Research Progress on B Cells and Thoracic Aortic Aneurysm/Dissection

Hou, Yue; Li, Yan; Liu, Bingqing; Wang, Hong; Liu, Chang; Xia, Wei

doi:10.1016/j.avsg.2021.11.018

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Along with the ability to produce antibodies, B cells can contribute to the development of disease by presenting autoantigens to autoreactive T cells and by secreting proinflammatory cytokines and chemokines that amplify the inflammatory response ( 27 ). In patients with abdominal aortic aneurysms (AAAs), B cells are abundant, and depletion of B cells can prevent experimental AAA formation in mice ( 28 ). Although the importance of circulating B cells in IA is not well-documented, several studies have shown that humoral immunity plays a role in IA formation ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm

Liu

Chan

et al. 2022

Front. Immunol.

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BackgroundIncreasing evidence supports a critical role of chronic inflammation in intracranial aneurysm (IA). Understanding how the immunological alterations in IA provides opportunities for targeted treatment. However, there is a lack of comprehensive and detailed characterization of the changes in circulating immune cells in IA.ObjectiveTo perform a comprehensive and detailed characterization of the changes in circulating immune cells in patients with IA.MethodsPeripheral blood mononuclear cell samples from IA patients (n = 26) and age-and sex-matched healthy controls (HCs, n = 20) were analyzed using high dimensional mass cytometry, and the frequency and phenotype of immune cell subtypes were assessed.ResultsWe identified 28 cell clusters and found that the immune signature of IA consists of cluster changes. IA patients exhibited dysfunction of immunity, with dysregulation of CD4+ T-cell clusters, increased B cells and monocytes, and decreased CD8+ T cells, DNT cells, and DPT cells. Moreover, compared with findings in HC, IA was associated with enhanced lymphocyte and monocyte immune activation, with a higher expression of HLA-DR, CXCR3, and CX3CR1. In addition, the expression of TLR4, p-STAT3, and the exhaustion marker PD1 was increased in T cells, B cells, and NK cells in IA patients.ConclusionsOur data provide an overview of the circulating immune cell landscape of IA patients, and reveal that the dysfunction of circulating immunity may play a potential role in the development of IA.

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Section: Discussionmentioning

confidence: 99%

High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm

Liu

Chan

et al. 2022

Front. Immunol.

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“…B cells play a key role in adaptive immunity and participate in the pathogenesis of AD, mainly through their ability to detect and process antigens [66,67]. Saraff et al revealed that in an angiotensin II (Ang II)-induced AD model, B cells mainly infiltrated the media of the vessel wall.…”

Section: B Cellsmentioning

confidence: 99%

Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection

Li,

Cheng

et al. 2023

IJMS

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Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD.

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Cell Type-Specific Relationships Among Immune Cells in Human Aortic Dissection Tissue

NEGOTO,

AOKI,

OHSHIMA

et al. 2023

Kurume Med. J.

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Research Progress on B Cells and Thoracic Aortic Aneurysm/Dissection

Cited by 4 publications

References 49 publications

High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm

High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm

Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection

Cell Type-Specific Relationships Among Immune Cells in Human Aortic Dissection Tissue

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