Submicron-sized Calcium Orthophosphates Versus Thmentioning

confidence: 99%

“…[89,100,226,511,631,735,789]. Furthermore, similar terms "nano-HA" [103,575,608,659,681,692], "nano-hydroxyapatite"[42, 87,91,92,96,97,102,119,190,191,294,295,314,338,451,459,486,492,578,583,606,627,628,641,664,666,677,682,685,687,693,698,701,703,705,770,773], nano-fluorapatite [104,684] and "nanohydrox...…”

Section: Post-conclusion Remarksmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

View full text Add to dashboard Cite

show abstract

“…Bone defects caused by tumor reconstruction, chronic infection, or traumatic bone loss create a major surgical problem [1]. The majority of fractures heal well under standard conservative or surgical therapy.…”

Section: Introductionmentioning

confidence: 99%

“…This treatment presents serious problems with donor site morbidity, prolonged operation time, and the limited availability of graft materials [3]. Allograft bone also has concerns related to disease transmission risk and infection, explaining why synthetic bone grafts are increasingly being employed in the clinical field [1]. Certain biomaterials can repair or replace damaged or diseased tissue by mimicking the natural extracellular matrix (ECM) [4].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

View full text Add to dashboard Cite

Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

show abstract

“…Meanwhile, HA promotes the adsorption of many proteins and other macromolecules and leads to a biological layer that favors cell attachment and osteogenic differentiation [89].…”

Section: Composite Hydrogels With Mineral Phases For Hard Tissue Regementioning

confidence: 99%

Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc

et al. 2012

View full text Add to dashboard Cite

Hydrogels currently represent a powerful solution to promote the regeneration of soft and hard tissues. Primarily, they assure efficient bio-molecular interactions with cells, also regulating their basic functions, guiding the spatially and temporally complex multi-cellular processes of tissue formation, and ultimately facilitating the restoration of structure and function of damaged or dysfunctional tissues. In order to overcome basic drawbacks of traditional synthesized hydrogels, many recent strategies have been implemented to realize multi-component hydrogels based on natural and/or synthetic materials with tailored chemistries and different degradation kinetics. Here, a critical review of main strategies has been proposed based on the use of hydrogels-based devices for the regeneration of complex tissues, i.e., osteo-chondral tissues and intervertebral disc.

show abstract

Repair of Segmental Defects with Nano-hydroxyapatite/Collagen/PLA Composite Combined with Mesenchymal Stem Cells

Cited by 42 publications

References 20 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc

Contact Info

Product

Resources

About