Respiratory hazards: clinical and functional assessment in aluminum industry workers

Shaaban, Lamiaa H.; Zayet, Hussein H.; Elghazally, Shimaa A.

doi:10.1016/j.ejcdt.2016.01.004

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…This is called “potroom asthma.” All of these patients experience coughing, shortness of breath, dyspnea on exertion (Doe), phlegm, wheezing, and chest tightness. Chest radiography shows decreased lung fields, irregular opacities, and abnormal patterns of pleura and diaphragm ( Figure 1 ) [ 19 , 62 , 63 ].…”

Section: Pathophysiology and Clinical Manifestationmentioning

confidence: 99%

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Rahimzadeh

Kazemi

et al. 2022

Emergency Medicine International

115

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Aluminum poisoning has been reported in some parts of the world. It is one of the global health problems that affect many organs. Aluminum is widely used daily by humans and industries. Residues of aluminum compounds can be found in drinking water, food, air, medicine, deodorants, cosmetics, packaging, many appliances and equipment, buildings, transportation industries, and aerospace engineering. Exposure to high levels of aluminum compounds leads to aluminum poisoning. Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. Aluminum poisoning can affect blood content, musculoskeletal system, kidney, liver, and respiratory and nervous system, and the extent of poisoning can be diagnosed by assaying aluminum compounds in blood, urine, hair, nails, and sweat. Chelator agents such as deferoxamine (DFO) are used in the case of aluminum poisoning. Besides, combination therapies are recommended.

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Section: Pathophysiology and Clinical Manifestationmentioning

confidence: 99%

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Rahimzadeh

Kazemi

et al. 2022

Emergency Medicine International

115

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“…However, aluminium toxicity is the most common, hazardous, and widely studied. [3][4][5][6][7][8][9][10] Aluminium is an unwanted metal ion in the body, and it enters through air, diet, and medication. The pile-up of inessential aluminium hampers the central nervous system, leading to neurodegenerative disorders such as Parkinson's and Alzheimer's.…”

Section: Introductionmentioning

confidence: 99%

Trivalent metal ion sensor enabled bioimaging and quantification of vaccine-deposited Al³⁺in lysosomes

Kavyashree

Parambil

Silswal

et al. 2023

Analyst

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“…Lethal dose of aluminium chloride in rats and mice ranges from 200 to 1,000 mg/Kg body weight (World Health Organization, 1997). Aluminium exerts its adverse effects in different organs, including the nervous (Bondy, 2016; Noremberg et al., 2015), skeletal muscle (Aghilinejad, Mousavi, Nouri, & Ahmadi, 2012), respiratory (Shaaban, Zayet, Aboufaddan, & Elghazally, 2016), cardiovascular (Schmidt et al., 2016) and urogenital system (Berihu, 2015; Farajbakhsh, Amjadi, Manzoori, Ardalan, & Jouyban, 2016; Sombra et al., 2003). Studies on male reproductive system have shown that aluminium induces toxic effects on sperm morphology, number, viability and motility (Ige & Akhigbe, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Aluminium exerts its adverse effects in different organs, including the nervous (Bondy, 2016;Noremberg et al, 2015), skeletal muscle (Aghilinejad, Mousavi, Nouri, & Ahmadi, 2012), respiratory (Shaaban, Zayet, Aboufaddan, & Elghazally, 2016), cardiovascular (Schmidt et al, 2016) and urogenital system (Berihu, 2015;Farajbakhsh, Amjadi, Manzoori, Ardalan, & Jouyban, 2016;Sombra et al, 2003).…”

mentioning

confidence: 99%

Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin

2020

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Male infertility comprises half of the infertility cases (Miamoto, Minase, Okabe, Ueda & Sengoku, 2015). Various factors including problems in sperm production, maturation and fertilisation ability can affect male reproductive health, leading to male infertility. According to the WHO guidelines (World Health Organization, 2010), semen parameters such as the number, motility and morphology are regarded as reliable predictors of fertility. However, the assessment of these factors may be not sufficient for the diagnosis of infertility, as there are infertile men with a normal spermiogram (Brito, Barth, Bilodeau-Goeseels, Panich, & Kastelic, 2003). Therefore, it seems important to consider other sperm parameters for a clinical diagnosis of infertility. Acrosome reaction plays a critical role in sperm penetration into the oocyte and its fertilisation ability (Jin & Yang, 2017). Since this process

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Respiratory hazards: clinical and functional assessment in aluminum industry workers

Cited by 10 publications

References 18 publications

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Trivalent metal ion sensor enabled bioimaging and quantification of vaccine-deposited Al³⁺in lysosomes

Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin

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Respiratory hazards: clinical and functional assessment in aluminum industry workers

Cited by 10 publications

References 18 publications

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Trivalent metal ion sensor enabled bioimaging and quantification of vaccine-deposited Al3+in lysosomes

Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin

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Trivalent metal ion sensor enabled bioimaging and quantification of vaccine-deposited Al³⁺in lysosomes