Risk Factors for Antisperm Antibodies in Infertile Men

Heidenreich, Axel; Bonfig, Roland; Wilbert, D. M.; Strohmaier, W. L.; Engelmann, U.

doi:10.1111/j.1600-0897.1994.tb00849.x

Cited by 122 publications

(79 citation statements)

References 44 publications

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“…This is probably a rejection mechanism, since the presence of antisperm antibodies has been associated with impaired fertility. Heidenreich et al [21] have demonstrated that the prevalence of antisperm antibodies in the general population is 0-5%, and a higher prevalence in infertile men at 7-26%. The main hypothesis of the present study was that ABO blood group status and combination between spouses may be a factor in the expression of circulating antisperm antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…The factors that promote the production of antisperm antibodies include infection [2], trauma and smoking [12,21]. We have recently reported an association between antisperm antibody production and HLA haplotypes DR4, DR6, and DQw3 in women and DR6 and DQ7 in men, and homozygosity of DR4, DR6, and DQ7 was more common in couples with antisperm antibodies but deficient in DQw3 [22].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

ABO Blood Group and Expression of Antisperm Antibodies in Infertile Couples in Kuwait

Omu

Al-Mutawa²,

Al-Qattan³

1998

Gynecol Obstet Invest

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Two hundred and fifty infertile couples and 102 fertile controls were evaluated to determine the association between ABO blood group status and seminal blood group substances among infertile couples and expression of circulating antisperm antibodies. Antisperm antibodies occurred in 18.8 and 17.7% of the infertile men and women, compared to 3.9% in the fertile women (p < 0.01). The 23 ABO blood group combinations in the infertile and fertile couples revealed no significant association with infertility except the predominance of B+/O+ spouses in the fertile group (p < 0.03). Although 76.8% of the men were secretors of seminal blood group substances, there was no significant association with development of antisperm antibodies. This shows that ABO blood group is not directly associated with infertility nor antisperm antibody formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

ABO Blood Group and Expression of Antisperm Antibodies in Infertile Couples in Kuwait

Omu

Al-Mutawa²,

Al-Qattan³

1998

Gynecol Obstet Invest

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“…However ASA may also be present in both fertile men and women [14,15]. This indicates that not all ASA cause infertility and their role in reproduction remains questionable.…”

Section: Introductionmentioning

confidence: 99%

Increased Level of Antibodies Cross-Reacting with Ves v 5 and CRISP-2 in MAR-Positive Patients

Brunner-Agten

Pavlovic

Müller

et al. 2012

Int Arch Allergy Immunol

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Background: Anti-sperm antibodies (ASA) have been described to be involved in immunological infertility. A possible antigen for ASA is the human cysteine-rich secretory protein 2 (CRISP-2), a sperm surface protein important in sperm-oocyte interaction. Furthermore, anti-CRISP-2 antibodies were shown to decrease fertility rates in vitro. Recently, we have reported cross-reacting antibodies recognizing CRISP-2 and antigen 5 from yellow jacket venom (Ves v 5) in human serum. Methods: Here, we investigated anti-Ves v 5 and CRISP-2 antibodies in sera from two groups of donors: MAR+ and MAR– patients. Results: A higher incidence of allergy against hymenoptera venom was found in MAR+ patients. Interestingly, affinity-purified ASA from MAR+ patients’ sera reacted against both Ves v 5 and CRISP-2, leading to sperm immobilization. Immunofluorescence analysis showed that ASA bound to the sperm surface, including the head part where CRISP-2 is localized. Conclusion: Taken together, these results showed a higher incidence of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR+ patients. This leads to the hypothesis that MAR+ patients may have a higher risk to develop wasp allergy.

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“…Among the risk factors for ASA production, the chronic inflammatory diseases with different localization are believed to play an important role [5][6][7][8]. The inflammatory response is associated with production of antibodies to spermatozoal and microbial antigens.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to investigate the possible association between serum anti-Helicobacter pylori antibodies and anti-sperm antibodies (ASA) in patients with gastroduodenal diseases caused by H. pylori, infertile patients positive for ASA and healthy fertile blood donors as controls. Serum ASA were studied by sperm agglutination tests, sperm immobilization test and ELISA against sperm antigens (ELISAsp). Serum IgG anti-H. pylori antibodies were detected by ELISA (ELISAHp). The tests revealed significantly higher incidence of ASA in patients with gastroduodenal diseases compared to the controls (P < 0.0001). The median levels of both types of antibodies were significantly higher in infertile patients than in patients with upper gastroduodenal diseases in all tests applied (sperm agglutination and immobilization tests P < 0.0001; ELISAsp P D 0.006; ELISAHp, P D 0.0008). Significant linear correlation was found between anti-H. pylori antibodies and ASA detected by sperm immobilization test (r D 0.613, P D 0.05) in the group of patients with gastroduodenal disease, as well as a weak linear correlation was established between anti-H. pylori antibodies and ASA in ELISAsp (r D 0.275, P D 0.0051) in the same group. These results suggest that H. pylori infection may play a role in the induction of ASA.

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Risk Factors for Antisperm Antibodies in Infertile Men

Cited by 122 publications

References 44 publications

ABO Blood Group and Expression of Antisperm Antibodies in Infertile Couples in Kuwait

ABO Blood Group and Expression of Antisperm Antibodies in Infertile Couples in Kuwait

Increased Level of Antibodies Cross-Reacting with Ves v 5 and CRISP-2 in MAR-Positive Patients

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

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