Revisiting the structural homogeneity of NU-1000, a Zr-based metal–organic framework

İslamoğlu, Timur; Otake, Ken‐ichi; Li, Peng; Buru, Cassandra T.; Peters, Aaron W.; Akpınar, Işıl; Garibay, Sergio J.; Farha, Omar K.

doi:10.1039/c8ce00455b

Cited by 156 publications

(221 citation statements)

References 45 publications

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“…For example, planar tetracarboxylates ( Figure 2b) such as tetrakis(4carboxyphenyl)porphyrin (TCPP), when combined with 12-connected hexagonal Zr 6 SBUs gives PCN-223 and with 6-connected Zr 6 SBUs gives PCN-224; in these cases, additives to syntheses tune the formation of the different MOFs [57,58]. Similarly, the structurally related 1,3,6,8(tetrakis(p-benzoate)pyrene ligand, when linked by 8-connected Zr 6 SBUs, leads to both NU-901 and NU-1000 MOFs [59][60][61]. Zr MOFs are robust enough to allow incorporation of multiple related ligands into the same topologythe so-called mixed linker approachand also doping of alternative metal cations in place of the Zr 4+ units.…”

Section: Structures and Syntheses Of Zirconium Mofsmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

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Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

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Section: Structures and Syntheses Of Zirconium Mofsmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

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“…NDC incorporation via SALI, Mo(VI) oxide deposition and the subsequent reduction to (IV), and sulfidation were performed on the parent framework, NU‐1000, according to the reported procedures . The resulting material, MoS x ‐SIM‐NDC‐SALI , retained its porosity after the above treatments, as evident from the N 2 adsorption‐desorption isotherm performed at 77 K; see Figure a.…”

Section: Resultsmentioning

confidence: 99%

“…All MOF‐based samples were synthesized according to reported procedures . Electrode fabrication is analogous to that reported previously .…”

Section: Methodsmentioning

confidence: 99%

Single‐Site, Single‐Metal‐Atom, Heterogeneous Electrocatalyst: Metal–Organic‐Framework Supported Molybdenum Sulfide for Redox Mediator‐Assisted Hydrogen Evolution Reaction

et al. 2020

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Synthesis of single-site catalysts, whereby the local structure and surrounding chemical environments are identical, has been challenging, particularly in heterogeneous catalysis, as the support often presents spectrum of chemically distinct binding sites. Yet, the above criteria are crucial in attributing the apparent catalytic performance to the structural motif. The presented work augments on our previous work using monometallic molybdenum sulfide tethered within a zirconium-based metal-organic framework (MOF), NU-1000; the monometallic nature enables all presented sites to be catalytically addressable. As the molybdenum sulfide species resided within two distinct pores (micro-and mesopores) of the MOF support, we have imparted uniformity in the local chemical environment by reducing the pore heterogeneity down to a single mesopore. Single-site and single-atom nature of the candidate catalyst was established via X-ray diffraction measurements. Redox mediators were implemented, which, under reductive potentials, provide reduced species; they can effectively deliver the necessary reducing equivalences to the catalytic units that can otherwise not be addressed electrochemically due to the low electron mobility within the framework. Our results indicate the micropore-allocated molybdenum sulfide is approximately four times more active as that in mesopores, whereas its catalytic mechanism is identical, underscoring the importance of controlling chemical environment beyond the active site.

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“…Examination of the literature reveals that frameworks featuring confined ceramic nodes (e.g. the UiO- 21,22 and NUseries, 23 and other Zr6(O)4(OH)4 containing frameworks) boast improved chemical stability over their late transition metal analogues. [21][22][23][24][25] Zrbased frameworks are known, however, to be primarily electrically insulating even with the inclusion of electroactive guests into the pores.…”

mentioning

confidence: 99%

“…the UiO- 21,22 and NUseries, 23 and other Zr6(O)4(OH)4 containing frameworks) boast improved chemical stability over their late transition metal analogues. [21][22][23][24][25] Zrbased frameworks are known, however, to be primarily electrically insulating even with the inclusion of electroactive guests into the pores. 26,27 Inspired by both the pursuit of a chemically stable and redox active scaffold, we aimed to synthesize novel Zr-based frameworks composed of redox active linkers.…”

mentioning

confidence: 99%

Toward New 2D Zirconium-Based Metal–Organic Frameworks: Synthesis, Structures, and Electronic Properties

et al. 2019

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Nowadays, zirconium metal–organic frameworks attract more attention because of their robustness and their easier predictability in terms of topology. Herein, we have been able to control synthetic parameters in order to construct two new 2D MOFs with the same sql topology. Both materials, ACM-10 and ACM-11, have been characterized by single-crystal X-ray diffraction, thermogravimetric analysis, and UV–vis spectroscopy. Their textural, electrochemical, and conductivity properties are presented along with the opportunities that these new topologically interesting scaffolds offer for the design of new structures.

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Revisiting the structural homogeneity of NU-1000, a Zr-based metal–organic framework

Abstract: Synthesis and activation of phase-pure and defect-free metal–organic frameworks (MOFs) are essential for establishing accurate structure–property relationships.

Cited by 156 publications

References 45 publications

Application of zirconium MOFs in drug delivery and biomedicine

Application of zirconium MOFs in drug delivery and biomedicine

Single‐Site, Single‐Metal‐Atom, Heterogeneous Electrocatalyst: Metal–Organic‐Framework Supported Molybdenum Sulfide for Redox Mediator‐Assisted Hydrogen Evolution Reaction

Toward New 2D Zirconium-Based Metal–Organic Frameworks: Synthesis, Structures, and Electronic Properties

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