Resistant Gestational Trophoblastic Neoplasia Patients Treated with 5-Fluouracil plus Actinomycin D

Abstract

The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity.

Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

“…The treatment modalities include suction dilation and curettage and combination chemotherapy in case of malignancy (Manopunya et al, 2012;Oranratanaphan et al,2014). Invasive mole that follows complete and partial hydatiform mole is characterized with invasion of the molar villi to the myometrium.…”

Quality of Life in Gestational Trophoblastic Neoplasia Patients after Treatment in Thailand

“…This finding may be explained by the modality of treatment in GTN. Although hysterectomy were necessary in some cases, the majority of GTN patients could be cured by chemotherapy alone which can preserve uterus and ovaries (Pongsaranantakul and Kietpeerakool, 2009;Seckl et al, 2010;Manopunya and Suprasert, 2012;Ozalp et al, 2014). Previous study (Pinar et al, 2012)showed that hysterectomy had negative effects on body image and self-esteem in women affected by gynecologic cancer.…”

FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report

“…The FA regimen is effective in low-and high-risk GTN patients, but not in PSTT patients. Additionally, it may be administered as a primary chemotherapy regimen for the treatment of high-risk GTN patients (13,14). It is reported that the EMA/CO regimen is considered to be highly effective for the treatment of high-risk GTN, as it exhibits good efficacy and is well-tolerated by patients.…”