Resistance to commonly used insecticides and underlying mechanisms of resistance in Aedes aegypti (L.) from Sri Lanka

Fernando, H.S.D.; Saavedra-Rodríguez, Karla; Perera, Rushika; Black, William C.; Silva, B. G. D. N. K. De

doi:10.1186/s13071-020-04284-y

Cited by 25 publications

(15 citation statements)

References 46 publications

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“…For instance, insecticide-resistant Ae. aegypti significantly increased oxidase activity ( Little et al., 2018 ; Fernando et al., 2020 ; Contreras-Perera et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of susceptible Culex quinquefasciatus larvae in Indonesia to different insecticides through metabolic enzymes and the histopathological midgut

Subahar¹,

Aulia²,

Yulhasri³

et al. 2022

Heliyon

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“…For instance, insecticide-resistant Ae. aegypti significantly increased oxidase activity ( Little et al., 2018 ; Fernando et al., 2020 ; Contreras-Perera et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of susceptible Culex quinquefasciatus larvae in Indonesia to different insecticides through metabolic enzymes and the histopathological midgut

Subahar¹,

Aulia²,

Yulhasri³

et al. 2022

Heliyon

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“…Data available from Bangladesh, Cambodia, Sri Lanka, and Vietnam indicated high to very high levels of resistance in Ae. aegypti adults to pyrethroids and, in some cases, to the organophosphate malathion [29][30][31]. Despite high levels of resistance, dengue programs continued to use pyrethroids for space spraying, due to a lack of acceptable alternative products or methods for emergency control.…”

Section: Insecticide Resistance Managementmentioning

confidence: 99%

Management of insecticides for use in disease vector control: Lessons from six countries in Asia and the Middle East

2021

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Interventions to control the vectors of human diseases, notably malaria, leishmaniasis and dengue, have relied mainly on the action of chemical insecticides. However, concerns have been raised regarding the management of insecticides in vector-borne disease-endemic countries. Our study aimed to analyze how vector control insecticides are managed in selected countries to extract lessons learned. A qualitative analysis of the situation of vector control insecticides management was conducted in six countries. Multi-stakeholder meetings and key informer interviews were conducted on aspects covering the pesticide lifecycle. Findings were compared and synthesized to extract lessons learned. Centrally executed guidelines and standards on the management of insecticides offered direction and control in most malaria programs, but were largely lacking from decentralized dengue programs, where practices of procurement, application, safety, storage, and disposal were variable between districts. Decentralized programs were better at facilitating participation of stakeholders and local communities and securing financing from local budgets. However, little coordination existed between malaria, visceral leishmaniasis and dengue programs within countries. Entomological capacity was concentrated in malaria programs at central level, while dengue and visceral leishmaniasis programs were missing out on expertise. Monitoring systems for insecticide resistance in malaria vectors were rarely used for dengue or visceral leishmaniasis vectors. Strategies for insecticide resistance management, where present, did not extend across programs or sectors in most countries. Dengue programs in most countries continued to rely on space spraying which, considering the realities on the ground, call for revision of international guidelines. Vector control programs in the selected countries were confronted with critical shortcomings in the procurement, application, safety measures, storage, and disposal of vector control insecticides, with implications for the efficiency, effectiveness, and safety of vector control. Further international support is needed to assist countries in situation analysis, action planning and development of national guidelines on vector control insecticide management.

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“…2002). Around the world, mosquito species have developed a variety of mechanisms to evade commonly used insecticides such as pyrethroids and organophosphates (Moyes et al 2017, Fernando et al 2020, Brogdon et al 1992. Additionally, the concern for off-target effects on beneficial insects, including crucial pollinators such as Apis mellifera, grows (Goulson et al 2015, Reid et al 2020, Kruegar et al 2021.…”

Section: Introductionmentioning

confidence: 99%

“…Around the world, mosquito species have developed a variety of mechanisms to evade commonly used insecticides such as pyrethroids and organophosphates (Moyes et al . 2017, Fernando et al . 2020, Brogdon et al .…”

Section: Introductionmentioning

confidence: 99%

Diols and sugar substitutes in attractive toxic sugar baits targetingAedes aegyptiandAedes albopictus(Diptera: Culicidae) mosquitoes

Pullmann-Lindsley¹,

Bartlett-Miller²,

Pitts³

2023

Preprint

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Around the world, mosquitoes continue to transmit disease-causing pathogens while also developing resistance to insecticides. We previously discovered that a generally regarded as safe (GRAS) compound, 1,2-propanediol, reduces adult mosquito survivorship when ingested. In this study, we assess and compare five more chemically related compounds for mosquito lethality and eight GRAS sugar substitutes to determine toxic effects. We conducted a series of feeding assays to determine if ingesting the compounds influenced mosquito mean survivorship in locally collected lab-reared populations of Aedes aegypti (Linnaeus, 1762) and Aedes albopictus (Skuse, 1894) mosquitoes. Our results indicate that 1,2-propanediol, 1,3-propanediol, 1,5-pentanediol, 1,6-hexanediol, 2-methyl-1,3-propanediol, DL-dithiothreitol, acesulfame potassium, allulose, erythritol, sodium saccharin, stevia, and sucralose significantly reduced the mean survivorship of one or both species. Short-term trials with the most toxic compounds revealed that they could substantially affect survivorship after 24 hours. We also found that many of the compounds yielded different responses in the two species and that male mosquitoes expired to a greater extent than female mosquitoes. These findings indicate that several of the compounds may be highly effective for local mosquito vector population and disease control through functioning as components in attractive toxic sugar bait systems (ATSBs)

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Resistance to commonly used insecticides and underlying mechanisms of resistance in Aedes aegypti (L.) from Sri Lanka

Cited by 25 publications

References 46 publications

Assessment of susceptible Culex quinquefasciatus larvae in Indonesia to different insecticides through metabolic enzymes and the histopathological midgut

Assessment of susceptible Culex quinquefasciatus larvae in Indonesia to different insecticides through metabolic enzymes and the histopathological midgut

Management of insecticides for use in disease vector control: Lessons from six countries in Asia and the Middle East

Diols and sugar substitutes in attractive toxic sugar baits targetingAedes aegyptiandAedes albopictus(Diptera: Culicidae) mosquitoes

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