Responses of the Normal Human to Infusions of Plasma from Patients with Graves' Disease*

Arnaud, Claude D.; Kneubuhler, Hans A; Seiling, Virginia L.; Wightman, Bruce K.; Engbring, Norman H.

doi:10.1172/jci105235

Cited by 34 publications

(4 citation statements)

References 15 publications

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“…It was suggested (17) that this substance had a pathogenetic role in Graves' disease, since it was found to enhance thyroid function in both the mouse and the guinea pig. Proof of a similar effect in man is an assumption for which, however, suggestive corroboration was recently reported (31). That the substance may be an entity quite distinct from thyrotropin was also postulated, and certainly it has many properties distinct from the hypophysial hormone (32,33).…”

Section: Discussionmentioning

confidence: 82%

Neonatal Graves' Disease

McKenzie

1964

The Journal of Clinical Endocrinology & Metabolism

133

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Assays for the long-acting thyroid stimulator were carried out on serum from 5 children with neonatal Graves' disease and on serum from their mothers. They were carried out also in 2 instances of apparently euthyroid children born of mothers who suffered from Graves' disease. Positive assays were found with the serum from all the mothers and 6 of the children. In one child a half-life of the stimulator was estimated to be of the order of 1 or 2 weeks. It was postulated that neonatal Graves' disease results primarily from the long-acting thyroid stimulator in the maternal circulation reaching the fetal blood stream, and that the clinical consequences are determined largely by the concentration of the stimulator in the mother's blood. (J Clin Endocr 24: 660, 1964)

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Section: Discussionmentioning

confidence: 82%

Neonatal Graves' Disease

McKenzie

1964

The Journal of Clinical Endocrinology & Metabolism

133

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“…Pathogenetic role in hyperthyroidism.-The long-acting th yr oid stimula tor stimulated the human thyroid (67). Nonetheless, the percentage of posi tive assays in patients with hyperthyroidism was relatively low, particularly in the absence of eye changes (68).…”

Section: Long-acting Thyroid Stimulatormentioning

confidence: 99%

The Thyroid

Werner¹,

Nauman²

1968

Annu. Rev. Physiol.

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“…An absence of TSH stimulation of glucose oxidation in liver and testes has previously been reported (13). Evidence has accumulated that indicates LATS can stimulate thyroid gland function in guinea pigs (19), mice (7), sheep (12), and humans (20,21), but not in chicks (22). In vitro effects of LATS on glucose oxidation, similar to those of TSH, can also be obtained using pig and beef thyroid slices (Table VII).…”

Section: Resultsmentioning

confidence: 99%

In vitro stimulation by long-acting thyroid stimulator of thyroid glucose oxidation and 32P incorporation into phospholipids

Field¹,

Remer²,

Bloom³

et al. 1968

J. Clin. Invest.

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AB s T R A C T Long-acting thyroid stimulator (LATS) increased glucose oxidation and 32P incorporation into phospholipids in in vitro experiments with dog thyroid slices. The time course of the response was different from that obtained with thyroid-stimulating hormone (TSH), but was very similar to the delayed effect observed in vivo. During a 45 min incubation, TSH, but not LATS increased glucose oxidation, whereas in longer experiments up to 6 hr, both substances augmented 14CO2 production. Amounts of pooled human gamma globulin equivalent to LATS were inactive. Although TSH stimulated 32P incorporation into phospholipids during a 2 hr incubation, LATS was ineffective. In longer incubations, from 41 to 8 hr. LATS did increase 32P incorporation.The stimulatory effect of LATS was not abolished by anti-TSH antibody capable of neutralizing human TSH. Effects of LATS were also obtained with beef and pig thyroid slices. In addition to stimulation of glucose oxidation in dog thyroid slices, LATS occasionally also stimulated glucose oxidation in dog spleen and liver slices. Despite a 54-fold increase in LATS concentration, a satisfactory dose-response curve could not be demonstrated when 14C02 production was measured.

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Responses of the Normal Human to Infusions of Plasma from Patients with Graves' Disease*

Cited by 34 publications

References 15 publications

Neonatal Graves' Disease

Neonatal Graves' Disease

The Thyroid

In vitro stimulation by long-acting thyroid stimulator of thyroid glucose oxidation and 32P incorporation into phospholipids

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