Role of AMH in Prediction of Menopause

Kat, Annelien C de; Broekmans, Frank J.; Lambalk, Cornelis B.

doi:10.3389/fendo.2021.733731

Cited by 25 publications

(20 citation statements)

References 38 publications

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“…Chemotherapy damages follicular cells (granulosa and theca cells), causing a continued decline in female steroid secretion and a disorder of female endocrine balance. AMH, secreted by antral and preantral follicular granulosa cells, re ects ovarian function and reserve [33] . Its level is less affected by pregnancy, oral contraceptives, and female physiological cycles, and its decline may indicate a decrease in ovarian follicular cistern reserve.…”

Section: Discussionmentioning

confidence: 99%

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

Ling

Dai

et al. 2023

Preprint

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As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying ovarian aging by replenishing the primordial follicle pool. Therefore, activating FGSCs is critical in reshaping and safeguarding ovarian function. In this study, we investigated the biological activity of proanthocyanidins (PACs), natural antioxidants that exhibit anti-aging and anti-inflammatory properties beneficial for both male and female reproduction. Our in vivo and in vitro experiments demonstrate that PACs promote FGSCs proliferation while delaying ovarian aging. Specifically, PACs increase the number of primordial follicles, primary follicles, corpus luteum while reducing cystic follicles, and elevate estradiol(E2) levels along with anti-mullerian hormone(AMH) concentration levels in mice. Additionally, PACs significantly boost FGSC proliferation time- and dose-dependently by upregulating mRNA & protein expressions for FGSC-specific markers such as Mvh and Oct-4 while downregulating p53/p21 via activation of Sirt1 signaling pathway. The effects of PACS on FGCS were found to be impeded by the Sirt1 inhibitor EX527.Overall, this research provides strong evidence suggesting that PACS delay premature ovarian failure through regulating the Sirt1-p53-p21 signaling pathway involving female germline stem cells.

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Section: Discussionmentioning

confidence: 99%

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

Ling

Dai

et al. 2023

Preprint

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“…However, some sources believe that the AMH is not a precise measure of overall ovarian aging. De Kat et al confirm that although the AMH and other ovarian reserve markers are definitely related to age at the time of menopause, they insufficiently inform the exact trajectory of an individual’s ovarian aging cycle [ 39 ]. In their prospective cohort study, Depmann et al found that although the AMH was a significant predictor of time until menopause or TTM and time until early menopause, they found that individual predictions of age at which menopause begins had limited precision [ 40 ].…”

Section: Menopausementioning

confidence: 99%

Clinical Utilities of Anti-Müllerian Hormone

Russell

Gilmore

Roudebush

2022

JCM

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The anti-Müllerian hormone (AMH) plays an essential role in sex determination in early embryonic development. Through a series of sequential steps that follows inheriting an XY chromosome, Sertoli cell differentiation upregulates the expression of AMH-suppressing Müllerian duct development and maintains the AMH at a high level until puberty. In females, the AMH is produced by granulosa cells of follicles beginning in the second half of fetal life and continues through adulthood, with a steady decline through the reproductive years and severe decline at menopause, until levels eventually become undetectable. The AMH is essential for the regulation of follicular maturation via the recruitment of primordial follicles throughout folliculogenesis. AMH serum concentration in women strongly correlates with ovarian reserve quantity and reflects ovulation potential. Because the AMH is expressed almost exclusively by growing follicles before FSH-dependent selection, it commonly serves as a marker for ovarian function in various clinical situations, including in the diagnosis and pathogenesis of polycystic ovarian syndrome, artificial reproductive technology, and predictions of menopause or premature ovarian failure.

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“…Serum AMH levels remain relatively stable during the menstrual cycle, 11 reflecting the ovarian reserve 12 and decline towards menopause. 13 …”

Section: Hypogonadism In the Paediatric Age Group: Differences From H...mentioning

confidence: 99%

“…8-10. Serum AMH levels remain relatively stable during the menstrual cycle, 11 reflecting the ovarian reserve 12 and decline towards menopause. 13 The newborn shows very low levels of gonadotropins and ovarian hormones at birth, 14 and a subsequent increase with one or two peaks during the first year of life. 15,16 This active period of the female HPG axis declines after 1 year of age, when serum LH and oestrogens become undetectable, and serum FSH and inhibin B are detectable but low.…”

mentioning

confidence: 99%

Review of the Function of the Hypothalamic–Pituitary–Gonadal Axis in Children and Adolescents with Cancer

Dacal¹,

Grinspon²,

Rey³

2022

European Endocrinology

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The most common malignancies in childhood are leukaemias, brain tumours, lymphomas, neuroblastomas, soft tissue sarcomas and kidney tumours. At present, about 80% of childhood cancers can be treated successfully, which has significantly increased long-term survival. Concomitantly, adult gonadal function in childhood cancer survivors has become a concern. However, the immediate effect of cancer and its management on the reproductive axis function has received less attention. We conducted a review of the effects of malignancies and their treatments on the gonadal axis during childhood and adolescence. Some results are controversial, probably because the analyses do not distinguish between the malignancy types, their treatments and/or the age at treatment. However, there is agreement that cancer can partially affect gonadal function before treatment, as revealed by low circulating levels of inhibin B and anti-Müllerian hormone. Subsequently, chemotherapy transiently impairs the somatic component of the gonads (i.e. testicular Sertoli cells and ovarian granulosa cells) with normalization after treatment ends. The impact of chemotherapy may persist through adulthood after more intensive chemotherapy regimens, radiotherapy and conditioning for haematopoietic stem cell transplantation, when there is a severe impairment of the somatic component of the gonads or of the stem germ cells.

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Role of AMH in Prediction of Menopause

Cited by 25 publications

References 38 publications

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

The role of Procyanidins in delaying the Premature Ovarian Insufficiency through regulatory Sirt1-p53-p21 signaling Pathway in Female Germline Stem Cells

Clinical Utilities of Anti-Müllerian Hormone

Review of the Function of the Hypothalamic–Pituitary–Gonadal Axis in Children and Adolescents with Cancer

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