Rethinking Orbital Imaging

Simon, Guy J. Ben; Annunziata, Christine C.; Fink, James R.; Villablanca, Pablo; McCann, John D.; Goldberg, Robert A.

doi:10.1016/j.ophtha.2005.09.013

Cited by 53 publications

(19 citation statements)

References 19 publications

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“…Ben Simon et al reported that none of the orbital imaging features, including CT and MR imaging features, had a high enough sensitivity to distinguish between malignant and benign orbital tumors [8]. However, our study has shown that some MR imaging features are associated with a malignant disease and have good to excellent interobserver agreement between two observers.…”

Section: Discussionmentioning

confidence: 48%

“…Computed tomography (CT) and magnetic resonance (MR) imaging are making an important impact on the characterization of orbital tumors and play an essential role in the management of these tumors [1–8]. It is well known that thoughtful analyses of CT and MR imaging of the orbit, along with careful history, clinical examination, and observation, are critical elements in the diagnosis and differential diagnosis of orbital tumors.…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that thoughtful analyses of CT and MR imaging of the orbit, along with careful history, clinical examination, and observation, are critical elements in the diagnosis and differential diagnosis of orbital tumors. In general, bony destruction of orbital wall on CT suggests malignant tumor, and hyperostosis underlies benign processes [1, 2, 8–11]. Tumors of the optic nerve sheath complex demonstrate characteristic features on CT and MR imaging contributing to the diagnosis and differential diagnosis [12–14].…”

Section: Introductionmentioning

confidence: 99%

“…Marked enlargement of the orbital mass after compression of the neck on MR images is suggestive of venous varix [1, 6, 16]. Orbital cyst is characterized by no enhancement after contrast administration [4, 5, 8]. Orbital invasion from adjacent structures such as the paranasal sinus, globe, skull base, and nasopharynx shows soft tissue mass extended from these regions, and can be readily diagnosed by using imaging studies and easily confirmed by excisional biopsy [8, 18].…”

Section: Introductionmentioning

confidence: 99%

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Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults

et al. 2010

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PurposeTo prospectively evaluate magnetic resonance (MR) imaging including dynamic contrast-enhanced MR imaging in the differentiation of benign from malignant orbital masses and to evaluate which MR imaging features are most predictive of malignant tumors.Materials and methodsThe study was approved by the institutional review board and signed informed consent was obtained. Nonenhanced, static, and dynamic contrast-enhanced MR imaging was performed in 102 adult patients with an orbital mass. Diagnosis was based on histologic findings. MR imaging features of benign and malignant orbital lesions were evaluated correlated with histological findings. Multivariate logistic regression analysis was employed to identify the best combination of MR imaging features that might be predictive of malignancy.ResultsNonenhanced, static, and dynamic enhancement MR imaging was significantly superior to two other models in prediction of malignancy (p < 0.05). Multivariate logistic regression analysis identified that the most discriminating MR imaging features were isointense mass on T2-weighted imaging and a washout-type time–intensity curve for both observers.ConclusionNonenhanced, static, and dynamic enhancement MR imaging improved differentiation between benign and malignant orbital masses in adult patients.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults

et al. 2010

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“…Both benign and malignant masses of the orbit can have bone destruction [4]. Rarely, even orbital cavernous hemangioma may have bone erosion [5].…”

Section: Discussionmentioning

confidence: 99%

Benign Orbital Tumors with Bone Destruction in Children

Yan

Zhou

2012

PLoS ONE

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PurposeTo present rare benign orbital tumors with bone destruction in children who could not be diagnosed pre-surgically and may simulate malignant ones.MethodsA retrospective review of cases. Clinical, operative and pathological records in all children with a diagnosis of benign orbital tumors who showed remarkable bone destruction at a tertiary Ophthalmic Center in China between Jan 1, 2000 and Dec 31, 2009 were reviewed. All patients had definitive histopathologic diagnosis.ResultsEight patients with benign orbital tumors showed obvious bone destruction, including six cases of eosinophilic granuloma, one case of leiomyoma and one case of primary orbital intraosseous hemangioma. Among them, three patients were females and five patients were males. Tumors were unilateral in all cases, with both the right and left side affected equally. Age ranged from 3 to 7 years (mean 4.1 years). Symptom duration ranged from 1 to 5 weeks (mean 4.8 weeks). Eyelid swelling and palpable mass were the most common complaint. There was no evidence for multifocal involvement in cases with eosinophilic granuloma. Among six patients with eosinophilic granuloma, two were treated with low dose radiation (10 Gy), three received systemic corticosteroid and one was periodically observed only after incisional biopsy or subtotal curettage. There was no postoperative therapeutic intervention in the two patients with leiomyoma and intraosseous hemangioma. All eight patients regained normal vision without local recurrence after a mean follow-up time of 32.8 months.ConclusionBenign orbital tumors such as isolated eosinophilic granuloma, leiomyoma and primary orbital intraosseous hemangioma may show remarkable bone destruction.

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MRI‐Based Radiomics Nomogram for Preoperative Differentiation Between Ocular Adnexal Lymphoma and Idiopathic Orbital Inflammation

Yang

Zhang

Xie

et al. 2022

Magnetic Resonance Imaging

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Background: Ocular adnexal lymphoma (OAL) and idiopathic orbital inflammation (IOI) are malignant and benign lesions for which radiotherapy and corticosteroids are indicated, but similar clinical manifestations make their differentiation difficult. Purpose: To develop and validate an MRI-based radiomics nomogram for individual diagnosis of OAL vs. IOI. Study Type: Retrospective. Population: A total of 103 patients (46.6% female) with mean age of 56.4 AE 16.3 years having OAL (n = 58) or IOI (n = 45) were divided into an independent training (n = 82) and a testing dataset (n = 21).Field Strength/Sequence: A 3-T, precontrast T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and postcontrast T1WI (T1 + C). Assessment: Radiomics features were extracted and selected from segmented tumors and peritumoral regions in MRI before-and-after filtering. These features, alone or combined with clinical characteristics, were used to construct a radiomics or joint signature to differentiate OAL from IOI, respectively. A joint nomogram was built to show the impact of the radiomics signature and clinical characteristics on individual risk of developing OAL. Statistical Tests: Area under the curve (AUC) and accuracy (ACC) were used for performance evaluation. Mann-Whitney U and Chi-square tests were used to analyze continuous and categorical variables. Decision curve analysis, kappa statistics, DeLong and Hosmer-Lemeshow tests were also conducted. P < 0.05 was considered statistically significant. Results: The joint signature achieved an AUC of 0.833 (95% confidence interval [CI]: 0.806-0.870), slightly better than the radiomics signature with an AUC of 0.806 (95% CI: 0.767-0.838) (P = 0.778). The joint and radiomics signatures were comparable to experienced radiologists referencing to clinical characteristics (ACC = 0.810 vs. 0.796-0.806, P > 0.05) or not (AUC = 0.806 vs. 0.753-0.791, P > 0.05), respectively. The joint nomogram gained more net benefits than the radiomics nomogram, despite both showing good calibration and discriminatory efficiency (P > 0.05). Data Conclusion: The developed radiomics-based analysis might help to improve the diagnostic performance and reveal the association between radiomics features and individual risk of developing OAL.

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Rethinking Orbital Imaging

Cited by 53 publications

References 19 publications

Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults

Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults

Benign Orbital Tumors with Bone Destruction in Children

MRI‐Based Radiomics Nomogram for Preoperative Differentiation Between Ocular Adnexal Lymphoma and Idiopathic Orbital Inflammation

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