Salvia sclarea L. Essential Oil Extract and Its Antioxidative Phytochemical Sclareol Inhibit Oxytocin-Induced Uterine Hypercontraction Dysmenorrhea Model by Inhibiting the Ca2+–MLCK–MLC20 Signaling Cascade: An Ex Vivo and In Vivo Study

Wong, Jennifer; Chiang, Yi Fen; Shih, Yin Hwa; Chiu, Chun‐Hui; Chen, Hsin Yuan; Shieh, Tzong‐Ming; Wang, Kai-Lee; Huang, Tsui-Chin; Hong, Yong Han; Hsia, Shih Min

doi:10.3390/antiox9100991

Cited by 35 publications

(14 citation statements)

References 43 publications

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“…Sclareol takes effect on Ca 2+ level and mediates oxytocin receptor (OXTR), myosin light chain kinase (MLCK), extracellular signal-regulated kinase, p-p38, cyclooxygenase-2 (COX-2), and phosphomyosin light chain 20 (p-MLC20) protein expression. Summarizing these results, sclareol is a promising alternative supplement in treatment of dysmenorrhea (Wong et al, 2020).…”

Section: Introductionmentioning

confidence: 89%

“…The methanol extracts of S. sclarea inhibited the growth of all tested bacterial strains, also this plant had a prominent antioxidant activity (Firuzi et al, 2013). Sclareol caused inhibition of prostaglandin (PG) F-2 alpha-, oxytocin-, acetylcholine-, carbachol-, KCl-, and Bay K 8644-induced uterine contraction and led to an analgesic effect in the writhing test (Wong et al, 2020). Sclareol takes effect on Ca 2+ level and mediates oxytocin receptor (OXTR), myosin light chain kinase (MLCK), extracellular signal-regulated kinase, p-p38, cyclooxygenase-2 (COX-2), and phosphomyosin light chain 20 (p-MLC20) protein expression.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Lieshchova

Bohomaz

Brygadyrenko

2021

Regul. Mech. Biosyst.

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Phytotherapy for the correction of excess body weight is widely used. However, a comprehensive study of herbal preparations on the organism of model animals has been carried out only for a few plant species. Supplementing the diet of rats with closely related sage species (Salvia officinalis L. and S. sclarea L.) against the background of high-fat hypercaloric diet triggered multidirectional changes in their metabolism. The addition of crushed dry shoots of S. officinalis to the diet of animals led to a sharp increase in their body weight (up to 130.8% of the initial one in 30 days of the experiment). The body weight of the rats treated with S. sclarea for 30 days increased only up to 103.8% of their initial weight and was lower than in the control group. Addition of S. officinalis caused an increase in daily weight gain up to 253.1% of the control group, and S. sclarea – its decrease to 27.8% of the daily weight gain in the control group. In the S. officinalis group, the relative weight of the brain, spleen, and thymus decreased, while in the S. sclarea group, the relative weight of the thymus decreased and that of the colon increased. Under the influence of S. officinalis, the concentration of urea, total bilirubin, and triglycerides in the blood plasma of male rats decreased and the concentration of total protein and the activity of alkaline phosphatase increased. While consuming S. sclarea shoots, there was an increase of alkaline phosphatase activity in the rats’ blood, but atherogenic index (23.1% of the level of the control group) sharply dropped due to an increase in the concentration of high-density lipoprotein cholesterol (286.9% of the control) and a decrease in the concentration of low-density lipoprotein cholesterol (67.7% of control). In rats feeding on S. sclarea shoots, we observed a decrease in the concentration of triglycerides in the blood (39.9% of the control), a decrease in the activity of gamma-glutamyl transferase (62.8%), and an increase in the Ca/P ratio (132.5% of the control group). No significant changes were observed in CBC and WBC differential of male rats when eating S. officinalis and S. sclarea shoots. According to the results of the open field test, the physical and orientational activity of male rats under the influence of S. officinalis significantly decreased by the end of the experiment. Emotional status of rats, on the contrary, decreased when they ate dry crushed shoots of S. sclarea in the composition of the food. Thus, excess body weight of rats in the conditions of hypercaloric diet led to more pronounced deviations from the norm while consuming dry crushed shoots of S. officinalis. The addition of S. sclarea dry crushed shoots to the animals’ diet normalized the body weight in comparison with the control group, reduced the negative manifestations of obesity at the biochemical and organismal levels. In this regard, the substances that contains S. sclarea should be carefully studied for anti-atherosclerotic activity, and tea supplemented with S. sclarea shoots can be recommended as a corrective supplement in the diet of overweight people.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Lieshchova

Bohomaz

Brygadyrenko

2021

Regul. Mech. Biosyst.

