2021
DOI: 10.1016/j.atherosclerosis.2020.11.002
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Role of mechanical stress and neutrophils in the pathogenesis of plaque erosion

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Cited by 32 publications
(8 citation statements)
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“…Many studies [ 10 , 11 ] have shown that mechanical stress plays a key role in regulating bone remodeling and bone homeostasis through mechanical signal transduction pathways. The stress-strain effect first causes changes in the cytoskeletal structure of the cell and subsequently activates a variety of cell biological processes within the osteoblast, such as cell metabolism, gene activation, and secretion of cytokines.…”
Section: Prefacementioning
confidence: 99%
“…Many studies [ 10 , 11 ] have shown that mechanical stress plays a key role in regulating bone remodeling and bone homeostasis through mechanical signal transduction pathways. The stress-strain effect first causes changes in the cytoskeletal structure of the cell and subsequently activates a variety of cell biological processes within the osteoblast, such as cell metabolism, gene activation, and secretion of cytokines.…”
Section: Prefacementioning
confidence: 99%
“…Essa tensão de cisalhamento depende de fatores de turbilhonamento de fluxo que, em regime pulsátil, geralmente são atreladas às variáveis conhecidas como número de Reynolds e número de Womersley 23 . Em 2013, Campbell e colaboradores foram considerados os primeiros a correlacionar a mecânica dos fluidos com as erosões de placas 24,25 .…”
Section: Métodos Propostos Para Investigação Do Quadro Coronarianounclassified
“…Plaque erosion is an alternative thrombotic mechanism for lesions with a distinct morphology (few inflammatory leukocytes and little lipids in the cores, and a rich extracellular matrix without a thin, friable fibrous cap). In comparison to plaque rupture, the molecular mechanisms of plaque erosion are much less studied [41].…”
Section: Initiation Of Atherosclerosismentioning
confidence: 99%