Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted?

Kuru, Oğuzhan; Boyraz, Gökhan; Uçkan, Hasan; Erturk, Anil; Gültekin, Murat; Özgül, Nejat; Salman, Coskun; Yüce, K.

doi:10.1016/j.ejogrb.2017.10.010

Cited by 13 publications

(13 citation statements)

References 16 publications

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“…1,8 GHT görülen insanlarda retroperitoneal lenf yumrularına, köpeklerde karaciğere, kısrakta abdominal lenf yumrularına, böbreklere ve adrenal bezlere metastaz şekillendiği bildirilmiştir. [8][9][10] GHT olgularında etkilenmiş olan ovaryum, normalden çok daha büyük ve multilobuler yapıda olup, periferal veya fokal kistik alanlara sahiptir. 11 Tedavi olarak cerrahi müdahale ile tümörlü ovaryumun uzaklaştırılması sayesinde, hipofizer fonksiyonun yan etkilerinin kaldırılarak, foliküler gelişim ve ovülasyonun sürdürülmesi sağlanmaktadır.…”

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A Case of Granulosa Cell Tumor in an Arabian Mare

Kurban¹,

Uçmak²,

Gündüz³

et al. 2019

Turkiye Klinikleri J Vet Sci

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varyan neoplazmlar; yüzey epitelyal tümörler, germ hücre tümörleri ve seks kord gonadal stromal tümörler olmak üzere üç kategoride incelenmektedirler. 1 Seks kord gonadal stormal tümörler ise granüloza hücre tümörü (GHT), tekoma ve luteoma olmak üzere kendi içinde üçe ayrılmaktadır. 2 GHT, kısraklarda en yaygın görülen seks kord stromal tümör tipidir. 1 Kısraklardaki tüm tümöral vakaların %2,5'ini genital kanal tümörlerinin %85'ini oluşturmaktadır. 3,4 Kısraklarda GHT bakımından belirgin bir ırk yatkınlığının olmadığı, GHT görülme yaşının 2-20 yıl arasında değiştiği (ortalama 10,6 yıl) bildirilmiştir. 5 Bu kısraklar üç farklı

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A Case of Granulosa Cell Tumor in an Arabian Mare

Kurban¹,

Uçmak²,

Gündüz³

et al. 2019

Turkiye Klinikleri J Vet Sci

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“…Adult granulosa cell tumor of the ovary is a malignant sex‐cord stromal tumor, however, it shows favorable outcomes due to early diagnosis of the disease. Accordingly disease‐related deaths is reported to be very rare with an approximately 90% rate of 5‐year OS . Tumor‐related death is commonly associated with recurrence; hence recurrence‐free survival was considered as the main outcome to be investigated in this study.…”

Section: Discussionmentioning

confidence: 99%

“…However, their median number of removed lymph nodes was 43, which was notably higher than previous reports. Although, the authors did not evaluate the impact of lymphadenectomy on survival and recurrence, based on the rarity of lymph node involvement researchers suggested that lymphadenectomy may be omitted in patients with AGCT . The optimal number of lymph node count during epithelial ovarian cancer surgery was found to be 15 for pelvic lymph nodes and 7 for paraaortic lymph nodes .…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly disease-related deaths is reported to be very rare with an approximately 90% rate of 5-year OS. [5][6][7][8] Tumor-related death is commonly associated with recurrence; hence recurrencefree survival was considered as the main outcome to be investigated in this study. Additionally, we investigated the effect of lymphadenectomy on postoperative morbidity, which is another crucial factor to evaluate the efficiency of such a surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

“…In the current literature, there are controversial results regarding lymph node involvement in primary surgery and recurrence. [5][6][7][8][9] Although lymph node involvement was reported to be as high as 8.8% 10 current reports suggested omitting lymphadenectomy. 7 However, all these studies have heterogeneous lymph node count and different survival data.…”

Section: Introductionmentioning

confidence: 99%

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Does lymphadenectomy effect postoperative surgical morbidity and survival in patients with adult granulosa cell tumor of ovary?

Erkılınç¹,

Taylan

Karataşlı³

et al. 2019

J of Obstet and Gynaecol

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Aim To evaluate the effect of lymphadenectomy on surgical morbidity and survival in adult granulosa cell tumor (AGCT) of the ovary. Methods Patients who underwent surgical treatment for AGCT between January 1993 and January 2016 were identified. Data were collected for patient age, menopausal status, surgical staging, lymphadenectomy, postoperative complications (anemia, wound infection, incisional hernia), length of hospital stay, follow‐up duration, site and time for recurrence, management of recurrence and vital status. Histopathological records were also evaluated for number of cellular mitosis. Results Lymphadenectomy (pelvic–paraaortic) was performed in 53 (53%) of 98 patients. Decrease in postoperative hemoglobin level and increased wound infection and longer hospital stay were significantly higher in lymphadenectomy group (P = 0.003, 0.043 and <0.001, respectively). Tumor stage (HR 95% CI 14.9 [2.43–92.8]) and number of mitoses >5 (HR 95% CI 14.9 [2.43–92.8]) were significantly associated with recurrence (P = <0.001 and 0.02, respectively). Tumor stage was the only prognostic factor for predicting overall survival (HR 95% CI 8.47 [2.17–33.2]). Lymphadenectomy showed no effect on disease‐free survival and overall survival both in multivariate Cox regression analyses (P = 0.46 and 0.69, respectively). Disease‐free survival and overall survival were similar in lymphadenectomy and no lymphadenectomy groups (Log Rank P = 0.382, 0.741, respectively). Conclusion Lymphadenectomy had no improved effect on survival and had negative effect on surgical morbidity in patients with AGCT.

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