Safeguards-by-Design (SBD) is a new approach to the design and construction of nuclear facilities in which nuclear safeguards provisions and features are designed into the facility from the very beginning of the design process. It is a systematic and structured approach for fully integrating international and national safeguards (MC&A), physical protection, and other barriers into the design and construction process for nuclear facilities, while integrating with safety and other project considerations. Because the successful implementation of SBD is primarily a project management and coordination challenge, this report focuses on that aspect.To improve the implementation of nuclear safeguards worldwide, the United States National Nuclear Security Administration's (NNSA's) Office of International Regimes and Agreements (NA-243) commissioned a U.S. DOE National Laboratory project team to study how SBD could be implemented. This is in support of the NNSA Next Generation Safeguards Initiative (NGSI). The long term objective is to promote the global implementation of SBD so that new nuclear facilities will be designed with nuclear safeguards, safety, and physical protection features incorporated into the facility. This will make new nuclear facilities safer, more secure, and more easily safeguarded. In addressing these issues early in the design stage, it will also be more cost effective, by avoiding the costly retrofits to accommodate these requirements after the facility starts up.In 2008, the SBD project team developed a high-level framework for institutionalizing SBD. As a result, the establishment of SBD as a global standard was found to depend on three pillars: 1) Requirements Definition, including the definition of requirements and criteria for successful safeguards performance, 2) Design Processes, including project management and coordination, and 3) Design Toolkit, including the technology and methodology used in the design and assessment of performance against requirements. These in turn were seen as resting on the foundation of Institutionalization, including education, outreach, training, and standardization. Each of these areas is vital to successfully establish SBD as a global standard.The present report continues the work begun in 2008 and focuses on the design and construction process -specifically, project management and coordination. This includes project planning, definition, organization, coordination, scheduling, communication and interaction between the domestic and international safeguards authorities, facility builders, owner/operators, and other stakeholders during the design and construction of a nuclear facility. It further specifies the stages in an ideal nuclear facility design and construction project and identifies: 1) When safeguards design activities take place, 2) When safeguards stakeholders should be involved, 3) The interaction between safeguards requirements, analysis, and decision making relevant to plant design, and 4) The documents for recording this process, analysis, and de...