Selenium-engineered covalent organic frameworks for high-efficiency and long-acting cancer therapy

Abstract

A porphyrin containing covalent organic frameworks (COF) is synthesized as the substrate to decorate selenium nanoparticles (Se NPs) via in situ reduction, which could employ Se NPs mediated therapy (SeT)...

Therapeutic Benefits of Selenium in Hematological Malignancies

“…Similarly, Wan et al, synthesized a porphyrin-containing covalent organic framework (COF) as a substrate for accommodating Se NPs, thus preventing the aggregation of Se NPs and enhance the stability. The combination of Se NP-mediated therapy with photodynamic therapy (PDT) greatly achieved long-acting and effective anticancer effects [ 221 ]. So, the futuristic studies exploring Se-based therapy alone or in conjunction with other therapeutics for the effective treatment of cancers are highly encouraged.…”

Post-synthetic modifications in porous organic polymers for biomedical and related applications

“…8d) on the surface of nCOFs. 70 The authors further modified the Se NP decorated nCOFs by PEGylation to make them biocompatible. The Se NPs were stabilized with this strategy, protected from aggregation, and successfully delivered to the tumor site.…”

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…808 As nanoplatforms, COFs easily integrate multiple diagnostic and therapeutic strategies to achieve nanotheranostics. 179 To date, COFs have been validated in the laboratory stage for drug delivery, [809][810][811][812][813][814][815][816][817][818] phototherapy, [819][820][821][822][823][824][825] immunotherapy, 151,741,[826][827][828] and combination therapy applications. 817,[829][830][831][832] In particular, the antitumor application of metalated COFs has been a promising research topic in COF-based nanomedicine.…”