Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs

Abstract

Metal-bisphosphonates are self-sacrificial controlled delivery systems that achieve ultra-long release of anti-osteoporotic bisphosphonate drugs.

Bone Tissue Disorders: Healing Through Coordination Chemistry

“…Formulation of ag iven coordinationc ompound should consider that the same building blocks (organic linker and metal centers)can lead to the formation of severaldistinct structures, which sometimes hinders the preparation of phase-pure compounds. [18,19,21] In addition, it is important to ensuret hat the synthesis of pure materials is cost-effective, reproductible and environmentally friendly. [17] Here, one should consider the use of microwave-assisted synthesis as asimple and highly efficient process, with an uniform,f ast and focused heating of the reaction vessels, affordingp hase pure materials,i nh igh reaction yields, in short reaction times (a few minutes), using small amountsofsolvents.…”

“…[33][34][35][36][37][38] Amidst these, there are cases in which both the organic linkers and the metal ions have intrinsic therapeutic properties. [18,19,21,39] In other systems, only one of the building blocks has therapeutic value for bone tissue (e.g.,b isphosphonates as linkers which are modulators of bone remodeling, widely used in the clinical practicef or the treatment of bone tissue disorders such as osteoporosis and Paget's disease). [20,[40][41] The first report on ac oordination polymer with therapeutic potentialf or bone tissue dates back to 2013.…”

“…As bone-remodeling modulators, bisphosphonate drugs are used as organic linkersi nahandfulo fo ther reports.S uch is the case of as eries of materials, [19]…”

“…Another series of five coordination compounds containing alendronate and calcium, magnesium or zinc, was prepared: [21] Ca [18,19,42,43,46] Additional studies were carriedo ut on Caalendronate to determinet he effect of the particle size on the results of the cellular studies ( Figure 5). [21] This compound was prepared with particle sizes ranging from ca.…”

“…[18][19][20] In spite of this tailored composition,i th as been shownt hat, under physiological conditions, these elements can be released. [19,21] In this way,c oordination-based com-pounds may allow the delivery of multiple therapeutic agents to bone tissue, and are expected to accomplish ab etter therapeutic outcome because of the combined ands ynergistic action between all elements. [14][15][16][17]22] These are encouraging results to design innovatived elivery approaches.…”