Role of Common bla _{OXA-24/OXA-40} -Carrying Platforms and Plasmids in the Spread of OXA-24/OXA-40 among Acinetobacter Species Clinical Isolates

Emergence of OXA-72-producing Acinetobacter pittii clinical isolates

“…Shotgun DNA cloning was then performed to identify the genetic structure surrounding the bla OXA-72 gene. It revealed very similar structures to those identified on the GR12 plasmid-type and bla OXA-72 -positive plasmid pMMD identified in a clinical isolate of A. baumannii from Spain [5]. Altogether, these data indicated that these three plasmids, although originating from different strains, were likely the same.…”

Outbreak Caused byblaOXA-72-ProducingAcinetobacter baumanniiST417 Detected in Clinical and Environmental Isolates

“…14 Indeed, plasmids with the bla OXA-24/40-like gene integrated into different locations, flanked by XerC/ XerD-like binding sites, have been recently reported in A. baumannii strains from Spain, Italy, Portugal, the United States, and Colombia. 1,6,9,14,24 The bla OXA-72 gene described in these imipenem-resistant A. baumannii isolates corresponded to plasmid-borne genes and was flanked by XerC/ XerD recombination sites. The sequence analysis of regions surrounding the bla OXA-72 gene showed that they presented 100% identities with DNA sequences in the pAB120 (NC_ 019359) and pAC92 (NG_041527) plasmids.…”

Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: the Klebsiella pneumoniae Paradigm

“…The function of this site, at least in some plasmids, is to maximize stabilization by mediating resolution of multimers, a process that leads to a reduction in the effective number of molecules and results in segregational loss of the plasmid (83-87). Other plasmid-related functions of these sites may include exchange of DNA regions among plasmids (54, 88) as well as mediating the insertion of integrative mobile elements into chromosomes and plasmids (83, 89, 90). …”