Resisting resistance

Sina, Barbara J.; Aultman, Kathryn

doi:10.1016/s1471-4922(01)02007-4

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Insecticide resistance is a major obstacle to the control of vector-borne diseases [7][8][9]. Many studies have suggested that the insecticide resistance phenotype evolves rapidly based on the selection of major eVect genes [10,11].…”

Section: Introductionmentioning

confidence: 99%

Cloning and characterization of NYD-OP7, a novel deltamethrin resistance associated gene from Culex pipiens pallens

Sun

Wang

et al. 2007

Pesticide Biochemistry and Physiology

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One mosquito opsin gene, NYD-OP7, has been cloned from Culex pipiens pallens. An open reading frame (ORF) of 1116 bp was found to encode a putative 371 amino acids protein which exhibits high identity with opsins from Aedes and Anopheles mosquitoes. Transcript expression of NYD-OP7 was determined by real-time PCR in all life stages of deltamethrin-susceptible and -resistant strains of the Culex mosquito. The results demonstrated that this gene is expressed at all developmental stages, and it is expressed predominantly at the pupae and adult stages. Meanwhile, in pupae and adults, NYD-OP7 is overexpressed in deltamethrin-resistant strain than in -susceptible strain. Importantly, stable expression of NYD-OP7 in the mosquito C6/36 cells can confer moderate deltamethrin resistantce. Our study provides the Wrst direct evidence that increased expression of an opsin gene may play some role in the development of deltamethrin resistantce in Cx. pipiens pallens.

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Section: Introductionmentioning

confidence: 99%

Cloning and characterization of NYD-OP7, a novel deltamethrin resistance associated gene from Culex pipiens pallens

Sun

Wang

et al. 2007

Pesticide Biochemistry and Physiology

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“…However, chemical-based control has stimulated debate regarding the harmful effects of prolonged use of synthetic insecticides on human health and the environment (Attaran et al 2000;Longnecker et al 2001Longnecker et al , 2002, and the priorities for funding in vector control research (Curtis 2000;Hoffman 2000). Mosquito resistance to insecticides is also a matter of concern (Sina & Aultman 2001).…”

Section: Introductionmentioning

confidence: 99%

Population control of the malaria vectorAnopheles pseudopunctipennisby habitat manipulation

Bond

Rojas

Arredondo‐Jiménez

et al. 2004

Proc. R. Soc. Lond. B

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Insect vector-borne diseases continue to present a major challenge to human health. Understanding the factors that regulate the size of mosquito populations is considered fundamental to the ability to predict disease transmission rates and for vector population control. The mosquito, Anopheles pseudopunctipennis, a vector of Plasmodium spp., breeds in riverside pools containing filamentous algae in Mesoamerica. Breeding pools along 3 km sections of the River Coatan, Chiapas, Mexico were subjected to algal extraction or left as controls in a cross-over trial extending over 2 years. Initial densities of An. pseudopunctipennis larvae were directly proportional to the prevalence of filamentous algae in each breeding site. The extraction of algae brought about a striking decline in the density of An. pseudopunctipennis larvae sustained for about six weeks, and a concurrent reduction in the adult population in both years of the study. Mark-release experiments indicated that dispersal from adjacent untreated areas was unlikely to exert an important influence on the magnitude of mosquito control that we observed. Habitat manipulation by extraction of filamentous algae offers a unique opportunity for sustainable control of this malaria vector. This technique may represent a valuable intervention, complimenting insecticide spraying of households, to minimize Plasmodium transmission rates in Mesoamerica.

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“…The second type of resistance is caused when a point mutation in the region II of the para-type sodium channel genes causes a change in affinity between the insecticide and its binding site or the sodium channel, and it induces a phenotype termed knock-down resistance (KDR) in a range of insecticides [11]- [14]. Insensitivity at the sodium channel target site also leads to cross-resistance between different classes of insecticides [15].…”

Section: Introductionmentioning

confidence: 99%

Modeling Insecticide Resistance in Endemic Regions of Kenya

Wairimu¹,

Ronoh²

2016

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In this study, we develop an SIS model for two types of mosquitoes, a traditional one and one that is resistant to IRS and ITNs. The resistant mosquito develops behavioral adaptation to control measures put in place to reduce their biting rate. They also bite early before dusk and later after dark when people are outside the houses and nets. We determine the effect of the two types of mosquitoes on malaria transmission in Kenya. The basic reproduction number 0  is established as a sharp threshold that determines whether the disease dies out or persists in the population. Precisely, if 0  ≤ 1, the disease-free equilibrium is globally asymptotically stable and the disease always dies out and if 0  > 1, there exists a unique endemic equilibrium which is globally stable and the disease persists. The contribution of the two types of mosquitoes to the basic reproduction number and to the level of the endemic equilibrium is analyzed.

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Resisting resistance

Cited by 15 publications

References 5 publications

Cloning and characterization of NYD-OP7, a novel deltamethrin resistance associated gene from Culex pipiens pallens

Cloning and characterization of NYD-OP7, a novel deltamethrin resistance associated gene from Culex pipiens pallens

Population control of the malaria vectorAnopheles pseudopunctipennisby habitat manipulation

Modeling Insecticide Resistance in Endemic Regions of Kenya

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