Role of selected amino acids on plasma IGF-I concentration in infants

Fleddermann, Manja; Demmelmair, Hans; Grote, Veit; Bidlingmaier, Martin; Grimminger, Peter P.; Bielohuby, Maximilian; Koletzko, Berthold

doi:10.1007/s00394-015-1105-9

Cited by 27 publications

(21 citation statements)

References 45 publications

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“…We found a generally much greater response of insulin than IGF-I to plasma AA and very different relative effects of individual AA ( Fig. 2 ) [34] . We consider this an important mechanism by which the protein quality provided to infants significantly modifies the energetic efficiency of infant formulae for weight and length gain [35] .…”

Section: Metabolic Response To Infant Protein Supply and Impact On Grmentioning

confidence: 72%

Metabolic Regulation of Pre- and Postnatal Growth

Koletzko¹,

Kirchberg²,

Hellmuth³

et al. 2018

Recent Research in Nutrition and Growth

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Growth characteristics during periods of early developmental plasticity are linked with later health outcomes and with disease risks. Infant growth is modulated by genetic and exogenous factors including nutrition. We try to explore their underlying mechanisms using targeted metabolomic profiling of small molecules in biological samples using high-performance liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) to quantify hundreds of molecules in small biosamples, e.g., 50 µL plasma. In the large German LISA birth cohort study, cord blood lysophosphatidylcholines and fatty acids were closely associated with infant birth weight, with a nonsignificant trend towards an association with infant weight gain and later BMI. Studies in infants randomized to different protein intakes in the European CHOP Study show conventional high protein intakes to markedly increase plasma-indispensable amino acids (AA), particularly branched-chain AA (BCAA), while exceeding the infant's capacity of BCAA breakdown, and an increase in the dispensable AA tyrosine previously associated with insulin resistance. In a path model analysis of the relationship of infant plasma AA, growth factors, and infant growth, AA were generally found to induce a stronger response of insulin than IGF-I although effects of individual AA were very different. We conclude that targeted improvement in nutrient supply in pregnancy and infancy may offer large opportunities for promoting desirable child growth patterns and long-term health.

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Section: Metabolic Response To Infant Protein Supply and Impact On Grmentioning

confidence: 72%

Metabolic Regulation of Pre- and Postnatal Growth

Koletzko¹,

Kirchberg²,

Hellmuth³

et al. 2018

Recent Research in Nutrition and Growth

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“…41 In contrast, FF infants are consistently exposed to a protein concentration of 13 to 14 g/L and hence higher protein intake. 42 Protein intake in excess of requirements may drive higher weight gain in the FF infant, as higher concentrations of fasting 43 and postprandial [44][45][46] branched chain amino acids may stimulate increased insulin concentrations and, in turn, increase cellular glucose uptake. 45,47 Second, the higher weight status of FF infants with RWG may be due to the differences in the complementary diet fed to them.…”

Section: Discussionmentioning

confidence: 99%

Impact of early rapid weight gain on odds for overweight at one year differs between breastfed and formula‐fed infants

et al. 2020

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Summary Background Early rapid weight gain (RWG) increases, whereas longer durations of breastfeeding decreases, odds for later obesity. Objectives To determine the independent and interactive effects of early weight gain and diet on infant weight status trajectories and odds for overweight at 1 year. Methods We conducted secondary analysis on data from two longitudinal trials with repeated anthropometric measures. One trial consisted of predominantly or exclusively breastfed (BF, n = 97) infants, whereas the other consisted of exclusively formula‐fed (FF, n = 113) infants. Weight‐for‐length z‐score (WLZ) change from 0.5 to 4.5 months was used to categorize early weight gain as slow (<−0.67; SWG), normal (−0.67 to 0.67; NWG) or rapid (>0.67; RWG). Linear‐mixed effects models were fit to examine the independent effects and interaction of early diet (BF, FF) and weight gain (SWG, NWG, RWG) groups on WLZ trajectories; logistic regression was used to assess odds for overweight at 1 year. Results While similar percentages (41%) of BF and FF infants experienced RWG, we found a significant diet × early weight gain group interaction (P < .001) on weight status. At 1 year, the WLZ of FF infants with RWG (1.57 ± 0.99) was twice that of BF infants with RWG (0.83 ± 0.92). Using BF infants with NWG as the reference group, FF infants with RWG had increased odds [OR: 25.3 (95% CI: 3.21, 199.7)] for overweight at 1 year, whereas BF infants with RWG did not. Conclusions Early diet interacts with early weight gain and influences weight status trajectories and overweight risk at 1 year.

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“…This hypothesis assume that more protein intake is causative for a more rapid weight gain in the first 2 y of life and higher risk of obesity observed in formula-fed than in breastfed children [ 30 , 31 ]. The more rapid weight gain in formula-fed infants might be mediated through an amino acids-induced secretion of insulin and insulin-like growth factor I (IGF-I) [ 32 , 33 ]. Although the protein intake was not determined in the present study due to lack of data on the volume of breast milk, infants fed with higher volumes formula milk were speculated to consume more protein than breast-fed infants because the protein content was higher in formula milk (1.3~1.7 g/100 ml) than in breast milk (1.0 g~1.3 g/100 ml) [ 13 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Early feeding of larger volumes of formula milk is associated with greater body weight or overweight in later infancy

Huang

Zhang

et al. 2018

Nutr J

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BackgroundThe relation between infant feeding and growth has been extensively evaluated, but studies examining the volume of formula milk consumption on infant growth are limited. This study aimed to examine the effects of early feeding of larger volumes of formula on growth and risk of overweight in later infancy.MethodsIn total, 1093 infants were studied prospectively. Milk records collected at 3 mo of age were used to define the following 3 feeding groups: breast milk feeding (BM, no formula), lower-volume formula milk feeding (LFM, <840 ml formula/d), and higher-volume formula milk feeding (HFM, ≥840 ml formula/d). Body weight and length were measured at 3 time points of 3, 6 and 12 mo of age.ResultsThe results showed that the difference in weight and length between the HFM and BM infants was significant at 3 mo of age (P < 0.05) and continued until 12 mo of age (P < 0.001). The adjusted mean changes in weight-for-length z-scores (WLZ) and BMI-for-age z-scores (BAZ) from 3 to 6 mo of age were significantly higher in HFM and LFM group than in BM group. Two-way interactions between feeding practice and age intervals were significant for WLZ changes (P = 0.002) and BAZ changes (P = 0.017). Compared with BM-fed infants, infants fed with HFM had 1.60-fold (95% CI 1.05–2.44) higher odds of greater body weight (1SD < WLZ ≤2 SD) at the age of 6 mo and 1.55-fold (95% CI 1.01–2.37) higher odds of greater body weight and 2.13-fold (95% CI 1.03–4.38) higher odds of overweight (WLZ > 2 SD) at the age of 12 mo.ConclusionFeeding higher volumes of formula in early infancy is associated with greater body weight and overweight in later infancy.

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Role of selected amino acids on plasma IGF-I concentration in infants

Cited by 27 publications

References 45 publications

Metabolic Regulation of Pre- and Postnatal Growth

Metabolic Regulation of Pre- and Postnatal Growth

Impact of early rapid weight gain on odds for overweight at one year differs between breastfed and formula‐fed infants

Early feeding of larger volumes of formula milk is associated with greater body weight or overweight in later infancy

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