Research progress on the relationship between zinc deficiency, related micro<scp>RNA</scp>s, and esophageal carcinoma

Liu, Congmin; Liang, Dan; Jin, Jing; Li, Dao-juan; Zhang, Yachen; Gao, Zhaoyu; He, Yutong

doi:10.1111/1759-7714.12493

Cited by 17 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EC is one of the most common cancers worldwide [1,2]; due to a high incidence of recurrence, its prognosis is poor [3]. miRNAs play a critical role in regulating tumorigenesis and metastasis of EC [4,5], and some miRNAs have been identified as prognostic markers or potential therapeutic targets [6,7]. miRNAs can act as either oncogenes or tumor suppressors to modulate growth, angiogenesis, drug or chemoresistance, invasion, and metastasis of malignant cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma

Wang

Yang

et al. 2019

Aging

View full text Add to dashboard Cite

We analyzed data from two non-coding RNA profiling arrays made available by the Gene Expression Omnibus (GEO) and found 17 miRNAs with remarkable differential expression between malignant and normal esophageal tissue. Correlation analysis between expression of these 17 miRNAs and patients' clinicopathological characteristics showed that miR-203 was down-regulated in esophageal carcinoma (EC) tissues and was significantly associated with lymph node metastasis and poor overall survival. Overexpression of miR-203 significantly attenuated cellular proliferation, migration and invasion by EC cells in culture. Additionally, gene expression profiles and bioinformatics analysis revealed KIF5C to be a direct target of miR-203, and KIF5C overexpression partially counteracted the tumor inhibitory effects of miR-203 on EC cells. We also observed that miR-203, reduced KIFC5 protein levels, promoted cytoplasmic accumulation of Axin2, and reversed the invasive phenotype of EC cells. Taken together, these data demonstrate that miR-203 is a tumor suppressor in EC cells and its expression level could potentially be used as a prognostic indicator for EC patient outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma

Wang

Yang

et al. 2019

Aging

View full text Add to dashboard Cite

show abstract

“…There is a link between cancer occurrence and inflammatory factors induced by zinc deficiency [ 8 ]. Many researchers have focused on the ZD-related tumorigenesis on esophageal and gastric cancers [ 23 , 24 ]. However, its influences on colon tumorigenesis and its related mechanism remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation

Yin

Zhang

Wen

et al. 2021

Aging

View full text Add to dashboard Cite

Accumulating evidence has shown that dietary zinc deficiency (ZD) increases the risk of various cancers including esophageal and gastric cancer. However, the role of ZD in colon tumorigenesis is unknown and the related mechanisms need to be investigated. Apc min/+ mice, widely used to mimic the spontaneous process of human intestinal tumor, were used to construct a ZD mice model in this study. Inflammatory mediators such as COX-2, TNF-α, CCL, CXCL, and IL chemokines families were evaluated using real-time PCR and Enzyme-linked immunosorbent assay (ELISA). Besides, the immunoreactivities of cyclin D1, PCNA, and COX-2 in the colon were detected by immunohistochemistry. We found that zinc deficiency could promote colon tumorigenesis in Apc min/+ mice. The mechanisms are involved in the upregulation of inflammatory mediators: COX-2, TNF-α, CCL, CXCL, and IL chemokines families. Administration of celecoxib, a selective COX-2 inhibitor, decreased colon tumorigenesis in Apc min/+ mice via inhibiting the inflammatory mediators. ZD plays an important role in the process of colon cancers of Apc min/+ mice. Celecoxib attenuates ZD-induced colon tumorigenesis in Apc min/+ mice by inhibiting the inflammatory mediators. Our novel finding would provide potential prevention of colorectal tumor-induced by ZD.

show abstract

“…The nutritional intervention also gives supportive treatment by providing adequate micronutrients. It has been shown that vitamin C, zinc, and vitamin B has been depleted in cancer patients, and correlated with anemia [11][12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

“…Besides, vitamin A is also known to increase epithelial cell formation and collagen deposition by fibroblasts. Therefore, vitamin A is also recommended for open chronic wounds 12 .…”

Section: Discussionmentioning

confidence: 99%

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Tyas¹,

As’ad²,

Safitri³

et al. 2020

GMJ

View full text Add to dashboard Cite

Nutrition is a part of cancer management during therapy, recovery, remission, and recurrence prevention. Malnutrition and cachexia often occur in cancer patients and influence morbidity, mortality, and quality of life, especially in the advanced stage of malignancy. We reported a case of cutaneous lymphoma with anemia and hypoalbuminemia in the terminal condition. This case report focuses on nutritional therapy and palliative care on nutrition. We reported a case of a 40-year-old-man with Cutaneous Lymphoma (CL) and moderate protein-energy malnutrition that was developed to severe protein-energy malnutrition due to difficulty in dietary access. He had an eating problem because of multiple tumors and ulcers on his mouth. We provided access for parenteral nutrition from Central Venous Catheter (CVC) and orogastric tube (OGT) for enteral feeding. Even though the dietary target was never accomplished, there was a slight recovery on hypoalbuminemia and renal function during hospitalization. This case showed a considerable challenge in nutritional therapy due to limited dietary access. Since death was inevitable, we have tried different dietary access to provide adequate intake.

show abstract

Research progress on the relationship between zinc deficiency, related microRNAs, and esophageal carcinoma

Cited by 17 publications

References 46 publications

Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma

Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma

Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Contact Info

Product

Resources

About