2016
DOI: 10.1016/j.lfs.2016.04.017
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Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression

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Cited by 59 publications
(40 citation statements)
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“…The effect of COX-2 inhibition on wound healing is controversial. In line with our finding COX-2 inhibition was reported to relieve inflammatory response in sponge implants model of wound healing and promotes the closure of excisional lesions [42,79]. However, Other studies, showed that COX inhibition does not affect wound healing [80,81] and other studies showed that COX-2 inhibition reduces the wound closure delay the healing [82,83].…”
Section: Discussionsupporting
confidence: 85%
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“…The effect of COX-2 inhibition on wound healing is controversial. In line with our finding COX-2 inhibition was reported to relieve inflammatory response in sponge implants model of wound healing and promotes the closure of excisional lesions [42,79]. However, Other studies, showed that COX inhibition does not affect wound healing [80,81] and other studies showed that COX-2 inhibition reduces the wound closure delay the healing [82,83].…”
Section: Discussionsupporting
confidence: 85%
“…Our ongoing work investigate the regulation of wound TGF Beta-1 by other inflammatory mediators mainly COX and iNOS. Recently, Roman-Souz et al [42] have shown inter-regulation between COX-2 and iNOS in a model of wound healing and we have shown interregulation of TGF Beta-1 and NOS in keloids [34] and in acute wounds (manuscript in preparation).…”
Section: Interrelation Between Inflammatory Mediators In Wound Healinmentioning
confidence: 61%
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“…It is known that hypoxia and also subsequent oxygenation at reperfusion provoke the formation of reactive oxygen species (ROS) that in turn contribute necrotic lesions in I/R‐induced pressure ulcers lesions . Selective inhibition of COX‐2 by celecoxib has been shown to improve wound healing of pressure ulcers through reducing expression level of iNOS . Olive oil‐induced reduction in oxidative damage and inflammation can accelerate the resolution of pressure ulcers lesion in mice .…”
Section: Discussionmentioning
confidence: 99%
“…© C I C E d i z i o n i I n t e r n a z i o n a l i 59 and 35% in the paratenon, but there was no effect on their numbers in the tendon core 9 . In pressure ulcers, celecoxib diminished the neutrophils at 3 days and macrophages at 3 and 7 days after ulceration 10 . In a full thickness skin wound healing model, celecoxib also reduced the number of neutrophils 48 hours after surgery 11 .…”
Section: Discussionmentioning
confidence: 92%