Role of mucosal injury in initiating recurrent aphthous stomatitis.

Wray, D. Walter; Graykowski, Edward A.; Notkins, A L

doi:10.1136/bmj.283.6306.1569

Cited by 105 publications

(48 citation statements)

References 6 publications

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“…The percentage obtained in this regard was lower than the one detected by Wray et al 8 (43.3%). On the other hand, only 9.8% of the participants reported episodes of stress associated with the occurrence of aphthae.…”

Section: Discussioncontrasting

confidence: 70%

“…Several factors have been suggested as triggering agents, including local factors, such as local trauma, which is considered an etiological agent of RAS in susceptible patients. 1,7,8 Regarding systemic factors, the infection by H. pylori has been reported as an etiological factor of RAS. 9 The ulcerous colitis and the Crohn's disease have also been associated with the appearance of oral ulcers similar to the ones of RAS.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of recurrent aphthous stomatitis in a young population

Oliveira¹,

Coimbra²,

Mesquita³

et al. 2018

j.rpemd

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Aim: To characterize recurrent aphthous stomatitis in a young population and investigate the association between these lesions and predisposing factors, as well as potential modifications in children's daily routines. Methods:The data was collected by delivering a questionnaire to students attending S. Miguel Primary School, in Vizela, as well as to their parents/guardians. A literature review was conducted, using scientific databases such as PubMed, Cochrane and the Virtual Library of the University of Porto.Results: A common prevalence of aphthous ulcers was found in 53.0% of the sample. Most participants reported a number of lesions between 1 and 5, located in the jugal/labial mucosa, healing within 4 to 7 days. About 46.4% of the participants had a family history of this disease, mainly on the mother's side. About 29.6% of the students associated aphthae with traumatic events in the oral mucosa, while 9.8% associated them with stress. A significant association was found only between the frequency of aphthae and gastrointestinal disorders, and not with other factors. A significant use of topical medications was detected, and the pharmacist was the most consulted healthcare professional. Conclusion

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Section: Discussioncontrasting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Characterization of recurrent aphthous stomatitis in a young population

Oliveira¹,

Coimbra²,

Mesquita³

et al. 2018

j.rpemd

View full text Add to dashboard Cite

show abstract

“…Local trauma is regarded as a causative agent for RAS in susceptible individuals 10,11 . Trauma predisposes to RAS by inducing edema and early cellular inflammation associated with an increased viscosity of the oral submucosal extracellular matrix 12 .…”

Section: Local Factorsmentioning

confidence: 99%

Recurrent aphthous stomatitis

Akintoye

Greenberg

2005

Dental Clinics of North America

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Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

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“…Local, physical trauma may initiate ulcers in susceptible people (Ross et al, 1958;Wray et al, 1981), and RAS is uncommon where mucosal keratinization is present (Sallay and Ban6czy, 1968) or in patients who smoke tobacco (Brookman, 1960;Dorsey, 1964, Shapiro et al, 1970Axell and Henricsson, 1985a).…”

Section: Local Factors Predisposing To Rasmentioning

confidence: 99%