Role of allopurinol and febuxostat in the amelioration of dextran-induced colitis in rats

El-Mahdy, Nageh Ahmed; Saleh, Dina Ali; Amer, Magdy; Abu-Risha, Sally El-Sayed

doi:10.1016/j.ejps.2019.105116

Cited by 13 publications

(9 citation statements)

References 47 publications

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“…However, febuxostat lowered the TNF-α serum level. This outcome corresponds with different studies that disclosed a potential effect of febuxostat in reducing proinflammatory cytokines (El-mahdy et al, 2020;Ahmed et al, 2021). Likewise, BNP was significantly increased with DOX treatment.…”

Section: Discussionsupporting

confidence: 89%

“…The focus on xanthine oxidase inhibitors has increased due to their anti-inflammatory, antioxidant, and immune-modulatory effects, which might be beneficial in the treatment of different inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and ulcerative colitis ( El-Mahdy et al, 2020 ) and thus, it may be beneficial in alleviating oxidative stress and inflammation associated with DOX-induced cardiotoxicity. Therefore, the present study aimed to evaluate the possible cardioprotective effects of P. ginseng and febuxostat alone or in combination against DOX-induced cardiotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Al-Kuraishy

Al-Hussaniy²,

Al-Gareeb

et al. 2022

Front. Pharmacol.

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Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of P. ginseng C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity. Thirty-five Sprague Dawley male rats were used in this study. The animals were randomly divided into five groups, with seven rats per group. The control group received normal saline, the induced group received DOX only, and the treated group received P. ginseng, febuxostat, and their combination before DOX treatment. Biomarkers of acute cardiac toxicity were assessed in each group. Results showed that treatment with the combination of febuxostat and P. ginseng before DOX led to a significant improvement in the biomarkers of acute DOX-induced cardiotoxicity. In conclusion, the combination of P. ginseng and febuxostat produced more significant cardioprotective effects against DOX-induced cardiotoxicity when compared to either P. ginseng or febuxostat when used alone. The potential mechanism of this combination was mainly mediated by the anti-inflammatory and antioxidant effects of P. ginseng and febuxostat.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Al-Kuraishy

Al-Hussaniy²,

Al-Gareeb

et al. 2022

Front. Pharmacol.

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“…Similarly, Qiao et al showed that JWSYD effectively treated DSS-induced UC by inhibiting the NLRP3 inflammasome and NFκB pathway (Qiao et al, 2020). Another study also reported the beneficial effects of xanthine oxidase inhibitors in the treatment of DSS-induced UC in rats via inhibition of IL-1β and IL-18 (El-Mahdy et al, 2020). Moreover, Cheng et al stated that isoorientin; a C-glycosylflavone showed a promising effect in the treatment of trinitrobenzene sulfonic acid-induced bowel disease through the amelioration of NLRP3 (Cheng et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Protective effect ofMorus macrouraMiq. fruit extract against acetic acid-induced ulcerative colitis in rats: Involvement of miRNA-223 and TNFα/NFκB/NLRP3 inflammatory pathway

Salama

Darwish

Shaffei

et al. 2020

Preprint

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Tumor necrosis factor receptor (TNFR) activation and nuclear factor kappa B (NFκB) expression play a significant role in the activation of nod-like receptor pyrin domain-1 containing 3 (NLRP3) inflammasome inflammatory pathway, which is involved in the pathogenesis of ulcerative colitis (UC). Furthermore, miRNA-223 expression was shown to exert counter-regulatory effect on NLRP3 expression. Interestingly, polyphenols are attaining increased importance for their potential effectiveness in ameliorating certain diseases owing to their antioxidant and anti-inflammatory activity. In accord, our study attempted to investigate the effect of mulberry tree (Morus macroura) fruit extract (MFE) against acetic acid (AA)- induced UC in rats, which is not previously investigated, based on previous promising results for MFE in alleviating gastric ulcer in rats. First, total phenolic (TPC), total flavonoid (TFC), and total anthocyanin content (TAC) were determined in MFE. Then, MFE (300 mg/kg) and sulfasalazine (Sulfa), as a standard treatment (100 mg/kg), were given orally for seven days before intra-rectal induction of UC by AA (2 ml, 4% v/v) on day eight. The extent of UC was evaluated macroscopically and microscopically. Biochemically, the colonic TNFR1, NLRP3, p- NFκB p65, TNFα, interleukin-1 beta (IL-1β), IL-18 levels, miRNA-223 expression and caspase-1 activity were assayed. MFE significantly reduced macroscopic and microscopic scores, colonic levels of TNFR1, NLRP3, p-NFκB p65, TNFα, IL-1β, IL-18, and caspase-1 activity, and showed increased miRNA-223 expression, almost similarly to Sulfa effects. In conclusion, our study provided a novel impact for MFE against AA-induced UC in rats through affecting miRNA-223 expression and halting TNFα/NFκB/NLRP3 inflammatory pathway.

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“…11 IL-6 increase was consistently observed in COVID-19 cases in Wuhan, China. 13 Increase in IL-6 level indicates a simultaneous increase in XO activity 20,21 ; this is confirmed by increased plasma uric acid levels in patients with ARDS. 22,23 An experimental study on mice by Fonseca et al 24 showed that respiratory syncytial virus (RSV) infection increased XO expression on days 2-8 post-infection.…”

Section: The Possible Role Of Xo In Sars-cov-2 Infection Pathogenesismentioning

confidence: 79%

Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management

et al. 2020

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The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.

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Role of allopurinol and febuxostat in the amelioration of dextran-induced colitis in rats

Cited by 13 publications

References 47 publications

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Protective effect ofMorus macrouraMiq. fruit extract against acetic acid-induced ulcerative colitis in rats: Involvement of miRNA-223 and TNFα/NFκB/NLRP3 inflammatory pathway

Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management

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