Saussurea lappa: An Important Medicinal Plant for Treatment Different Diseases: A review

Ali, Alaq Hameed; Alqaseer, Kawther; Fatlawi, Duaa; Shehab, Salma; Falah, Mansour Abdullah; Hassan, M. S.; Shnain, Wijdan; Radhi, Ohoud

doi:10.36321/kjns.vi20211.427

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…In addition, it is used as an antispasmodic in asthmatic patients and also in the treatment of cholera, gout, erysipelas, etc. [ 34 ]. The compounds isolated from A. costus have been found to be effective against a wide range of cancers, such as ovarian, pancreatic, prostatic, colon and bladder cancer, leukemia, etc.…”

Section: Introductionmentioning

confidence: 99%

HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells

et al. 2023

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Aucklandia costus Falc. (Synonym: Saussurea costus (Falc.) Lipsch.) is a perennial herb of the family Asteraceae. The dried rhizome is an essential herb in the traditional systems of medicine in India, China and Tibet. The important pharmacological activities reported for Aucklandia costus are anticancer, hepatoprotective, antiulcer, antimicrobial, antiparasitic, antioxidant, anti-inflammatory and anti-fatigue activities. The objective of this study was the isolation and quantification of four marker compounds in the crude extract and different fractions of A. costus and the evaluation of the anticancer activity of the crude extract and its different fractions. The four marker compounds isolated from A. costus include dehydrocostus lactone, costunolide, syringin and 5-hydroxymethyl-2-furaldehyde. These four compounds were used as standard compounds for quantification. The chromatographic data showed good resolution and excellent linearity (r2 ˃ 0.993). The validation parameters, such as inter- and intraday precision (RSD < 1.96%) and analyte recovery (97.52–110.20%; RSD < 2.00%),revealed the high sensitivity and reliability of the developed HPLC method. The compounds dehydrocostus lactone and costunolide were concentrated in the hexane fraction (222.08 and 65.07 µg/mg, respectively) and chloroform fraction (99.02 and 30.21 µg/mg, respectively), while the n-butanol fraction is a rich source of syringin (37.91 µg/mg) and 5-hydroxymethyl-2-furaldehyde (7.94 µg/mg). Further, the SRB assay was performed for the evaluation of anticancer activity using lung, colon, breast and prostate cancer cell lines. The hexane and chloroform fractions show excellent IC50 values of 3.37 ± 0.14 and 7.527 ± 0.18 µg/mL, respectively, against the prostate cancer cell line (PC-3).

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Section: Introductionmentioning

confidence: 99%

HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells

et al. 2023

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“…One of the largest angiosperm families, Asteraceae has around 23,600 species of plants, including trees, shrubs, and herbs in 1,620 genera. There are roughly 300 species in the Saussure genus [1]. Indian costus roots' chemical constituents have been studied since the 1950s.…”

Section: Introductionmentioning

confidence: 99%

Investigate Indian Costus Plasma Parameters using Q-Switched Laser Nd: YAG

Hussein

Abdullah

2023

IJP

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The Indian costus plasma properties are investigated including electron temperature (Te), "electron density (ne)", "plasma frequency (fp)", " Debye sphere length", and amount of Debye(Nd), using the spectrum of optical emission technique. There are several energies used, with ranging from 300 to 600 mJ. The Boltzmann Plot is used to calculate the temperature; where as Stark's Line Broadening is used to calculate the electron density. The Indian costus was spectroscopically examined in the air with the laser at 10 cm away from the target and the optical fiber at 0.5 cm away. The results were obtained for an electron temperature range of (1.8-2.2) electron volts (ev) and a wavelength range of (300-600) nm. The XRF analysis reveals that the Indian costus contains a variety of minerals, each with a different percentage, which explains why the optical emission spectrum has so many peaks. When the laser energy is (between 300 and 600 mJ) the "optical emission spectroscopy (OES) "has been used to analyze the plasma spectrum of the Indian costus in the air. The results shows that as the laser energy grew, the amount of Debye will be greater i-e (Nd) >>>1, which is one of the plasma properties.

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“…Helminthiasis, gout, spleen inflammation brought on by infection, parasite infection, or abscesses, menopause (abnormal absence of menstruation). In tradition, S. costus is used to treat headaches, loss of appetite, diarrhea, and abdominal pain [3,5]. Various profuse metabolites like sesquiterpenes, phytosterols, flavonoids, lignans, and terpenes were determined in the phytochemistry of S. costus [2].…”

Section: Introductionmentioning

confidence: 99%

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

Al-Zayadi,

Shanan,

Salihi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Saussurea costus (Sc) plant belongs to the Asteraceae family. It contains various bioactive compounds used traditionally in treating multiple diseases. This study intends to extract and evaluate the active ingredients of Sc roots (Scrs) and determine their antibacterial activities. S. costus roots were purchased from the herbal market and the chemical compositions, including protein, lipid, carbohydrates, moisture, and ash, were determined according to AOAC procedures 2016 with some modifications. HPLC and amino acids analyzer were used to determine the phenolic compounds and amino acid composition of S. costus roots extract (ScrsE). The antibacterial activities of S. costus roots extract were done according to the Kirby-Bauer disc diffusion method. The S. costus roots were revealed a fusiform (or) conical and tapering appearance, collapsing in the centre with longitudinal wrinkles revealing 11-19 cm and 1-2.5 cm for long and wide, respectively. The extraction yield was 9.52% and the weight of the concentrated crude extract was 10 g. According to Proximate analysis, the S. costus roots extract showed 3.88% and 20.12% moisture and ash contents, respectively. The compositions of carbohydrates, protein, and crude fat were 75.25%, 2.51%, and 1.85%, respectively. HPLC analysis showed that the S. costus roots Extract contained two phenolic acids and two flavonoids. Moreover, twelve amino acids were determined for the first time in the S. costus roots extract. Various antibacterial activities were seen with maximum inhibition zone for Streptococcus pyogenes & E.coli; and minimum for Bacillus subtilis & Pseudomonas aeruginosa. In conclusion, this study investigated various contents of S. costus roots extract including amino acids, carbohydrates, protein, and crude fat, in addition to its antibacterial activities. The authors recommend more future studies to investigate the therapeutic activities of S. costus roots extract.

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Saussurea lappa: An Important Medicinal Plant for Treatment Different Diseases: A review

Cited by 5 publications

References 9 publications

HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells

HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells

Investigate Indian Costus Plasma Parameters using Q-Switched Laser Nd: YAG

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

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