Salivary glucose and antioxidant defense markers in type II diabetes mellitus

Mussavira, Sayeeda; Dharmalingam, Mala; Sukumaran, Bindhu Omana

doi:10.3906/sag-1306-116

Cited by 34 publications

(29 citation statements)

References 25 publications

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“…Type 2 diabetics had significantly higher USWG/RCBG levels than the controls, a fact which has been documented in previous studies. [513141516171819] The correlation between RCBG and UWSG could plausibly be because of leakage of glucose from blood across the basement membrane of salivary glands. Microvascular alterations in the blood vessels that are commonly seen in type 2 diabetics could also contribute to increased salivary glucose levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation between salivary glucose and blood glucose and the implications of salivary factors on the oral health status in Type 2 diabetes mellitus patients

Puttaswamy

Puttabudhi

Raju

2017

J Int Soc Prevent Communit Dent

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Aims and Objectives:The purpose of this study was to estimate and assess any correlation between random capillary blood glucose (RCBG) and unstimulated whole salivary glucose (UWSG), as well as to estimate various salivary parameters, such as flow rate, pH, buffering capacity, and the influence of these factors on the oral health status in type 2 diabetes mellitus (DM).Materials and Methods:Sixty individuals suffering from type 2 DM and 40 healthy individuals in the age group of 30–60 years were included in the study. RCBG was estimated using glucometer and UWSG was estimated using photocolorimeter. Salivary parameters such as flow rate, pH, and buffering capacity were assessed using GC® Saliva kit. Oral health status was recorded using the Russell's periodontal index (RPI) and the Decayed Missing Filled Teeth (DMFT) index. The Statistical Package for the Social Sciences version 16 was used for statistical analysis.Results:Type 2 diabetics had higher mean values for RCBG levels and UWSG. Type 2 diabetics had low mean salivary flow rate, pH, and buffering capacity. Type 2 diabetics had higher mean values for RPI.Conclusion:Among the salivary factors studied, salivary glucose significantly influenced the periodontal status in Type 2 diabetics.

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Section: Discussionmentioning

confidence: 99%

Correlation between salivary glucose and blood glucose and the implications of salivary factors on the oral health status in Type 2 diabetes mellitus patients

Puttaswamy

Puttabudhi

Raju

2017

J Int Soc Prevent Communit Dent

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“…An increase in salivary glucose (SGlc) beyond the normal levels in Type 2 DM has been reported by many investigators ( 68 ). However there are also contradicting reports where decreased SGlc levels in DM as compared to the controls was observed ( 69 ).…”

Section: Disorder Specific Salivary Biochemical Variationsmentioning

confidence: 93%

Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review

2015

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This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt an interest in evaluating its diagnostic or prognostic utility. Accumulating data over the past two decades indicates towards the possible utility of saliva to monitor overall health, diagnose and treat various oral or systemic disorders and drug monitoring. Advances in saliva based systems biology has also contributed towards identification of several biomarkers, development of diverse salivary diagnostic kits and other sensitive analytical techniques. However, its utilization should be carefully evaluated in relation to standardization of pre-analytical and analytical variables, such as collection and storage methods, analyte circadian variation, sample recovery, prevention of sample contamination and analytical procedures. In spite of all these challenges, there is an escalating evolution of knowledge with the use of this biological matrix.

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“…In this study salivary TAC level was lower in T2DM patients with VD risk compared to T2DM patients without VD risk. In a recent study conducted by Mussavira et al (20) , TAC was decreased in the saliva of T2DM patients in comparison with healthy controls. In regard to TAC level in patients with CVD, several studies had found a significantly lower serum TAC level in patients with CVD (21,22) .…”

Section: Discussionmentioning

confidence: 82%

“…Saliva has a dynamic diagnostic properties aiding in the detection of oral and systemic disease by using the salivary biomarkers (7,8) . The relationship of salivary oxidative stress markers including: TBARS, UA and TAC were studied in relation to T2DM in previous studies (9,10) . In this study the aim is to investigate the risk of VD in T2DM patients through studying salivary TBARS, UA and TAC all together as an indicator of risk for VD.…”

Section: Introductionmentioning

confidence: 99%

Salivary Oxidative Stress Markers in Relation to Vascular Disease Risk of Type Two Diabetes Mellitus

Abbas¹,

El-Samarrai²

2016

JBCD

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Background: Cardiovascular disease (CVD) is an important complication of type 2 diabetes mellitus (T2DM). Oxidative stress plays a major role in the development of CVD. Saliva has a diagnostic properties aiding in the detection of systemic diseases. This study aimed to assess the association between salivary oxidative stress markers and the risk of vascular disease (VD) in T2DM patients. Materials and Methods: One hundred T2DM patients and fifty apparently healthy males were enrolled in this study. Saliva sample was collected for assessment of oxidative stress markers including: lipid peroxidation plasma thiobarbituric acid-reactive substances (TBARS), uric acid (UA) and total antioxidant capacity (TAC) levels. Arterial stiffness index (ASI) was used for the assessment of VD risk. Results: According to ASI, T2DM patients were categorized into two groups: Group A: T2DM patients without VD risk. Group B: T2DM patients with VD risk. The mean values of TBARS and UA of group B showed a statistically highly significant elevation compared to group A and controls (P<0.01). The mean value of TAC of group B showed a statistically highly significant decrease when compared to group A and controls (P<0.01). Conclusion: The increase in salivary TBARS and UA levels and the decrease in the TAC level can be used as an indicator for the increase of risk for VD in T2DM patients.

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Salivary glucose and antioxidant defense markers in type II diabetes mellitus

Cited by 34 publications

References 25 publications

Correlation between salivary glucose and blood glucose and the implications of salivary factors on the oral health status in Type 2 diabetes mellitus patients

Correlation between salivary glucose and blood glucose and the implications of salivary factors on the oral health status in Type 2 diabetes mellitus patients

Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review

Salivary Oxidative Stress Markers in Relation to Vascular Disease Risk of Type Two Diabetes Mellitus

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