Retrospective evaluation of the effects of diazepam in dogs with anxiety-related behavior problems

Abstract

Adverse effects of diazepam in dogs were commonly reported and often led to drug discontinuation. Owner education and follow-up is recommended to avoid treatment failure when prescribing diazepam for anxiety-related behavior problems in dogs.

An open-label prospective study of the use of l-theanine (Anxitane) in storm-sensitive client-owned dogs

“…Owner satisfaction and treatment success data. (Crowell-Davis et al, 2003;Cracknell and Mills, 2008;Gruen and Sherman, 2008;Herron et al, 2008;Ibanez and Anzola, 2009;Ogata and Dodman, 2011). One study has shown no statistically significant difference between dogs whose owners interacted with them during a storm and those that did not (Cottam et al, 2013).…”

“…Psychotropic medications including SSRIs Ibanez and Anzola, 2009), serotonin 2A antagonist/reuptake inhibitors (Gruen and Sherman, 2008), TCAs (Crowell-Davis et al, 2003), alpha-2 agonists (Ogata and Dodman, 2011), and benzodiazepines (Crowell-Davis et al, 2003;Herron et al, 2008;Ibanez and Anzola, 2009) have been studied as treatments for noise phobias and other situational anxieties in dogs. However, daily psychotropic medications including SSRIs and TCAs may have possible obstacles to success including a delayed onset of therapeutic effect of up to 4 weeks (Crowell-Davis and Murray, 2006) and the potential need for an additional situational medication (Crowell-Davis et al, 2003;Gruen and Sherman, 2008;Ibanez and Anzola, 2009).…”

“…As a tranquilizing agent, phenothiazines are very dependent on dose to achieve anxiolytic properties, often resulting in a large degree of sedation, which clients may find unacceptable and lead them to discontinue using the prescription. Over time, research data on anxiolytic medications have broadened, giving the veterinary practitioner other more efficacious options, such as tricyclic antidepressants (TCAs) (Crowell-Davis et al, 2003), benzodiazepines (Crowell-Davis et al, 2003;Herron et al, 2008;Ibanez and Anzola, 2009), alpha-2 agonists (Ogata and Dodman, 2011), selective serotonin reuptake inhibitors (SSRIs) (Ibanez and Anzola, 2009), and serotonin 2A antagonist/reuptake inhibitors (Gruen and Sherman, 2008).…”

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

“…Herron et al discussed anxiolytic effects of diazepam through GABA receptors on animal subjects [16]. Taking into account that saffron is traditionally used as anxiolytic medicine and given its effect on lessening anxiety before surgery, the probable cause of such effects are physiologic and biologic effects of the medicine.…”

Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

“…Finally, since the veterinary literature qualitatively cites case studies of accidental GABA-A receptor modulator and antihistamine ingestion causing paradoxical hyperarousal in healthy dogs (Barnett et al, 1984; Bertini et al, 1995; Richardson et al, 2002; Wismer, 2002; Herron et al, 2008; Lancaster et al, 2011), we quantitatively pre-tested several representative drugs via polysomnography (PSG) to determine whether we could evaluate different pharmacological hypnotic mechanisms in the salience gating arousal paradigm.…”