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“…Interestingly, SCL inhibited RANKL-induced osteoclastogenesis and osteoclast function in vitro (1–10 μm), which was associated with SCL-triggering the suppression of NF-κB and MAPK/ERK signaling pathways, and prevented ovariectomy -induced mouse model from bone loss in vivo ( Jin et al, 2019 ). SCL has been reported to improve dysmenorrhea and inflammation in dysmenorrhea models in vitro and in vivo via suppressing the Ca2+/MLCK/MLC20 pathway cascades ( Wong et al, 2020 ).…”

Section: Pharmacological Activities Of Sclareolmentioning

confidence: 99%

The bioactivities of sclareol: A mini review

Zhou

Xie²,

Tang³

et al. 2022

Front. Pharmacol.

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Sclareol, a diterpene alcohol isolated from the herbal and flavor plant clary sage (Salvia sclarea L.), is far-famed as the predominant ingredient in the refined oil of Salvia sclarea (L.). The empirical medicine of Salvia sclarea L. focused on various diseases, such as arthritis, oral inflammation, digestive system diseases, whereas the sclareol possessed more extensive and characteristic bioactivities, including anti-tumor, anti-inflammation and anti-pathogenic microbes, even anti-diabetes and hypertension. However, there is a deficiency of literature to integrate and illuminate the pharmacological attributes of sclareol based on well-documented investigations. Interestingly, sclareol has been recently considered as the potential candidate against COVID-19 and Parkinson’s disease. Accordingly, the bioactive attributes of sclareol in cancer, inflammation, even pharmacochemistry and delivery systems are reviewed for comprehensively dissecting its potential application in medicine.

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“…Several other studies, as summarized in Table 3 , have investigated some other natural products on other axes of Ca 2+ signaling, such as on type 1 collagen [ 178 ], calmodulin phosphor kinase II [ 176 ], L-type Ca 2+ -gated channel [ 179 , 180 ], and myosin light chain kinase [ 181 ]. There is a need for more focused studies on the management and improvement of bone health through the several Ca 2+ signaling axes.…”

Section: Cellular and Molecular Mechanisms Of Bone Health-promoting P...mentioning

confidence: 99%

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

Okagu

Ezeorba

Aguchem

et al. 2022

IJMS

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The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs’ adoption. This review discusses the pathological development of some BDs, the NP-targeted components, and the actions exerted on bone remodeling signaling pathways (e.g., Receptor Activator of Nuclear Factor κ B-ligand (RANKL)/monocyte/macrophage colony-stimulating factor (M-CSF)/osteoprotegerin (OPG), mitogen-activated protein kinase (MAPK)s/c-Jun N-terminal kinase (JNK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Kelch-like ECH-associated protein 1 (Keap-1)/nuclear factor erythroid 2–related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1), Bone Morphogenetic Protein 2 (BMP2)-Wnt/β-catenin, PhosphatidylInositol 3-Kinase (PI3K)/protein kinase B (Akt)/Glycogen Synthase Kinase 3 Beta (GSK3β), and other signaling pathways). Although majority of the studies on the osteoprotective properties of NPs against BDs were conducted ex vivo and mostly on animals, the use of NPs for treating human BDs and the prospects for future development remain promising.

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Salvia sclarea L. Essential Oil Extract and Its Antioxidative Phytochemical Sclareol Inhibit Oxytocin-Induced Uterine Hypercontraction Dysmenorrhea Model by Inhibiting the Ca2+–MLCK–MLC20 Signaling Cascade: An Ex Vivo and In Vivo Study

Cited by 35 publications

References 43 publications

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

The bioactivities of sclareol: A mini review

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

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