Salivary MMP‐8, TIMP‐1, and ICTP as markers of advanced periodontitis

Gürsoy, Ulvi Kahraman; Könönen, Eija; Pradhan-Palikhe, Pratikshya; Tervahartiala, Taina; Pussinen, Pirkko J.; Suominen-Taipale, Liisa; Sorsa, Timo

doi:10.1111/j.1600-051x.2010.01563.x

Cited by 180 publications

(257 citation statements)

References 38 publications

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“…11 Although in many earlier studies saliva has been used, being easily available and a noninvasive specimen to detect the various cytokines associated with periodontal diseases, in our study, we used plasma sample because markers, such as TNF-α and IL-6 are reported to be present in less amount in saliva. [12][13][14] In this study, the proportion of male population was higher in comparison to the female population and the male population showed greater duration of uncontrolled diabetes as well.…”

Section: Discussionmentioning

confidence: 82%

Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus

Bakshi¹,

Kaur

Singh

et al. 2018

The Journal of Contemporary Dental Practice

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Introduction: Both periodontitis and type II diabetes mellitus (T2DM) are common diseases with a multifactorial etiology and have influence of cytokines in their pathogenesis and thus may also influence each other. In recent times, more attention has been given to understanding the influences of these inflammatory cytokines which are a main part of oral chronic inflammation on systemic health of the individuals. Therefore, the aim of this study was to evaluate the plasma cytokine levels, specifically tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-4, in chronic periodontitis patients and T2DM patients, so as to investigate the influence of chronic periodontitis in systemic inflammation associated with diabetes mellitus. Materials and methods:The present study comprised a total sample size of 60 patients. A detailed history along with complete periodontal examination were done for each person. These patients were subdivided into four study groups with 15 subjects (n = 15) in each group: group I: healthy individuals, group II: chronic periodontitis, group III: diabetes mellitus without chronic periodontitis, and group IV: diabetes mellitus with chronic periodontitis. Venous blood was withdrawn for obtaining serum samples from the subjects. Hemoglobin A1c (HbA1c) levels were measured from the automated chromatography. Using enzyme-linked immunosorbent assay kit, TNF-α, IL-4, and IL-6 were measured.

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Section: Discussionmentioning

confidence: 82%

Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus

Bakshi¹,

Kaur

Singh

et al. 2018

The Journal of Contemporary Dental Practice

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“…Passoja A et al, [21] in their study found, MMP-8 concentrations to be significantly higher in smokers as compared to nonsmokers with relation to Probing pocket depth and clinical attachment. Similarly Gursoy UK, et al, [22] found in their study that smokers with periodontitis had a higher expression of MMP-8 with increase in the probing pocket depth as compared to Non-smokers with periodontitis. A significant correlation between increased MMP-8 levels and periodontal disease severity was suggested by Liu et al, [18] who reported increased local MMP-8 expression in the periodontal tissues of smokers compared to the nonsmokers.…”

Section: (Cpn) and Group Ii-b (Hn) Group I-a (Cps) And Group Ii-a (Hmentioning

confidence: 94%

Effect of Smoking on Periodontal Health

Visvanathan

Mahendra

Ambalavanan

et al. 2014

JCDR

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Aims and Objectives: The aim of the study was to assess and compare the effect of smoking on mRNA expression of MMP -8 and TIMP-1 in patients with untreated chronic periodontitis and in periodontally healthy subjects and to examine the correlation of MMP-8 and TIMP-1 levels with clinical parameters. Materials and Methods:Out of 60 subjects, 40 were selected subjects for the study, and were divided into Group I (periodontitis subject) and Group II (healthy subjects). Each group was further subdivided into subgroups I-A (chronic periodontitis smokers CPS), and I-B (chronic periodontitis non-smokers CPN), subgroup II-A (healthy smokers HS) and II B (healthy non-smokers HS). Both the groups underwent periodontal examination and clinical parameters were recorded. Tissue samples from both groups were subjected to the isolation of RNA which was then followed by qRT-PCR and the expression of the mRNA levels of MMP-8 and TIMP-1 were analyzed.

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“…1,2 The levels of MMPs have been studied extensively in gingival crevicular fluid (GCF) 3,4 and saliva 5,6 and have been shown to be elevated in patients with periodontitis compared to periodontally healthy subjects. Further, periodontal treatment resulted in decreases in GCF levels of MMPs.…”

Section: Introductionmentioning

confidence: 99%

Levels of gingival crevicular fluid matrix metalloproteinases in periodontally compromised teeth under orthodontic forces

Almeida

Capelli

Teles³

2015

The Angle Orthodontist

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Objective: To examine levels of matrix metalloproteinases (MMPs)-1, -2, -3, -7, -8, -12, and -13 in the gingival crevicular fluid (GCF) of periodontally compromised teeth at different time points during orthodontic movement. Materials and Methods: Ten controlled periodontitis subjects were submitted to orthodontic treatment. One dental arch was subjected to orthodontic movement, and teeth in the opposite arch were used as controls. GCF samples were collected from the lingual sites of two movement and two control incisors 1 week before orthodontic activation (27 d), immediately after orthodontic activation, and after 1 hour, 24 hours, and 7, 14, and 21 days. Multiplexed bead immunoassay was used to measure MMPs in GCF. Data were analyzed using Friedman and Wilcoxon statistical tests. Results: The only significant change found over time was in the levels of MMP-1 in the movement group (P , .05). When the two groups were compared after activation, the only statistically significant difference found was in levels of MMP-12 24 hours after activation (P , .05). Conclusions: Our findings suggested that the orthodontic movement of periodontally compromised teeth without active pockets did not result in significant changes in the GCF levels of MMPs.

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Salivary MMP‐8, TIMP‐1, and ICTP as markers of advanced periodontitis

Abstract: Salivary MMP-8, TIMP-1, ICTP, and especially their ratios and combinations are potential candidates in the detection of advanced periodontitis. Differentiating periodontitis and control subjects with salivary MMP-8 detection is dependent on the selected techniques.

Cited by 180 publications

References 38 publications

Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus

Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus

Effect of Smoking on Periodontal Health

Levels of gingival crevicular fluid matrix metalloproteinases in periodontally compromised teeth under orthodontic forces

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