Role of Flavonoids in Management of Inflammatory Disorders

Shukla, Rajesh; Pandey, Vikas; Vadnere, Gautam P.; Lodhi, Santram

doi:10.1016/b978-0-12-813820-5.00018-0

Cited by 79 publications

(57 citation statements)

References 127 publications

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“…The efficacy of AERDP was 61% at 2 h (p<0.01), evidencing a pronounced anti-inflammatory activity. Our results correlate with literary data [44], [45], [46], [47], [42], [43], thus confirming the anti-inflammatory potential of aqueous hyperoside-containing extracts.…”

Section: Carrageenan Oedema Assaysupporting

confidence: 89%

Pharmacognostic, phytochemical and pharmacological aspects of Rosa x damascena Herrm. Georgian cultivar

Aleksidze¹,

Mchedlidze²,

Getia³

et al. 2021

GSC Biol. and Pharm. Sci.

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Rosa x damascena Herrm. represents one of the most popular and important plants of the Rosaceae family. For ages, rose oil, rose water and extracts from its flowers were used in perfumery, cosmetics, aromatherapy, and medicine due to diverse pharmacological efficacy. Nowadays, special attention is paid to the valorization of wastes from the rose oil industry in order to fully recover potent biologically active compounds. The present study describes in detail the microstructural features of the flower petals and provides data on chemical composition and biological potency of the aqueous extract of rose oil waste from the R. damascena Georgian cultivar. Up to 25 constituents were detected by HPLC-MS in the extract, and the content of total flavonoids in the extract reaches 2.29%. Amongst them hyperoside is dominating, which content is not less than 1%. Pharmacological evaluation of the extract on "Hot plate" and carrageenan-induced oedema models in mice revealed analgesic (42%) and anti-inflammatory (67%) effects of the extract. As well, the extract revealed antiplasmodial activity against Plasmodium falciparum (3D7) strain (IC50 =20.31 µg/mL)

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Section: Carrageenan Oedema Assaysupporting

confidence: 89%

Pharmacognostic, phytochemical and pharmacological aspects of Rosa x damascena Herrm. Georgian cultivar

Aleksidze¹,

Mchedlidze²,

Getia³

et al. 2021

GSC Biol. and Pharm. Sci.

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“…The prediction of protein functioning based on mere molecular docking in case of small molecules is difficult. Eriodictyol, bitter taste masker and is known to have anti-inflammatory, antioxidant, cytotoxic, antidiabetic properties ( Shukla et al, 2019 ; Rossato et al, 2011 ; Habtemariam and Dagne, 2009 ; Zhang et al, 2012 ) It is reported to suppress the lipopolysaccharide (LPS)-induced inflammatory responses in macrophages by reducing nitric oxygen, pro-inflammatory cytokines in Raw 264.7 cells ( Lee, 2011 ). Zhu et al had reported anti-inflammatory action of it against LPS induced acute lung injury ( Zhu et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2

Deshpande¹,

Tiwari

Nyayanit³

et al. 2020

European Journal of Pharmacology

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SARS-CoV-2 has devastated the world with its rapid spread and fatality. The researchers across the globe are struggling hard to search a drug to treat this infection. Understanding the time constraint, the best approach is to study clinically approved drugs for control of this deadly pandemic of COVID 19. The repurposing of such drugs can be supported with the study of molecular interactions to enhance the possibility of application. The present work is a molecular docking study of proteins responsible for viral propagation namely 3Clpro, Nsp10/16, Spike protein, SARS protein receptor binding domain, Nsp 9 viral single strand binding protein and viral helicase. The protein through virus enters the host cell-human angiotensin-converting enzyme 2 (ACE2) receptor, is also used as a target for molecular docking. The docking was done with most discussed drugs for SARS-CoV-2 like Ritonavir, Lopinavir, Remdesivir, Chloroquine, Hydroxychloroquine (HCQ), routine antiviral drugs like Oseltamivir and Ribavirin. In addition, small molecules with anti-inflammatory actions like Mycophenolic acid (MPA), Pemirolast, Isoniazid and Eriodictyol were also tested. The generated data confirms the potential of Ritonavir, Lopinavir and Remdesivir as a therapeutic candidate against SARS-CoV-2. It is observed that Eriodictyol binds to almost all selected target proteins with good binding energy, suggesting its importance in treatment of COVID 19. Molecular interactions of Ritonavir, Lopinavir and Remdesivir against SARS-CoV-2 proteins enhanced their potential as a candidate drug for treatment of COVID-19. Eriodictyol had emerged as a new repurposing drug that can be used in COVID-19.

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“…Among the compounds, luteolin and apigenin and several of their derivatives could be identified. Indeed, apigenin has been reported to possess various beneficial health effects such as antioxidant, anti-inflammatory, and chemopreventive effects [36]. Similarly, luteolin and its glycosides are widely distributed in the plant kingdom and preclinical studies have demonstrated this flavone to exhibit a range of pharmacological actions, including antimicrobial, anticancer, antioxidant and anti-inflammatory [37].…”

Section: Resultsmentioning

confidence: 99%

Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals

et al. 2020

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In the present study, Passiflora foetida extracts characterized by different polarities were studied for their phytochemical profile, enzyme inhibitory, and antioxidant potentials. In silico, in vitro and ex vivo studies were also carried out on methanol and water extracts for predicting pharmacokinetics and pharmacodynamics. In this regard, neuronal HypoE22 cells, isolated mouse skin tissues, and pathogen dermatophytes strains were exposed to extracts. Emphasis was given to the preventing effects induced by the extracts on hydrogen peroxide-induced alterations of prostaglandin E2 (PGE2), l-dopa, and serotonin. Chemical analysis revealed the presence of similar compounds in infusion and methanolic extracts. The ex vivo studies also showed protective skin properties by P. foetida water and methanol extracts, as evidenced by the decrease of hydrogen peroxide-induced PGE2 level. Additionally, the blunting effects on hydrogen peroxide-induced l-dopa levels are consistent with the anti-tyrosinase effect exerted by both extracts. In silico studies demonstrated the affinity of extracts’ phytochemicals, namely apigenin, chrysoeriol, loliolide, luteolin, quercetin, and vitexin, towards cyclo-oxygenase-2 and tyrosinase. Finally, microbiological tests demonstrated the efficacy of P. foetida methanol and water extracts as anti-mycotic agents against Trichophyton and Arthroderma species, involved in skin inflammation. Hence, P. foetida L. extracts could represent potential sources of pharmaceuticals and nutraceuticals.

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Role of Flavonoids in Management of Inflammatory Disorders

Cited by 79 publications

References 127 publications

Pharmacognostic, phytochemical and pharmacological aspects of Rosa x damascena Herrm. Georgian cultivar

Pharmacognostic, phytochemical and pharmacological aspects of Rosa x damascena Herrm. Georgian cultivar

In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2

Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals

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