Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

Afrin, Mafruha; Tumulak, Mayjane Jg; Siak, Jay

doi:10.1080/09273948.2019.1655580

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…In addition, papilledema is one of the signs that tend to lead to delayed VKH diagnosis in the absence of other clinical signs [23,24]. OCTcan intuitively detect subretinal fluid [24] and plays an important role in the diagnosis of VKH [25][26][27]. In our study, the proportion of patients with ODS in the FP mode is much higher than that in the other two imaging modes, and the proportion of patients with SRD is lower than that in the other two imaging modes.…”

Section: Discussionmentioning

confidence: 99%

Clinical Comparative Study of Different Fundus Imaging Methods in the Acute Phase of Vogt-Koyanagi-Harada Disease

Tang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. The diversification of follow-up ophthalmic imaging examination methods, and whether there are differences in clinical characteristics of VKH at the acute stage under different images. Our study aims to compare the imaging characteristics of the acute phase of Vogt-Koyanagi-Harada disease (VKH) under different fundus imaging methods to deepen clinical knowledge. Methods. A retrospective case study was performed on fundus images of 62 eyes from 31 patients with acute phase VKH and a disease duration ≤2 months who were treated at Ganzhou People’s Hospital from January 2013 to December 2020. Fundus photography (FP), optical coherence tomography (OCT), and fundus fluorescein angiography (FFA) were performed on all 62 eyes. The fundus presentations were divided into an optic disc swelling (ODS) group, a serous retinal detachment (SRD) group, and a mixed type (MT) group (both ODS and SRD), and the proportions of patients in these groups and the coincidence rate of ODS, SRD, and MT identified by the three fundus imaging modes were determined. Results. The proportion of patients with ODS was highest under FP, and the proportion of patients with MT was highest under OCT. The proportions of patients with ODS and MT in the three fundus imaging modes differed significantly ( P < 0.05 ), while the proportion of patients with SRD did not ( P > 0.05 ). The proportion of patients with subretinal fluid with positive OCT results was significantly higher than those with positive FFA results (81.08% vs. 59.46%) ( P < 0.05 ). Conclusion. Clinically significant positive signs could be obtained for acute VKH under different imaging methods. However, compared with FP and FFA, OCT tomography is more intuitive for the observation of lesions.

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Section: Discussionmentioning

confidence: 99%

Clinical Comparative Study of Different Fundus Imaging Methods in the Acute Phase of Vogt-Koyanagi-Harada Disease

Tang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…4,5 Optical coherence tomography (OCT) is essential in clinical practice for diagnosing VKH disease, longitudinal monitoring, and assessing treatment efficacy. 8,[20][21][22] Recent technological advancements in OCT, particularly enhanced depth imaging (EDI), and swept-source (SS) OCT, have greatly facilitated the evaluation of the chorioretinal characteristics in VKH patients. Notably, OCT findings, such as SRD, 7 choroidal folds, 12,13 and choroidal thickening, 10,21 may suggest the severity of VKH disease.…”

Section: Introductionmentioning

confidence: 99%

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Hirota¹,

Muraoka²,

Kogo³

et al. 2023

OPTH

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Despite the necessity of optical coherence tomography (OCT) for diagnosis and longitudinal monitoring in patients with Vogt-Koyanagi-Harada (VKH) disease, no studies have identified useful OCT markers for predicting recurrence in these patients. Although the precise reason for this remains unclear, one possibility is that infiltration of inflammatory cells into the choroid attenuates the OCT signal, making it difficult to precisely assess the structure of the choroid. Therefore, this study aimed to investigate changes in retinal pigment epithelium (RPE) reflectivity immediately above the choroid in eyes with acute VKH disease, as well as the association between RPE reflectivity and VKH disease recurrence. Patients and Methods: This single-centered retrospective observational study included 20 treatment-naïve patients with acute VKH disease presenting with serous retinal detachment (SRD) in the posterior pole at the initial visit between October 2015 and January 2020, as well as 15 healthy control eyes. All patients were followed up for at least 6 months and received treatment with intravenous methylprednisolone followed by oral administration of prednisolone. Swept-source OCT images through the fovea were used to measure central retinal thickness, central choroidal thickness, and RPE reflectivity. Results: During an observation period of 37.2 ± 30.8 months, recurrence of inflammation was observed in 11 patients (55.0%). Initial visual acuity was worse in patients who developed recurrence than in those who did not (P=0.024). On initial OCT images, RPE reflectivity differed significantly between patients with and without recurrence (1.75 ± 0.42 vs 1.35 ± 0.20; P=0.018), while there were no significant differences in other chorioretinal parameters, such as central retinal thickness and choroidal thickness. Conclusion: RPE reflectivity on OCT images may be useful for predicting the recurrence of inflammation in patients with VKH disease.

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“…RNFL thickness changes, which are generally used in the diagnosis and followup of glaucoma, have been studied in many retinal and systemic diseases (8)(9)(10). RNFL analysis has been evaluated in inflammatory diseases with skin involvement such as Vogt Koyanagi Harada and vitiligo (11,12). As far as we know, no retina examination has been done in CSU.…”

Section: Introductionmentioning

confidence: 99%

“…As far as we know, no retina examination has been done in CSU. Since retinal dysfunction has been reported in patients with an inflammatory disease such as vitiligo, we wanted to analyze RNLF in CSU (12). At the same time, the inflammatory process in CSU can cause an increase in ganglion cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

Zor

Biçer

Yıldız

2022

Journal of Health Sciences and Medicine

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Aim: In this study, we investigated the effects of chronic spontaneous urticaria on the choroid and retinal nerve fiber layer. Material and Method: The patient group consisted of newly diagnosed 54 chronic spontaneous urticaria (CSU ) patient and the control group consisted of 54 healthy volunteer. Choroidal and retinal nerve fiber layer (RNFL) thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 0,5% tropicamide. Results: In the patient group, nasal choroidal thickness (NCT) was 290.11±43.16 μm, subfoveal choroidal thickness (SFCT) was 339.17±37.709 μm, temporal choroidal thickness (TCT) was 296.00±42.859 μm, mean choroidal thickness (MCT) was 308.33±35.923 μm and RNFL thickness was 91.11±7.393 μm. NCT was 248.42±35,742 μm, SFCT 276.56±40.04 μm, TCT 253.69±37.384 μm, MCT 259.50±32,986 μm and RNFL thickness 92.19±8.719 μm in the control group. When we examine the p value, it is seen that both groups are similar to each other in terms of RNFL thickness (p=0.326), while there is a significant thickening in all choroidal regions of patients with CSU, including NCT, SFCT, TCT, MCT (p=0.000, p=0.000, p=0.000, p=0.000, respectively). Conclusion: The choroid is affected in CSU and choroidal thickness can be a noninvasive method that can be used in diagnosis CSU. However, studies of longer disease durations may provide more illuminating information about CSU and choroid and RNFL.

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Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

Cited by 9 publications

References 28 publications

Clinical Comparative Study of Different Fundus Imaging Methods in the Acute Phase of Vogt-Koyanagi-Harada Disease

Clinical Comparative Study of Different Fundus Imaging Methods in the Acute Phase of Vogt-Koyanagi-Harada Disease

Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt–Koyanagi–Harada Disease: A Retrospective Observational Study

Choroidal thickness and retinal nerve fiber layer analysis in chronic spontaneous urticaria

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